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Nuclear Factor Erythroid 2-Like 2 (NFE2L2) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS140801

Introduction: Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is bZIP transcription factors which heterodimerize with Maf proteins to bind Mare sequences. In addition, the NRF proteins bind the antioxidant response element (ARE) and are associated with the… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Nuclear Factor Erythroid 2-Like 2 (NFE2L2), Recombinant Protein
Full Product Name
Recombinant Human Nuclear Factor Erythroid 2-Like 2
Product Gene Name
NFE2L2 recombinant protein
Product Synonym Names
NFE2L2 Human; Nuclear Factor Erythroid 2-Like 2 Human Recombinant; NFE2L2; Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor; erythroid derived 2; like 2; NRF2
Sequence
MGSSHHH HHH SSGLVPRGSH MMDLEL PPPG LPSQQDMDLI DILWRQDIDL GVSREVFDFS QRRKEYELEK QKKLEKERQE QLQKEQEKAF FAQLQLDEET GEFLPIQPAQ HIQSETSGSA NYSQVAHIPK SDALYFDDCM QLLAQTFPFV DDNEVSSATF QSLVPDIPGH IESPVFIATN QAQSPETSVA QVAPVDLDGM QQDIEQVWEE LLSIPELQCL NIENDKLVET TMVPSPEAKL TEVDNYHFYS SIPSMEKEVG NCSPHFLNAF EDSFSSILST EDPNQLTVNS LNSDATVNTD FGDEFYSAFI AEPSISNSMP SPATLSHSLS ELLNGPIDVS DLSLCKAFNQ NHPESTAEFN DSDSGISLNT SPSVASPEHS VESSSYGDTL LGLSDSEVEE LDSAPGSVKQ NGPKTPVHSS GDMVQPLSPS QGQSTHVHDA QCENTPEKEL PVSPGHRKTP FTKDKHSSRL EAHLTRDELR AKALHIPFPV EKIINLPVVD FNEMMSKEQF NEAQLALIRD IRRRGKNKVA AQNCRKRKLE NIVELEQDLD HLKDEKEKLL KEKGENDKSL HLLKKQLSTL YLEVFSMLRD EDGKPYSPSE YSLQQTRDGN VFLVPKSKKP DVKKN
Host
E Coli
Form/Format
NFE2L2 protein solution (0.25mg/ml) in Phosphate buffer saline (pH 7.4) containing 10% glycerol.
Sterile Filtered clear solution.
Purity/Purification
Greater than 85.0% as determined by SDS-PAGE.
Molecular Weight
65,356 Da
OMIM
600492
3D Structure
ModBase 3D Structure for Q16236

Product Categories/Family for NFE2L2 recombinant protein

Recombinant & Natural Proteins

Other Notes

Small volumes of NFE2L2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NFE2L2 purchase

MBS140801 is a recombinant protein targeting NFE2L2. Also known as Recombinant Human Nuclear Factor Erythroid 2-Like 2. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for NFE2L2. It may not necessarily be applicable to this product.

NCBI GI #
224028257
NCBI GeneID
4780
NCBI Accession #
NP_001138884.1
UniProt Primary Accession #
Q16236
UniProt Secondary Accession #
Q53RW6; Q59HH2; Q96F71; B2RBU2; B4E338; E9PGJ7
UniProt Related Accession #
Q16236
GenBank Nucleotide #
NM_001145412.3
NCBI Official Full Name
nuclear factor erythroid 2-related factor 2 isoform 2
NCBI Official Synonym Full Names
nuclear factor, erythroid 2 like 2
NCBI Official Symbol
NFE2L2
NCBI Official Synonym Symbols
NRF2; HEBP1
UniProt Protein Name
Nuclear factor erythroid 2-related factor 2
UniProt Synonym Protein Names
HEBP1; Nuclear factor, erythroid derived 2, like 2
Protein Family
Nuclear factor erythroid 2-related factor
UniProt Gene Name
NFE2L2
UniProt Synonym Gene Names
NRF2; NF-E2-related factor 2; NFE2-related factor 2
UniProt Entry Name
NF2L2_HUMAN
NCBI Protein Information
nuclear factor erythroid 2-related factor 2

