FK506 Binding Protein 1a (FKBP1A) Mouse Recombinant Protein

FKBP12: an immunophilin and peptidyl-prolyl cis-trans isomerase that binds to the immunosuppressant drugs FK506 (a.k.a. tacrolimus or Fujimycin) and rapamycin (a.k.a. Sirolimus). The FKBP12/rapamycin complex binds NFAT transcription factors and inhibits the induction of T cell genes including IL-2, IL-3, IL-4, TNF-alpha and GM-CSF. FK506 is used in treating patients after organ transplant and those suffering from autoimmune disorders. The immunosuppressant activity of FKBP12 is not apparently related to its prolyl isomerase activity. The FKBP12/rapamycin complex inhibits the mammalian target of rapamycin (mTOR) pathway by directly binding the mTOR Complex1 (mTORC1). mTORC1 contains Raptor, mLST8, and PRAS40, and interacts with DEPTOR, which inhibits its activity. mTOR, a S/T protein kinase, is a central regulator of cellular growth and metabolism. Its inhibition enhances the dependence on aerobic glycolysis in leukemic cells.

Protein type: EC 5.2.1.8; Isomerase

Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; membrane; nerve terminal; sarcoplasmic reticulum membrane; Z disc

Molecular Function: activin binding; drug binding; enzyme binding; FK506 binding; Hsp70 protein binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; protein homodimerization activity; signal transducer activity; SMAD binding; transforming growth factor beta receptor binding

Biological Process: cytokine and chemokine mediated signaling pathway; fibril organization and biogenesis; heart morphogenesis; muscle contraction; negative regulation of protein amino acid phosphorylation; negative regulation of protein phosphatase type 2B activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of protein binding; positive regulation of protein ubiquitination; protein peptidyl-prolyl isomerization; regulation of activin receptor signaling pathway; regulation of immune response; regulation of protein localization; release of sequestered calcium ion into cytosol; response to caffeine; SMAD protein complex assembly; T cell proliferation; ventricular cardiac muscle morphogenesis