BCL2-Like 1 (BCL2) Mouse Recombinant Protein

Bcl-xL: an antiapoptotic member of the Bcl-2 family. Located at the outer mitochondrial membrane and regulates outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are potent inducers of cell apoptosis. Two alternatively spliced isoforms have been reported.

Protein type: Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial

Cellular Component: centrosome; cytoplasm; cytosol; intracellular; mitochondrial envelope; mitochondrial membrane; mitochondrial outer membrane; mitochondrion

Molecular Function: BH domain binding; BH3 domain binding; caspase inhibitor activity; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; transcription factor binding

Biological Process: cell proliferation; cellular process regulating host cell cycle in response to virus; cytokinesis; DNA damage response, signal transduction resulting in induction of apoptosis; fertilization; germ cell development; growth; in utero embryonic development; male gonad development; mitotic cell cycle checkpoint; negative regulation of apoptosis; negative regulation of neuron apoptosis; neuron apoptosis; ovarian follicle development; positive regulation of apoptosis; positive regulation of cell proliferation; regulation of apoptosis; regulation of mitochondrial membrane permeability; regulation of mitochondrial membrane potential; release of cytochrome c from mitochondria; response to cycloheximide; response to cytokine stimulus; response to radiation; response to virus; spermatogenesis; suppression by virus of host apoptosis