UniProt Comments for NFE2L2

NRF2: a transcription factor that regulates basal expression and antioxidant induction of a transcription factor for NAD(P)H:quinone oxidoreductase-1 (NQO1) and other detoxifying genes. Targeted for proteasomal degradation by INrf2. Oxidative stress causes its phosphorylation and release from INrf2.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 2q31

Cellular Component: centrosome; cytoplasm; cytosol; nucleus; plasma membrane

Molecular Function: DNA binding; protein binding; protein domain specific binding; transcription factor activity

Biological Process: positive regulation of transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; protein ubiquitination; transcription from RNA polymerase II promoter; unfolded protein response
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NFE2L2 recombinant protein

 Reference Product  PubMed Publications
 HMOX1 recombinant protein  >1539 publications with NFE2L2 and HMOX1
 KEAP1 recombinant protein  >1068 publications with NFE2L2 and KEAP1
 JUN recombinant protein  >553 publications with NFE2L2 and JUN
 CUL3 recombinant protein  >86 publications with NFE2L2 and CUL3
 MAFK recombinant protein  >33 publications with NFE2L2 and MAFK
 MAFG recombinant protein  >28 publications with NFE2L2 and MAFG
 GSTA2 recombinant protein  >25 publications with NFE2L2 and GSTA2
 MAFF recombinant protein  >4 publications with NFE2L2 and MAFF
 UBC recombinant protein  >4 publications with NFE2L2 and UBC
 EIF2AK3 recombinant protein  >2 publications with NFE2L2 and EIF2AK3

Pathways associated with NFE2L2 recombinant protein

 Products by Pathway  Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 Keap1-Nrf2 Pathway antibodies  Keap1-Nrf2 Pathway Diagram
 Oxidative Stress Pathway antibodies  Oxidative Stress Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Selenium Metabolism And Selenoproteins Pathway antibodies  Selenium Metabolism And Selenoproteins Pathway Diagram

Diseases associated with NFE2L2 recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >777 publications with NFE2L2 and Inflammation
 Nervous System Diseases Antibodies  >439 publications with NFE2L2 and Nervous System Diseases
 Necrosis Antibodies  >356 publications with NFE2L2 and Necrosis
 Liver Diseases Antibodies  >340 publications with NFE2L2 and Liver Diseases
 Kidney Diseases Antibodies  >157 publications with NFE2L2 and Kidney Diseases
 Drug-Induced Liver Injury Antibodies  >155 publications with NFE2L2 and Drug-Induced Liver Injury
 Fibrosis Antibodies  >138 publications with NFE2L2 and Fibrosis
 Gastrointestinal Diseases Antibodies  >124 publications with NFE2L2 and Gastrointestinal Diseases
 Heart Diseases Antibodies  >123 publications with NFE2L2 and Heart Diseases
 Liver Neoplasms Antibodies  >123 publications with NFE2L2 and Liver Neoplasms

Organs/Tissues associated with NFE2L2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >747 publications with NFE2L2 and Liver
 Blood Antibodies  >611 publications with NFE2L2 and Blood
 Lung Antibodies  >499 publications with NFE2L2 and Lung
 Brain Antibodies  >460 publications with NFE2L2 and Brain
 Vascular Antibodies  >321 publications with NFE2L2 and Vascular
 Kidney Antibodies  >273 publications with NFE2L2 and Kidney
 Muscle Antibodies  >268 publications with NFE2L2 and Muscle
 Heart Antibodies  >255 publications with NFE2L2 and Heart
 Skin Antibodies  >153 publications with NFE2L2 and Skin
 Intestine Antibodies  >109 publications with NFE2L2 and Intestine
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