Profilin-1 (PFN1) Recombinant Protein

profilin 1: a ubiquitous actin monomer-binding protein belonging to the profilin family. At high concentrations, profilin 1 prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Deletion of this gene is associated with Miller-Dieker syndrome.

Protein type: Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: cell cortex; cell-cell adherens junction; cytoplasm; cytosol; focal adhesion; membrane; nucleus

Molecular Function: actin binding; actin monomer binding; adenyl-nucleotide exchange factor activity; phosphatidylinositol-4,5-bisphosphate binding; protein binding

Biological Process: negative regulation of actin filament bundle formation; negative regulation of actin filament polymerization; negative regulation of stress fiber formation; positive regulation of actin filament bundle formation; positive regulation of actin filament polymerization; positive regulation of ATPase activity; protein stabilization; Wnt receptor signaling pathway, planar cell polarity pathway

Disease: Amyotrophic Lateral Sclerosis 18