Non-Metastatic Cells 2 (NME2) Rat Recombinant Protein

NME2: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity. Belongs to the NDK family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.13.3; EC 2.7.4.6; Kinase, nucleoside diphosphate; Kinase, other; NDK family; Nuclear receptor co-regulator; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Other group

Cellular Component: cytoplasm; focal adhesion; intermediate filament; lamellipodium; mitochondrial membrane; mitochondrion; myelin sheath; nucleus; perinuclear region of cytoplasm; ruffle

Molecular Function: drug binding; enzyme binding; fatty acid binding; intermediate filament binding; nucleoside diphosphate kinase activity; protein serine/threonine kinase activity

Biological Process: CTP biosynthetic process; GTP biosynthetic process; integrin-mediated signaling pathway; negative regulation of apoptosis; negative regulation of myeloid leukocyte differentiation; nucleoside diphosphate phosphorylation; nucleoside triphosphate biosynthetic process; positive regulation of cAMP biosynthetic process; positive regulation of epithelial cell proliferation; positive regulation of keratinocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid autophosphorylation; protein oligomerization; regulation of apoptosis; regulation of epidermis development; UTP biosynthetic process