E3 Ubiquitin-Protein Ligase NRDP1 (RNF41) Human Recombinant Protein

This gene encodes an E3 ubiquitin ligase. The encoded protein plays a role in type 1 cytokine receptor signaling by controlling the balance between JAK2-associated cytokine receptor degradation and ectodomain shedding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]

RNF41: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 and Negatively regulates MYD88-dependent production of proinflammatory cytokines but can promote TRIF-dependent production of type I interferon. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL- 3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages. Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state.

Protein type: Ubiquitin ligase; EC 6.3.2.-; Ligase; Ubiquitin conjugating system; EC 6.3.2.19

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: cytosol

Molecular Function: interleukin-3 receptor binding; protein binding; protein tag; acid-amino acid ligase activity; erythropoietin receptor binding; zinc ion binding; Ral GTPase binding; ubiquitin-protein ligase activity

Biological Process: proteasomal protein catabolic process; negative regulation of cell proliferation; regulation of myeloid cell differentiation; protein autoubiquitination; protein polyubiquitination; regulation of lymphocyte differentiation; regulation of MAPKKK cascade; autophagy; positive regulation of transcription factor activity; regulation of protein kinase B signaling cascade; negative regulation of cell migration