Human HADHB Recombinant Protein – Cat# MBS140855

2-Enoyl-Coenzyme A (HADHB) Human Recombinant Protein

Name: HADHB Recombinant Protein; 2-Enoyl-Coenzyme A; Human; MyBioSource
Brand: MyBioSource
SKU: MBS140855
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS140855

Introduction: 2-Enoyl-Coenzyme A (CoA) Hydratase, Beta (HADHB) is the beta subunit of the mitochondrial trifunctional protein, that catalyzes the last 3 phases of mitochondrial beta-oxidation of long chain fatty acids. HADHB binds RNA and reduces the… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

2-Enoyl-Coenzyme A (HADHB), Recombinant Protein

Full Product Name

Recombinant Human 2-Enoyl-Coenzyme A (CoA) Hydratase, Beta

Product Gene Name

HADHB recombinant protein

Product Synonym Names

HADHB Human; 2-Enoyl-Coenzyme A (CoA) Hydratase, Beta Human Recombinant; Hydroxyacyl-CoA Dehydrogenase/3-Ketoacyl-CoA Thiolase/Enoyl-CoA Hydratase (Trifunctional Protein) Beta Subunit; Hydroxyacyl-Coenzyme A Dehydrogenase/3-Ketoacyl-Coenzyme A Thiolase/Enoyl-Coenzyme A Hydratase (Trifunctional Protein) Beta Subunit; TP-BETA; 3-Ketoacyl-Coenzyme A (CoA) Thiolase Of Mitochondrial Trifunctional Protein Beta Subunit; 2-Enoyl-Coenzyme A (CoA) Hydratase Beta Subunit; Trifunctional Enzyme Subunit Beta Mitochondrial; Mitochondrial Trifunctional Protein; Acetyl-CoA Acyltransferase; Beta-Ketothiolase; Beta Subunit; EC 2.3.1.16; EC 2.3.1; MSTP029; ECHB; MTPB

Sequence

MGSSHHH HHH SSGLVPRGSH MGSAAP AVQT KTKKTLAKPN IRNVVVVDGV RTPFLLSGTS YKDLMPHDLA RAALTGLLHR TSVPKEVVDY IIFGTVIQEV KTSNVAREAA LGAGFSDKTP AHTVTMACIS ANQAMTTGVG LIASGQCDVI VAGGVELMSD VPIRHSRKMR KLMLDLNKAK SMGQRLSLIS KFRFNFLAPE LPAVSEFSTS ETMGHSADRL AAAFAVSRLE QDEYALRSHS LAKKAQDEGL LSDVVPFKVP GKDTVTKDNG IRPSSLEQMA KLKPAFIKPY GTVTAANSSF LTDGASAMLI MAEEKALAMG YKPKAYLRDF MYVSQDPKDQ LLLGPTYATP KVLEKAGLTM NDIDAFEFHE AFSGQILANF KAMDSDWFAE NYMGRKTKVG LPPLEKFNNW GGSLSLGHPF GATGCRLVMA AANRLRKEGG QYGLVAACAA GGQGHAMIVE AYPK.

Host

E Coli

Form/Format

HADHB protein solution (0.5mg/ml) containing 20mM phosphate (pH8.0) and 10% glycerol.
Sterile Filtered clear solution.

Purity/Purification

Greater than 90.0% as determined by SDS-PAGE.

Molecular Weight

48,880 Da

OMIM

143450

3D Structure

ModBase 3D Structure for P55084

Product Categories/Family for HADHB recombinant protein

Enzymes

Other Notes

Small volumes of HADHB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HADHB purchase

MBS140855 is a recombinant protein targeting HADHB. Also known as Recombinant Human 2-Enoyl-Coenzyme A (CoA) Hydratase, Beta. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for HADHB. It may not necessarily be applicable to this product.

NCBI GI #

4504327

NCBI GeneID

3032

NCBI Accession #

NP_000174.1

UniProt Primary Accession #

P55084

UniProt Secondary Accession #

O14969; Q53TA6; Q96C77; Q9H3F5; Q9T2V8; B2RB16; B4E2W0

UniProt Related Accession #

P55084

GenBank Nucleotide #

NM_000183.2

NCBI Official Full Name

trifunctional enzyme subunit beta, mitochondrial isoform 1

NCBI Official Synonym Full Names

hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit

NCBI Official Symbol

HADHB

NCBI Official Synonym Symbols

ECHB; MTPB; MSTP029; TP-BETA

UniProt Protein Name

Trifunctional enzyme subunit beta, mitochondrial

UniProt Synonym Protein Names

TP-betaIncluding the following 1 domains:3-ketoacyl-CoA thiolase (EC:2.3.1.16)Alternative name(s):Acetyl-CoA acyltransferase; Beta-ketothiolase

Protein Family

Trifunctional enzyme

UniProt Gene Name

HADHB

UniProt Entry Name

ECHB_HUMAN

NCBI Protein Information

trifunctional enzyme subunit beta, mitochondrial

UniProt Comments for HADHB

HADHB: Defects in HADHB are a cause of trifunctional protein deficiency (TFP deficiency). The clinical manifestations are very variable and include hypoglycemia, cardiomyopathy and sudden death. Phenotypes with mainly hepatic and neuromyopathic involvement can also be distinguished. Biochemically, TFP deficiency is defined by the loss of all three enzyme activities of the TFP complex. Belongs to the thiolase family.

