Human FKBP5 Recombinant Protein – Cat# MBS140848

FK506 Binding Protein 5 (FKBP5) Human Recombinant Protein

Name: FKBP5 Recombinant Protein; FK506 Binding Protein 5; Human; MyBioSource
Brand: MyBioSource
SKU: MBS140848
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS140848

Introduction: FK506 Binding Protein 5 (FKBP5) belongs to the immunophilin protein family, which has a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP5 is a cis-trans prolyl isomerase, which binds to the… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FK506 Binding Protein 5 (FKBP5), Recombinant Protein

Full Product Name

Recombinant Human FK506 Binding Protein 5

Product Gene Name

FKBP5 recombinant protein

Product Synonym Names

FK506 Binding Protein 5, 54 KDa Progesterone Receptor-Associated Immunophilin, 51 KDa FK506-Binding Protein, Androgen-Regulated Protein 6, HSP90-Binding Immunophilin, FK506-Binding Protein 5, PPIase FKBP5, 51 KDa FKBP, FF1 Antigen, EC 5.2.1.8, Rotamase, FKBP-51, FKBP51, FKBP54, AIG6, P54, Peptidylprolyl Cis-Trans Isomerase, T-Cell FK506-Binding Protein, PPIASE, Ptg-10, FKBP-5, FKBP5.

Sequence

MKHHHHHHAS MTTDEGAKNN EESPTATVAE QGEDITSKKD RGVLKIVKRV GNGEETPMIG DKVYVHYKGK LSNGKKFDSS HDRNEPFVFS LGKGQVIKAW DIGVATMKKG EICHLLCKPE YAYGSAGSLP KIPSNATLFF EIELLDFKGE DLFEDGGIIR RTKRKGEGYS NPNEGATVEI HLEGRCGGRM FDCRDVAFTV GEGEDHDIPI GIDKALEKMQ REEQCILYLG PRYGFGEAGK PKFGIEPNAE LIYEVTLKSF EKAKESWEMD TKEKLEQAAI VKEKGTVYFK GGKYMQAVIQ YGKIVSWLEM EYGLSEKESK ASESFLLAAF LNLAMCYLKL REYTKAVECC DKALGLDSAN EKGLYRRGEA QLLMNEFESA KGDFEKVLEV NPQNKAARLQ ISMCQKKAKE HNERDRRIYA NMFKKFAEQD AKEEANKAMG KKTSEGVTNE KGTDSQAMEE EKPEGHV.

Host

E coli

Form/Format

FKBP5 was filtered (0.4um) and lyophilized in 20mM Tris buffer and 50mM NaCl, pH 7.5.!!Solubility||

Purity/Purification

Greater than 90.0% as determined by SDS-PAGE.

Preparation and Storage

Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

Molecular Weight

30,032 Da

OMIM

602623

Physical Appearance

Filtered White lyophilized (freeze-dried) powder.

Solubility

It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Filter sterilize your culture media/working solutions containing this non-sterile FKBP5 before using in cell culture.

Product Categories/Family for FKBP5 recombinant protein

Enzymes

Other Notes

Small volumes of FKBP5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FKBP5 purchase

MBS140848 is a recombinant protein targeting FKBP5. Also known as Recombinant Human FK506 Binding Protein 5. Host: E coli.

Additional Details

NCBI/Uniprot data below describe general gene information for FKBP5. It may not necessarily be applicable to this product.

NCBI GI #

83404904

NCBI GeneID

2289

NCBI Accession #

AAI11051.1

UniProt Secondary Accession #

Q59EB8; Q5TGM6; F5H7R1

UniProt Related Accession #

Q13451

NCBI Official Full Name

FK506 binding protein 5

NCBI Official Synonym Full Names

FK506 binding protein 5

NCBI Official Symbol

FKBP5

NCBI Official Synonym Symbols

P54; AIG6; FKBP51; FKBP54; PPIase; Ptg-10

UniProt Protein Name

Peptidyl-prolyl cis-trans isomerase FKBP5

UniProt Synonym Protein Names

51 kDa FK506-binding protein; 51 kDa FKBP; FKBP-51; 54 kDa progesterone receptor-associated immunophilin; Androgen-regulated protein 6; FF1 antigen; FK506-binding protein 5; FKBP-5; FKBP54; p54; HSP90-binding immunophilin; Rotamase

