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C-Type Lectin Domain Family 5 (CLEC5A) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS140831

Introduction: C-type lectin superfamily member 5 (CLECSF5) and myeloid DAP12-associating lectin 1 (MDL1), aka CLE5CA is a C-type lectin. CLE5CA is a member of a significant myeloid lineage activating pathway. The CLE5CA protein acts as a positive regulator of… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
C-Type Lectin Domain Family 5 (CLEC5A), Recombinant Protein
Full Product Name
Recombinant Human C-Type Lectin Domain Family 5, Member A
Product Gene Name
CLEC5A recombinant protein
Product Synonym Names
CLEC5A Human; C-Type Lectin Domain Family 5, Member A Human Recombinant; C-type lectin domain family 5 member A; CLECSF5; MDL-1; MDL1; C-type lectin superfamily member 5; Myeloid DAP12-associating lectin 1
Sequence
MGSSHHH HHH SSGLVPRGSH MGSPQI FNKS NDGFTTTRSY GTVSQIFGSS SPSPNGFITT RSYGTVCPKD WEFYQARCFF LSTSESSWNE SRDFCKGKGS TLAIVNTPEK LKFLQDITDA EKYFIGLIYH REEKRWRWIN NSVFNGNVTN QNQNFNCATI GLTKTFDAAS CDISYRRICE KNAK
Host
E Coli
Form/Format
CLEC5A protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer, (pH8.0) and 10% glycerol.
Sterile Filtered clear solution.
Purity/Purification
Greater than 80.0% as determined by SDS-PAGE.
Molecular Weight
21,393 Da
OMIM
604987
3D Structure
ModBase 3D Structure for Q9NY25

Product Categories/Family for CLEC5A recombinant protein

Recombinant & Natural Proteins

Other Notes

Small volumes of CLEC5A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CLEC5A purchase

MBS140831 is a recombinant protein targeting CLEC5A. Also known as Recombinant Human C-Type Lectin Domain Family 5, Member A. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CLEC5A. It may not necessarily be applicable to this product.

NCBI GI #
10281669
NCBI GeneID
23601
NCBI Accession #
NP_037384.1
UniProt Primary Accession #
Q9NY25
UniProt Secondary Accession #
Q52M11; Q9UKQ0
UniProt Related Accession #
Q9NY25
GenBank Nucleotide #
NM_013252.2
NCBI Official Full Name
C-type lectin domain family 5 member A isoform 1
NCBI Official Synonym Full Names
C-type lectin domain family 5 member A
NCBI Official Symbol
CLEC5A
NCBI Official Synonym Symbols
MDL1; MDL-1; CLECSF5
UniProt Protein Name
C-type lectin domain family 5 member A
UniProt Synonym Protein Names
C-type lectin superfamily member 5; Myeloid DAP12-associating lectin 1; MDL-1
Protein Family
C-type lectin domain family
UniProt Gene Name
CLEC5A
UniProt Synonym Gene Names
CLECSF5; MDL1; MDL-1
UniProt Entry Name
CLC5A_HUMAN
NCBI Protein Information
C-type lectin domain family 5 member A

UniProt Comments for CLEC5A

CLEC5A: Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation. Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q33

Cellular Component: cell surface; integral to plasma membrane; plasma membrane

Molecular Function: viral receptor activity

Biological Process: cellular defense response; innate immune response; negative regulation of apoptosis; osteoblast development; signal transduction
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CLEC5A recombinant protein

 Products by Pathway  Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram

Diseases associated with CLEC5A recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >12 publications with CLEC5A and Inflammation
 Necrosis Antibodies  >5 publications with CLEC5A and Necrosis
 Disease Models, Animal Antibodies  >4 publications with CLEC5A and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >3 publications with CLEC5A and Cardiovascular Diseases
 Severe Dengue Antibodies  >3 publications with CLEC5A and Severe Dengue
 Respiratory Tract Diseases Antibodies  >1 publications with CLEC5A and Respiratory Tract Diseases
 Pneumonia Antibodies  >1 publications with CLEC5A and Pneumonia
 Respiratory Tract Infections Antibodies  >1 publications with CLEC5A and Respiratory Tract Infections
 Lung Diseases Antibodies  >1 publications with CLEC5A and Lung Diseases

Organs/Tissues associated with CLEC5A recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >18 publications with CLEC5A and Blood
 Bone Marrow Antibodies  >4 publications with CLEC5A and Bone Marrow
 Brain Antibodies  >3 publications with CLEC5A and Brain
 Eye Antibodies  >1 publications with CLEC5A and Eye
 Connective Tissue Antibodies  >1 publications with CLEC5A and Connective Tissue
 Lung Antibodies  >1 publications with CLEC5A and Lung
 Kidney Antibodies  >1 publications with CLEC5A and Kidney
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