Peroxiredoxin-2 (PRDX2) Rat Recombinant Protein

PRDX2: a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). May have a proliferative effect and play a role in cancer development or progression. Three splice-variant isoforms have been identified.

Protein type: EC 1.11.1.15; Oxidoreductase

Cellular Component: cytosol; mitochondrion; myelin sheath

Molecular Function: antioxidant activity; thioredoxin peroxidase activity

Biological Process: activation of MAPK activity; homeostasis of number of cells; hydrogen peroxide catabolic process; hydrogen peroxide metabolic process; inhibition of NF-kappaB transcription factor; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of neuron apoptosis; negative regulation of T cell differentiation; positive regulation of blood coagulation; regulation of apoptosis; regulation of hydrogen peroxide metabolic process; removal of superoxide radicals; respiratory burst during acute inflammatory response; response to lipopolysaccharide; response to oxidative stress; T cell proliferation; thymus development