Growth Hormone Receptor (GHR) Rat Recombinant Protein

GH receptor: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. Defects in GHR are a cause of Laron syndrome (LARS). A severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. Defects in GHR may be a cause of idiopathic short stature autosomal (ISSA). Short stature is defined by a subnormal rate of growth. Belongs to the type I cytokine receptor family. Type 1 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Cellular Component: cell soma; cell surface; cytoplasm; extracellular space; extrinsic to membrane; integral to membrane; integral to plasma membrane; mitochondrion; nucleus; plasma membrane; receptor complex

Molecular Function: growth factor binding; growth hormone receptor activity; peptide hormone binding; protein homodimerization activity; protein kinase binding; protein phosphatase binding; SH2 domain binding

Biological Process: 2-oxoglutarate metabolic process; activation of JAK protein; activation of MAPK activity; allantoin metabolic process; cellular response to hormone stimulus; cellular response to insulin stimulus; citrate metabolic process; creatine metabolic process; creatinine metabolic process; fatty acid metabolic process; hormone-mediated signaling; insulin-like growth factor receptor signaling pathway; isoleucine metabolic process; JAK-STAT cascade; multicellular organismal metabolic process; oxaloacetate metabolic process; positive regulation of cell differentiation; positive regulation of JAK-STAT cascade; positive regulation of multicellular organism growth; positive regulation of peptidyl-tyrosine phosphorylation; receptor internalization; regulation of multicellular organism growth; response to cycloheximide; response to cytokine stimulus; response to estradiol stimulus; response to food; response to glucocorticoid stimulus; response to hormone stimulus; response to morphine; response to peptide hormone stimulus; succinate metabolic process; taurine metabolic process; tyrosine phosphorylation of JAK2 protein; valine metabolic process