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Vacuolar-Sorting Protein SNF8 (SNF8) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1406737

MBS1406737 is a recombinant protein targeting SNF8. Also known as Recombinant Human Vacuolar-sorting protein SNF8 (SNF8). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$940 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Vacuolar-sorting protein SNF8 (SNF8), Recombinant Protein
Full Product Name
Recombinant Human Vacuolar-sorting protein SNF8 (SNF8)
Product Gene Name
SNF8 recombinant protein
Product Synonym Gene Name
SNF8
Sequence
MHRRGVGAGA IAKKKLAEAK YKERGTVLAE DQLAQMSKQL DMFKTNLEEF ASKHKQEIRK NPEFRVQFQD MCATIGVDPL ASGKGFWSEM LGVGDFYYEL GVQIIEVCLA LKHRNGGLIT LEELHQQVLK GRGKFAQDVS QDDLIRAIKK LKALGTGFGI IPVGGTYLIQ SVPAELNMDH TVVLQLAEKN GYVTVSEIKA SLKWETERAR QVLEHLLKEG LAWLDLQAPG EAHYWLPALF TDLYSQEITA EEAREALP
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
28,736 Da
Sequence Positions
1-258, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
610904
3D Structure
ModBase 3D Structure for Q96H20
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of SNF8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SNF8. It may not necessarily be applicable to this product.

NCBI GI #
953953835
NCBI GeneID
11267
NCBI Accession #
NP_001304121.1
UniProt Primary Accession #
Q96H20
UniProt Secondary Accession #
Q8IXY3; Q9UN50
UniProt Related Accession #
Q96H20
GenBank Nucleotide #
NM_001317192.1
NCBI Official Full Name
vacuolar-sorting protein SNF8 isoform 2
NCBI Official Synonym Full Names
SNF8, ESCRT-II complex subunit
NCBI Official Symbol
SNF8
NCBI Official Synonym Symbols
Dot3; EAP30; VPS22
UniProt Protein Name
Vacuolar-sorting protein SNF8
UniProt Synonym Protein Names
ELL-associated protein of 30 kDa; ESCRT-II complex subunit VPS22; hVps22
Protein Family
Vacuolar-sorting protein
UniProt Gene Name
SNF8
UniProt Synonym Gene Names
EAP30; hVps22
NCBI Protein Information
vacuolar-sorting protein SNF8

NCBI Summary for SNF8

The protein encoded by this gene is a component of the endosomal sorting complex required for transport II (ESCRT-II), which regulates the movement of ubiquitinylated transmembrane proteins to the lysosome for degradation. This complex also interacts with the RNA polymerase II elongation factor (ELL) to overcome the repressive effects of ELL on RNA polymerase II activity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
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UniProt Comments for SNF8

Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
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Research Articles on SNF8

1. data describe an unappreciated role for EAP30 in IRF3-dependent innate antiviral response in the nucleus.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SNF8 recombinant protein

 Reference Product  PubMed Publications
 VPS36 recombinant protein  >9 publications with SNF8 and VPS36
 VPS25 recombinant protein  >6 publications with SNF8 and VPS25
 TSG101 recombinant protein  >3 publications with SNF8 and TSG101
 ELL recombinant protein  >3 publications with SNF8 and ELL
 CHMP3 recombinant protein  >2 publications with SNF8 and CHMP3

Pathways associated with SNF8 recombinant protein

 Products by Pathway  Pathway Diagram
 ESCRT-II Complex Pathway antibodies  ESCRT-II Complex Pathway Diagram
 ESCRT-II Complex Pathway antibodies  ESCRT-II Complex Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endosomal Sorting Complex Required For Transport (ESCRT) Pathway antibodies  Endosomal Sorting Complex Required For Transport (ESCRT) Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Vesicle-mediated Transport Pathway antibodies  Vesicle-mediated Transport Pathway Diagram

Diseases associated with SNF8 recombinant protein

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >2 publications with SNF8 and Kidney Diseases
 Immune System Diseases Antibodies  >1 publications with SNF8 and Immune System Diseases
 Neoplasm Metastasis Antibodies  >1 publications with SNF8 and Neoplasm Metastasis
 Heart Diseases Antibodies  >1 publications with SNF8 and Heart Diseases
 Hypertension Antibodies  >1 publications with SNF8 and Hypertension
 Hypertrophy Antibodies  >1 publications with SNF8 and Hypertrophy
 Hemorrhage Antibodies  >1 publications with SNF8 and Hemorrhage

Organs/Tissues associated with SNF8 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >2 publications with SNF8 and Vascular
 Kidney Antibodies  >2 publications with SNF8 and Kidney
 Nerve Antibodies  >1 publications with SNF8 and Nerve
 Muscle Antibodies  >1 publications with SNF8 and Muscle
 Liver Antibodies  >1 publications with SNF8 and Liver
 Intestine Antibodies  >1 publications with SNF8 and Intestine
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