Human SPRED1 Recombinant Protein – Cat# MBS140666

Sprouty-Related EVH1 Domain Containing 1 (SPRED1) Human Recombinant Protein

Name: SPRED1 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS140666
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS140666

Introduction: Sprouty-Related EVH1 Domain Containing 1, also known as SPRED1, is a part of the Sprouty family of proteins and is phosphorylated by tyrosine kinase. SPRED1 inhibits growth-factor-mediated activation of MAP kinase. SPRED1 plays a role as a… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Sprouty-Related EVH1 Domain Containing 1 (SPRED1), Recombinant Protein

Full Product Name

Recombinant Human Sprouty-Related EVH1 Domain Containing 1

Product Gene Name

SPRED1 recombinant protein

Product Synonym Names

SPRED1 Human; Sprouty-Related EVH1 Domain Containing 1 Human Recombinant; Sprouty-Related EVH1 Domain Containing 1; SPRED1; Spred-1; hSpred1; NFLS

Sequence

MGSSHHH HHH SSGLVPRGSH MGSMSE ETAT SDNDNSYARV RAVVMTRDDS SGGWLPLGGS GLSSVTVFKV PHQEENGCAD FFIRGERLRD KMVVLECMLK KDLIYNKVTP TFHHWKIDDK KFGLTFQSPA DARAFDRGIR RAIEDISQGC PESKNEAEGA DDLQANEEDS SSSLVKDHLF QQETVVTSEP YRSSNIRPSP FEDLNARRVY MQSQANQITF GQPGLDIQSR SMEYVQRQIS KECGSLKSQN RVPLKSIRHV SFQDEDEIVR INPRDILIRR YADYRHPDMW KNDLERDDAD SSIQFSKPDS KKSDYLYSCG DETKLSSPKD SVVFKTQPSS LKIKKSKRRK EDGERSRCVY CQERFNHEEN VRGKCQDAPD PIKRCIYQVS CMLCAESMLY HCMSDSEGDF SDPCSCDTSD DKFCLRWLAL VALSFIVPCM CCYVPLRMCH RCGEACGCCG GKHKAAG.

Host

E Coli

Form/Format

The SPRED1 solution (0.5mg/1ml) contains 20mM Tris-HCl (pH 8.0) and 10% glycerol.
Sterile Filtered clear solution.

Purity/Purification

Greater than 80.0% as determined by SDS-PAGE.

Molecular Weight

50,477 Da

OMIM

609291

3D Structure

ModBase 3D Structure for Q7Z699

Product Categories/Family for SPRED1 recombinant protein

Recombinant & Natural Proteins

Other Notes

Small volumes of SPRED1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SPRED1 purchase

MBS140666 is a recombinant protein targeting SPRED1. Also known as Recombinant Human Sprouty-Related EVH1 Domain Containing 1. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for SPRED1. It may not necessarily be applicable to this product.

NCBI GI #

22749221

NCBI GeneID

161742

NCBI Accession #

NP_689807.1

UniProt Primary Accession #

Q7Z699

UniProt Secondary Accession #

Q05D53; Q8N256; B2RPJ8

UniProt Related Accession #

Q7Z699

GenBank Nucleotide #

NM_152594.2

NCBI Official Full Name

sprouty-related, EVH1 domain-containing protein 1

NCBI Official Synonym Full Names

sprouty related, EVH1 domain containing 1

NCBI Official Symbol

SPRED1

NCBI Official Synonym Symbols

NFLS; hSpred1; spred-1; PPP1R147

UniProt Protein Name

Sprouty-related, EVH1 domain-containing protein 1

Protein Family

UniProt Gene Name

SPRED1

UniProt Synonym Gene Names

Spred-1; hSpred1

UniProt Entry Name

SPRE1_HUMAN

NCBI Protein Information

sprouty-related, EVH1 domain-containing protein 1

UniProt Comments for SPRED1

SPRED1: Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow. Defects in SPRED1 are the cause of neurofibromatosis type 1-like syndrome (NFLS). It is a disorder characterized mainly by cafe au lait macules without neurofibromas or other tumor manifestations of neurofibromatosis type 1, axillary freckling, and macrocephaly. Additional clinical manifestations include Noonan-like facial dysmorphism, lipomas, learning disabilities and attention deficit-hyperactivity.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 15q14

