Tissue Transglutaminase (TGM2) Mouse Recombinant Protein

TGM2: an enzyme of the transglutaminase family that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. . Is the autoantigen in coeliac disease and plays a role in apoptosis, cellular differentiation and matrix stabilisation. Three alternatively spliced isoforms have been described.

Protein type: EC 2.3.2.13; Transferase

Cellular Component: cytoplasm; cytosol; extracellular matrix; focal adhesion; intrinsic to plasma membrane; membrane; mitochondrion; plasma membrane; proteinaceous extracellular matrix

Molecular Function: GTP binding; protein domain specific binding; protein-glutamine gamma-glutamyltransferase activity; transaminase activity

Biological Process: apoptotic cell clearance; blood vessel remodeling; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); elevation of mitochondrial calcium ion concentration; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine; peptide cross-linking; positive regulation of apoptosis; positive regulation of cell adhesion; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of inflammatory response; positive regulation of smooth muscle cell proliferation; protein homooligomerization; reduction of endoplasmic reticulum calcium ion concentration