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Pyrophosphatase-2 (PPA2) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS140673

Introduction: PPA2 shares great imagination with members of the inorganic pyrophosphatase (PPase) family. PPA2 is localized to the mitochondrion and owns the signature sequence necessary for the catalytic activity of PPase. PPases catalyze the hydrolysis of… More details

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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Pyrophosphatase-2 (PPA2), Recombinant Protein
Full Product Name
Recombinant Human Pyrophosphatase-2
Product Gene Name
PPA2 recombinant protein
Product Synonym Names
PPA2 Human; Pyrophosphatase-2 Human Recombinant; PPA2; Pyrophosphatase-2; Inorganic pyrophosphatase 2; mitochondrial; PPase 2; Pyrophosphatase SID6-306; Pyrophosphate phospho-hydrolase 2; HSPC124; Pyrophosphatase (inorganic) 2; SID6-306; Inorganic pyrophosphatase 2; mitochondrial isoform 1
Sequence
MGSSHHH HHH SSGLVPRGSH MGSALY HTEE RGQPCSQNYR LFFKNVTGHY ISPFHDIPLK VNSKEENGIP MKKARNDEYE NLFNMIVEIP RWTNAKMEIA TKEPMNPIKQ YVKDGKLRYV ANIFPYKGYI WNYGTLPQTW EDPHEKDKST NCFGDNDPID VCEIGSKILS CGEVIHVKIL GILALIDEGE TDWKLIAINA NDPEASKFHD IDDVKKFKPG YLEATLNWFR LYKVPDGKPE NQFAFNGEFK NKAFALEVIK STHQCWKALL MKKCNGGAIN CTNVQISDSP FRCTQEEARS LVESVSSSPN KESNEEEQVW HFLGK.
Host
E Coli
Form/Format
PPA2 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol, 1mM DTT.
Sterile Filtered colorless solution.
Purity/Purification
Greater than 95.0% as determined by SDS-PAGE.
Molecular Weight
25,992 Da
OMIM
609988
3D Structure
ModBase 3D Structure for Q9H2U2

Product Categories/Family for PPA2 recombinant protein

Enzymes

Other Notes

Small volumes of PPA2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PPA2 purchase

MBS140673 is a recombinant protein targeting PPA2. Also known as Recombinant Human Pyrophosphatase-2. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PPA2. It may not necessarily be applicable to this product.

NCBI GI #
77812678
NCBI GeneID
27068
NCBI Accession #
NP_008834.3
UniProt Primary Accession #
Q9H2U2
UniProt Secondary Accession #
Q4W5E9; Q6PG51; Q8TBW0; Q96E55; Q9H0T0; Q9NX37; Q9P033; Q9ULX0; B4DLP7; F8WDN9; I6L9B6
UniProt Related Accession #
Q9H2U2
GenBank Nucleotide #
NM_006903.4
NCBI Official Full Name
inorganic pyrophosphatase 2, mitochondrial isoform 2
NCBI Official Synonym Full Names
pyrophosphatase (inorganic) 2
NCBI Official Symbol
PPA2
NCBI Official Synonym Symbols
HSPC124; SID6-306
UniProt Protein Name
Inorganic pyrophosphatase 2, mitochondrial
UniProt Synonym Protein Names
Pyrophosphatase SID6-306; Pyrophosphate phospho-hydrolase 2; PPase 2
Protein Family
Major serine/threonine-protein phosphatase
UniProt Gene Name
PPA2
UniProt Synonym Gene Names
PPase 2
UniProt Entry Name
IPYR2_HUMAN
NCBI Protein Information
inorganic pyrophosphatase 2, mitochondrial

UniProt Comments for PPA2

PPA2: is localized to the mitochondrion, is highly similar to members of the inorganic pyrophosphatase (PPase) family, and contains the signature sequence essential for the catalytic activity of PPase. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Protein type: EC 3.6.1.1; Energy Metabolism - oxidative phosphorylation; Hydrolase; Mitochondrial

Chromosomal Location of Human Ortholog: 4q25

Cellular Component: mitochondrial matrix

Molecular Function: inorganic diphosphatase activity

Biological Process: tRNA aminoacylation for protein translation

Disease: Sudden Cardiac Failure, Alcohol-induced; Sudden Cardiac Failure, Infantile
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PPA2 recombinant protein

 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Mitochondrial TRNA Aminoacylation Pathway antibodies  Mitochondrial TRNA Aminoacylation Pathway Diagram
 Oxidative Phosphorylation Pathway antibodies  Oxidative Phosphorylation Pathway Diagram
 Oxidative Phosphorylation Pathway antibodies  Oxidative Phosphorylation Pathway Diagram
 TRNA Aminoacylation Pathway antibodies  TRNA Aminoacylation Pathway Diagram

Diseases associated with PPA2 recombinant protein

 Disease Name  Pubmed Publications
 Genital Diseases, Male Antibodies  >2 publications with PPA2 and Genital Diseases, Male
 Prostatic Diseases Antibodies  >2 publications with PPA2 and Prostatic Diseases
 Nervous System Diseases Antibodies  >1 publications with PPA2 and Nervous System Diseases
 Heart Diseases Antibodies  >1 publications with PPA2 and Heart Diseases
 Neoplasm Metastasis Antibodies  >1 publications with PPA2 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >1 publications with PPA2 and Breast Neoplasms
 Hyperplasia Antibodies  >1 publications with PPA2 and Hyperplasia

Organs/Tissues associated with PPA2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >3 publications with PPA2 and Heart
 Brain Antibodies  >3 publications with PPA2 and Brain
 Bone Antibodies  >2 publications with PPA2 and Bone
 Prostate Antibodies  >2 publications with PPA2 and Prostate
 Muscle Antibodies  >2 publications with PPA2 and Muscle
 Bone Marrow Antibodies  >2 publications with PPA2 and Bone Marrow
 Vascular Antibodies  >2 publications with PPA2 and Vascular
 Lymph Node Antibodies  >2 publications with PPA2 and Lymph Node
 Kidney Antibodies  >2 publications with PPA2 and Kidney
 Blood Antibodies  >1 publications with PPA2 and Blood
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