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Epithelial Cell Adhesion Molecule (EPCAM) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS140938

Introduction: EPCAM is a carcinoma-associated antigen and belongs to a family which includes at least 2 type I membrane proteins. The EPCAM protein has a role in embryonic stem cells proliferation and differentiation. EPCAM is used as a target for… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Epithelial Cell Adhesion Molecule (EPCAM), Recombinant Protein
Full Product Name
Recombinant Human Epithelial Cell Adhesion Molecule sf9
Product Gene Name
EPCAM recombinant protein
Product Synonym Names
EPCAM Human, sf9; Epithelial Cell Adhesion Molecule Human, Sf9; Epithelial Cell Adhesion Molecule; Tumor-Associated Calcium Signal Transducer 1; Major Gastrointestinal Tumor-Associated Protein GA733-2; Adenocarcinoma-Associated Antigen; Cell Surface Glycoprotein Trop-1; Epithelial Glycoprotein 314; TACSTD1; EGP314; MIC18; TROP1; M4S1; KSA; Membrane Component; Chromosome 4; Surface Marker (35kD Glycoprotein); Antigen Identified By Monoclonal Antibody AUA1; Human Epithelial Glycoprotein-2; Epithelial Cell Surface Antigen; Epithelial Glycoprotein; KS 1/4 Antigen; CD326 Antigen; GA733-2; HEGP314; HNPCC8; Ep-CAM; DIAR5; EGP-2; EGP40; KS1/4; MK-1; M1S2; ESA; EGP; EPCAM
Sequence
QEECVCENYK LAVNCFVNNN RQCQCTSVGA QNTVICSKLA AKCLVMKAEM NGSKLGRRAK PEGALQNNDG LYDPDCDESG LFKAKQCNGT STCWCVNTAG VRRTDKDTEI TCSERVRTYW IIIELKHKAR EKPYDSKSLR TALQKEITTR YQLDPKFITS ILYENNVITI DLVQNSSQKT QNDVDIADVA YYFEKDVKGE SLFHSKKMDL TVNGEQLDLD PGQTLIYYVD EKAPEFSMQG LKHHHHH H
Host
Sf9 Baculovirus Cells
Form/Format
EPCAM protein solution (1mg/ml) contains Phosphate buffered saline (pH7.4) and 10% glycerol.
Sterile filtered colorless solution.
Purity/Purification
Greater than 95.0% as determined by SDS-PAGE.
Molecular Weight
34,932 Da
OMIM
185535
3D Structure
ModBase 3D Structure for P16422

Product Categories/Family for EPCAM recombinant protein

Recombinant & Natural Proteins

Other Notes

Small volumes of EPCAM recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EPCAM purchase

MBS140938 is a recombinant protein targeting EPCAM. Also known as Recombinant Human Epithelial Cell Adhesion Molecule sf9. Host: Sf9 Baculovirus Cells.

Additional Details

NCBI/Uniprot data below describe general gene information for EPCAM. It may not necessarily be applicable to this product.

NCBI GI #
218505670
NCBI GeneID
4072
NCBI Accession #
NP_002345.2
UniProt Primary Accession #
P16422
UniProt Secondary Accession #
P18180; Q6FG26; Q6FG49; Q96C47; Q9UCD0
UniProt Related Accession #
P16422
GenBank Nucleotide #
NM_002354.2
NCBI Official Full Name
epithelial cell adhesion molecule
NCBI Official Synonym Full Names
epithelial cell adhesion molecule
NCBI Official Symbol
EPCAM
NCBI Official Synonym Symbols
ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1
UniProt Protein Name
Epithelial cell adhesion molecule
UniProt Synonym Protein Names
Adenocarcinoma-associated antigen; Cell surface glycoprotein Trop-1; Epithelial cell surface antigen; Epithelial glycoprotein; EGP; Epithelial glycoprotein 314; EGP314; hEGP314; KS 1/4 antigen; KSA; Major gastrointestinal tumor-associated protein GA733-2; Tumor-associated calcium signal transducer 1; CD_antigen: CD326
Protein Family
Epithelial cell adhesion molecule
UniProt Gene Name
EPCAM
UniProt Synonym Gene Names
GA733-2; M1S2; M4S1; MIC18; TACSTD1; TROP1; Ep-CAM; EGP; EGP314; hEGP314
UniProt Entry Name
EPCAM_HUMAN
NCBI Protein Information
epithelial cell adhesion molecule

UniProt Comments for EPCAM

EPCAM: a single-pass type I membrane protein of the EPCAM family. May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinomas including pancreatic carcinoma. May be a marker of cancer stem cells.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: apical plasma membrane; basolateral plasma membrane; integral to plasma membrane; lateral plasma membrane; plasma membrane; tight junction

Molecular Function: protein binding; protein complex binding

Biological Process: positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; stem cell differentiation

Disease: Colorectal Cancer, Hereditary Nonpolyposis, Type 8; Diarrhea 5, With Tufting Enteropathy, Congenital
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with EPCAM recombinant protein

 Reference Product  PubMed Publications
 MYC recombinant protein  >64 publications with EPCAM and MYC
 PROM1 recombinant protein  >58 publications with EPCAM and PROM1
 CDH1 recombinant protein  >43 publications with EPCAM and CDH1
 PTPRC recombinant protein  >26 publications with EPCAM and PTPRC
 TP53 recombinant protein  >22 publications with EPCAM and TP53
 CLDN7 recombinant protein  >20 publications with EPCAM and CLDN7
 TSPAN8 recombinant protein  >8 publications with EPCAM and TSPAN8
 CCND1 recombinant protein  >7 publications with EPCAM and CCND1
 NFKB1 recombinant protein  >2 publications with EPCAM and NFKB1
 GPNMB recombinant protein  >1 publications with EPCAM and GPNMB

Diseases associated with EPCAM recombinant protein

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >705 publications with EPCAM and Carcinoma
 Neoplasm Metastasis Antibodies  >434 publications with EPCAM and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >308 publications with EPCAM and Adenocarcinoma
 Breast Neoplasms Antibodies  >251 publications with EPCAM and Breast Neoplasms
 Liver Diseases Antibodies  >213 publications with EPCAM and Liver Diseases
 Liver Neoplasms Antibodies  >203 publications with EPCAM and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >182 publications with EPCAM and Carcinoma, Hepatocellular
 Lung Neoplasms Antibodies  >138 publications with EPCAM and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >133 publications with EPCAM and Neoplasms, Experimental
 Ovarian Neoplasms Antibodies  >105 publications with EPCAM and Ovarian Neoplasms

Organs/Tissues associated with EPCAM recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >565 publications with EPCAM and Blood
 Liver Antibodies  >350 publications with EPCAM and Liver
 Lung Antibodies  >215 publications with EPCAM and Lung
 Prostate Antibodies  >120 publications with EPCAM and Prostate
 Lymph Node Antibodies  >85 publications with EPCAM and Lymph Node
 Vascular Antibodies  >79 publications with EPCAM and Vascular
 Ascites Antibodies  >65 publications with EPCAM and Ascites
 Stomach Antibodies  >62 publications with EPCAM and Stomach
 Intestine Antibodies  >56 publications with EPCAM and Intestine
 Kidney Antibodies  >47 publications with EPCAM and Kidney
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