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UL16 Binding Protein 3 (ULBP3) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS140770

ULBP3 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain (Asp30-Gly217) containing 198 amino acids including a 10 aa His tag at N-terminus. The total calculated molecular mass is 23.25kDa. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
UL16 Binding Protein 3 (ULBP3), Recombinant Protein
Full Product Name
Recombinant Human UL16 Binding Protein 3
Product Gene Name
ULBP3 recombinant protein
Product Synonym Names
ULBP3 Human; UL16 Binding Protein 3 Human Recombinant; UL16 Binding Protein 3; Retinoic Acid Early Transcript 1N; ALCAN-Gamma; NKG2DL3; N2DL-3; RAET1N; UL16-Binding Protein 3; NKG2D Ligand 3; N2DL3; ULBP3
Sequence
MKHHHHHHAS DAHSLWYNFT IIHLPRHGQQ WCEVQSQVDQ KNFLSYDCGS DKVLSMGHLE EQLYATDAWG KQLEMLREVG QRLRLELADT ELEDFTPSGP LTLQVRMSCE CEADGYIRGS WQFSFDGRKF LLFDSNNRKW TVVHAGARRM KEKWEKDSGL TTFFKMVSMR DCKSWLRDFL MHRKKRLEPT APPTMAPG.
Host
E Coli
Form/Format
ULBP3 was filtered (0.4 um) and lyophilized in 20mM Tris buffer, 50mM NaCl and 0.1% v/v amisoft CS-22, pH 7.5.
Filtered White lyophilized (freeze-dried) powder.
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE
Preparation and Storage
Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
OMIM
605699
3D Structure
ModBase 3D Structure for Q9BZM4
Solubility
It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. ULBP3 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

Product Categories/Family for ULBP3 recombinant protein

Recombinant & Natural Proteins

Other Notes

Small volumes of ULBP3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ULBP3 purchase

MBS140770 is a recombinant protein targeting ULBP3. Also known as Recombinant Human UL16 Binding Protein 3. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for ULBP3. It may not necessarily be applicable to this product.

NCBI GI #
13375656
NCBI GeneID
79465
NCBI Accession #
NP_078794.1
UniProt Primary Accession #
Q9BZM4
UniProt Secondary Accession #
Q5VY82; Q8IZX5; Q8TE75
UniProt Related Accession #
Q9BZM4
GenBank Nucleotide #
NM_024518.2
NCBI Official Full Name
NKG2D ligand 3
NCBI Official Synonym Full Names
UL16 binding protein 3
NCBI Official Symbol
ULBP3
NCBI Official Synonym Symbols
N2DL-3; RAET1N; NKG2DL3
UniProt Protein Name
NKG2D ligand 3
UniProt Synonym Protein Names
ALCAN-gamma; Retinoic acid early transcript 1N
Protein Family
NKG2D ligand
UniProt Gene Name
ULBP3
UniProt Synonym Gene Names
N2DL3; RAET1N; N2DL-3; NKG2DL3
UniProt Entry Name
N2DL3_HUMAN
NCBI Protein Information
NKG2D ligand 3

UniProt Comments for ULBP3

ULBP3: Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. Has lower affinity for NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does ULBP2 or ULBP1. Belongs to the MHC class I family.

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 6q25

Cellular Component: anchored to plasma membrane; plasma membrane

Molecular Function: antigen binding; natural killer cell lectin-like receptor binding

Biological Process: antigen processing and presentation; natural killer cell activation; natural killer cell mediated cytotoxicity; regulation of immune response
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with ULBP3 recombinant protein

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram

Diseases associated with ULBP3 recombinant protein

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >8 publications with ULBP3 and Necrosis
 Lymphatic Diseases Antibodies  >5 publications with ULBP3 and Lymphatic Diseases
 Alopecia Areata Antibodies  >5 publications with ULBP3 and Alopecia Areata
 Nasopharyngeal carcinoma Antibodies  >3 publications with ULBP3 and Nasopharyngeal carcinoma
 Stomach Neoplasms Antibodies  >3 publications with ULBP3 and Stomach Neoplasms
 Adenocarcinoma Antibodies  >3 publications with ULBP3 and Adenocarcinoma
 Inflammation Antibodies  >2 publications with ULBP3 and Inflammation
 Cardiovascular Diseases Antibodies  >2 publications with ULBP3 and Cardiovascular Diseases
 Multiple Myeloma Antibodies  >2 publications with ULBP3 and Multiple Myeloma
 Uterine Cervical Neoplasms Antibodies  >2 publications with ULBP3 and Uterine Cervical Neoplasms

Organs/Tissues associated with ULBP3 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >8 publications with ULBP3 and Bone
 Lung Antibodies  >5 publications with ULBP3 and Lung
 Skin Antibodies  >4 publications with ULBP3 and Skin
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