Protein Family

FK506-binding protein

UniProt Gene Name

FKBP5

UniProt Synonym Gene Names

AIG6; FKBP51; PPIase FKBP5; 51 kDa FKBP; FKBP-51; FKBP-5; p54

UniProt Entry Name

FKBP5_HUMAN

NCBI Protein Information

peptidyl-prolyl cis-trans isomerase FKBP5

UniProt Comments for FKBP5

FKBP5: Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP. Part of a heteromultimeric cytoplasmic complex with HSP90, HSP70 and steroid receptors. Dissociates from the complex when NR3C1 binds glucocorticoid. By androgen. Widely expressed, enriched in testis compared to other tissues. Inhibited by FK506 but not cyclosporin.

Protein type: Chaperone; EC 5.2.1.8; Isomerase

Chromosomal Location of Human Ortholog: 6p21.31

Cellular Component: endoplasmic reticulum membrane; membrane; nucleoplasm

Molecular Function: heat shock protein binding; peptidyl-prolyl cis-trans isomerase activity; protein binding

Biological Process: protein folding

Disease: Major Depressive Disorder

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FKBP5 recombinant protein

Reference Product	PubMed Publications
FKBP4 recombinant protein	>20 publications with FKBP5 and FKBP4
MTOR recombinant protein	>4 publications with FKBP5 and MTOR
AKT1 recombinant protein	>1 publications with FKBP5 and AKT1
HSP90AA1 recombinant protein	>1 publications with FKBP5 and HSP90AA1

Pathways associated with FKBP5 recombinant protein

Products by Pathway	Pathway Diagram
Estrogen Signaling Pathway antibodies	Estrogen Signaling Pathway Diagram
Estrogen Signaling Pathway antibodies	Estrogen Signaling Pathway Diagram
Glucocorticoid Receptor Regulatory Network Pathway antibodies	Glucocorticoid Receptor Regulatory Network Pathway Diagram
Prostate Cancer Pathway antibodies	Prostate Cancer Pathway Diagram
TNF-alpha/NF-kB Signaling Pathway antibodies	TNF-alpha/NF-kB Signaling Pathway Diagram

Diseases associated with FKBP5 recombinant protein

Disease Name	Pubmed Publications
Depressive Disorder, Major Antibodies	>41 publications with FKBP5 and Depressive Disorder, Major
Inflammation Antibodies	>15 publications with FKBP5 and Inflammation
Disease Models, Animal Antibodies	>10 publications with FKBP5 and Disease Models, Animal
Neoplasms, Experimental Antibodies	>8 publications with FKBP5 and Neoplasms, Experimental
Necrosis Antibodies	>7 publications with FKBP5 and Necrosis
Memory Disorders Antibodies	>6 publications with FKBP5 and Memory Disorders
Learning Disorders Antibodies	>5 publications with FKBP5 and Learning Disorders
Hypertension Antibodies	>5 publications with FKBP5 and Hypertension
Hyperplasia Antibodies	>4 publications with FKBP5 and Hyperplasia
Cognition Disorders Antibodies	>4 publications with FKBP5 and Cognition Disorders

Organs/Tissues associated with FKBP5 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>116 publications with FKBP5 and Brain
Blood Antibodies	>76 publications with FKBP5 and Blood
Prostate Antibodies	>19 publications with FKBP5 and Prostate
Kidney Antibodies	>10 publications with FKBP5 and Kidney
Heart Antibodies	>10 publications with FKBP5 and Heart
Muscle Antibodies	>7 publications with FKBP5 and Muscle
Vascular Antibodies	>7 publications with FKBP5 and Vascular
Intestine Antibodies	>6 publications with FKBP5 and Intestine
Lung Antibodies	>4 publications with FKBP5 and Lung
Liver Antibodies	>4 publications with FKBP5 and Liver