Cellular Component: cytoplasm; cytosol; nucleoplasm; plasma membrane

Molecular Function: phosphatase binding; protein binding; protein kinase binding; protein serine/threonine kinase inhibitor activity; stem cell factor receptor binding

Biological Process: fibroblast growth factor receptor signaling pathway; inactivation of MAPK activity; MAPKKK cascade; positive regulation of DNA damage response, signal transduction by p53 class mediator

Disease: Legius Syndrome

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SPRED1 recombinant protein

Reference Product	PubMed Publications
KIT recombinant protein	>6 publications with SPRED1 and KIT
PTPN11 recombinant protein	>6 publications with SPRED1 and PTPN11
PIK3R2 recombinant protein	>3 publications with SPRED1 and PIK3R2
HRAS recombinant protein	>3 publications with SPRED1 and HRAS
TESK1 recombinant protein	>2 publications with SPRED1 and TESK1
UBC recombinant protein	>1 publications with SPRED1 and UBC

Pathways associated with SPRED1 recombinant protein

Products by Pathway	Pathway Diagram
ARMS-mediated Activation Pathway antibodies	ARMS-mediated Activation Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
DAP12 Interactions Pathway antibodies	DAP12 Interactions Pathway Diagram
DAP12 Signaling Pathway antibodies	DAP12 Signaling Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
Downstream Signal Transduction Pathway antibodies	Downstream Signal Transduction Pathway Diagram
Downstream Signaling Of Activated FGFR1 Pathway antibodies	Downstream Signaling Of Activated FGFR1 Pathway Diagram
Downstream Signaling Of Activated FGFR2 Pathway antibodies	Downstream Signaling Of Activated FGFR2 Pathway Diagram
Downstream Signaling Of Activated FGFR3 Pathway antibodies	Downstream Signaling Of Activated FGFR3 Pathway Diagram

Diseases associated with SPRED1 recombinant protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>29 publications with SPRED1 and Nervous System Diseases
Legius syndrome Antibodies	>27 publications with SPRED1 and Legius syndrome
Neurofibromatosis 1 Antibodies	>25 publications with SPRED1 and Neurofibromatosis 1
Cafe-au-Lait Spots Antibodies	>24 publications with SPRED1 and Cafe-au-Lait Spots
Cardiovascular Diseases Antibodies	>9 publications with SPRED1 and Cardiovascular Diseases
Heart Defects, Congenital Antibodies	>7 publications with SPRED1 and Heart Defects, Congenital
Disease Models, Animal Antibodies	>5 publications with SPRED1 and Disease Models, Animal
Abnormalities, Multiple Antibodies	>5 publications with SPRED1 and Abnormalities, Multiple
Brain Diseases Antibodies	>4 publications with SPRED1 and Brain Diseases
Inflammation Antibodies	>4 publications with SPRED1 and Inflammation

Organs/Tissues associated with SPRED1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>17 publications with SPRED1 and Blood
Vascular Antibodies	>13 publications with SPRED1 and Vascular
Heart Antibodies	>12 publications with SPRED1 and Heart
Brain Antibodies	>12 publications with SPRED1 and Brain
Lung Antibodies	>11 publications with SPRED1 and Lung
Embryonic Tissue Antibodies	>6 publications with SPRED1 and Embryonic Tissue
Skin Antibodies	>5 publications with SPRED1 and Skin
Liver Antibodies	>5 publications with SPRED1 and Liver
Muscle Antibodies	>4 publications with SPRED1 and Muscle
Prostate Antibodies	>4 publications with SPRED1 and Prostate