Protein type: Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 2.3.1.16; Lipid Metabolism - fatty acid; Lipid Metabolism - fatty acid elongation in mitochondria; Transferase

Chromosomal Location of Human Ortholog: 2p23

Cellular Component: endoplasmic reticulum; mitochondrial envelope; mitochondrial inner membrane; mitochondrial outer membrane

Molecular Function: 3-hydroxyacyl-CoA dehydrogenase activity; enoyl-CoA hydratase activity; protein binding

Biological Process: fatty acid beta-oxidation

Disease: Trifunctional Protein Deficiency

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with HADHB recombinant protein

Products by Pathway	Pathway Diagram
Acyl Chain Remodeling Of CL Pathway antibodies	Acyl Chain Remodeling Of CL Pathway Diagram
Beta Oxidation Of Decanoyl-CoA To Octanoyl-CoA-CoA Pathway antibodies	Beta Oxidation Of Decanoyl-CoA To Octanoyl-CoA-CoA Pathway Diagram
Beta Oxidation Of Hexanoyl-CoA To Butanoyl-CoA Pathway antibodies	Beta Oxidation Of Hexanoyl-CoA To Butanoyl-CoA Pathway Diagram
Beta Oxidation Of Lauroyl-CoA To Decanoyl-CoA-CoA Pathway antibodies	Beta Oxidation Of Lauroyl-CoA To Decanoyl-CoA-CoA Pathway Diagram
Beta Oxidation Of Myristoyl-CoA To Lauroyl-CoA Pathway antibodies	Beta Oxidation Of Myristoyl-CoA To Lauroyl-CoA Pathway Diagram
Beta Oxidation Of Octanoyl-CoA To Hexanoyl-CoA Pathway antibodies	Beta Oxidation Of Octanoyl-CoA To Hexanoyl-CoA Pathway Diagram
Beta Oxidation Of Palmitoyl-CoA To Myristoyl-CoA Pathway antibodies	Beta Oxidation Of Palmitoyl-CoA To Myristoyl-CoA Pathway Diagram
Fatty Acid Beta Oxidation Pathway antibodies	Fatty Acid Beta Oxidation Pathway Diagram
Fatty Acid Biosynthesis, Elongation, Mitochondria Pathway antibodies	Fatty Acid Biosynthesis, Elongation, Mitochondria Pathway Diagram
Fatty Acid Biosynthesis, Elongation, Mitochondria Pathway antibodies	Fatty Acid Biosynthesis, Elongation, Mitochondria Pathway Diagram

Diseases associated with HADHB recombinant protein

Disease Name	Pubmed Publications
Fatty Liver Antibodies	>11 publications with HADHB and Fatty Liver
Liver Diseases Antibodies	>6 publications with HADHB and Liver Diseases
Lipid Metabolism Disorders Antibodies	>6 publications with HADHB and Lipid Metabolism Disorders
Inflammation Antibodies	>3 publications with HADHB and Inflammation
Cardiovascular Diseases Antibodies	>3 publications with HADHB and Cardiovascular Diseases
Insulin Resistance Antibodies	>3 publications with HADHB and Insulin Resistance
Weight Gain Antibodies	>3 publications with HADHB and Weight Gain
Liver Failure, Acute Antibodies	>3 publications with HADHB and Liver Failure, Acute
Fibrosis Antibodies	>2 publications with HADHB and Fibrosis
Necrosis Antibodies	>2 publications with HADHB and Necrosis

Organs/Tissues associated with HADHB recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>15 publications with HADHB and Liver
Muscle Antibodies	>7 publications with HADHB and Muscle
Heart Antibodies	>7 publications with HADHB and Heart
Blood Antibodies	>6 publications with HADHB and Blood
Adipose Tissue Antibodies	>4 publications with HADHB and Adipose Tissue
Connective Tissue Antibodies	>3 publications with HADHB and Connective Tissue
Skin Antibodies	>2 publications with HADHB and Skin
Lung Antibodies	>2 publications with HADHB and Lung
Kidney Antibodies	>2 publications with HADHB and Kidney
Nerve Antibodies	>2 publications with HADHB and Nerve