Human TPO Recombinant Protein – Cat# MBS140947

Thrombopoietin (TPO) Human Recombinant Protein

Name: TPO Recombinant Protein; Thrombopoietin; Human; MyBioSource
Brand: MyBioSource
SKU: MBS140947
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS140947

TPO produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 340 amino acids (22-353aa.) and having a molecular mass of 36.5kDa. (Molecular size on SDS-PAGE will appear at approximately 40-57KDa).TPO is expressed with an 8… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Thrombopoietin (TPO), Recombinant Protein

Full Product Name

Recombinant Human Thrombopoietin, His Tag

Product Gene Name

TPO recombinant protein

Product Synonym Names

TPO Human, His; ThrombopoietinHuman Recombinant, His Tag; MPL Ligand; THCYT1; MPLLG; TPO; ML; Thrombopoietin Nirs Variant 1; MKCSF; Thrombopoietin; Myeloproliferative Leukemia Virus Oncogene Ligand; Megakaryocyte Growth and Development Factor; Megakaryocyte Colony-Stimulating Factor; C-Mpl Ligand; MGDF; Megakaryocyte Stimulating Factor; Prepro-Thrombopoietin

Sequence

SPAPPACDLR VLSKLLRDSH VLHSRLSQCP EVHPLPTPVL LPAVDFSLGE WKTQMEETKA QDILGAVTLL LEGVMAARGQ LGPTCLSSLL GQLSGQVRLL LGALQSLLGT QLPPQGRTTA HKDPNAIFLS FQHLLRGKVR FLMLVGGSTL CVRRAPPTTA VPSRTSLVLT LNELPNRTSG LLETNFTASA RTTGSGLLKW QQGFRAKIPG LLNQTSRSLD QIPGYLNRIH ELLNGTRGLF PGPSRRTLGA PDISSGTSDT GSLPPNLQPG YSPSPTHPPT GQYTLFPLPP TLPTPVVQLH PLLPDPSAPT PTPTSPLLNT SYTHSQNLSQ EGLEHHH HHH.

Host

Sf9 Insect Cells

Form/Format

TPO protein solution (0.25mg/ml) contains phosphate buffered saline (pH7.4) and 10% glycerol.
Sterile Filtered clear solution.

Purity/Purification

Greater than 85% as determined by SDS-PAGE.

Molecular Weight

33,604 Da

OMIM

187950

3D Structure

ModBase 3D Structure for P40225

Product Categories/Family for TPO recombinant protein

Cytokines and Growth Factors

Other Notes

Small volumes of TPO recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TPO purchase

MBS140947 is a recombinant protein targeting TPO. Also known as Recombinant Human Thrombopoietin, His Tag. Host: Sf9 Insect Cells.

Additional Details

NCBI/Uniprot data below describe general gene information for TPO. It may not necessarily be applicable to this product.

NCBI GI #

4507493

NCBI GeneID

7066

NCBI Accession #

NP_000451.1

UniProt Primary Accession #

P40225

UniProt Secondary Accession #

Q13020; Q15790; Q15791; Q15792; A1L3Y0; B7ZLR8; B9EGA8

UniProt Related Accession #

P40225

GenBank Nucleotide #

NM_000460.3

NCBI Official Full Name

thrombopoietin isoform 1

NCBI Official Synonym Full Names

thrombopoietin

NCBI Official Symbol

THPO

NCBI Official Synonym Symbols

ML; TPO; MGDF; MKCSF; MPLLG; THCYT1

UniProt Protein Name

Thrombopoietin

UniProt Synonym Protein Names

C-mpl ligand; ML; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; MGDF; Myeloproliferative leukemia virus oncogene ligand

Protein Family

Thyroid peroxidase

UniProt Gene Name

THPO

UniProt Synonym Gene Names

MGDF; ML; MGDF

UniProt Entry Name

TPO_HUMAN

NCBI Protein Information

thrombopoietin

UniProt Comments for TPO

THPO: Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. Defects in THPO are the cause of thrombocythemia type 1 (THCYT1). A myeloproliferative disorder characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications. Belongs to the EPO/TPO family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3q27

Molecular Function: growth factor activity

Biological Process: multicellular organismal development; positive regulation of megakaryocyte differentiation; positive regulation of protein amino acid phosphorylation; positive regulation of protein kinase B signaling cascade

Disease: Thrombocythemia 1

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TPO recombinant protein

Reference Product	PubMed Publications
MPL recombinant protein	>34 publications with TPO and MPL
JAK2 recombinant protein	>4 publications with TPO and JAK2
STAT3 recombinant protein	>1 publications with TPO and STAT3

Pathways associated with TPO recombinant protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Platelet Aggregation (Plug Formation) Pathway antibodies	Platelet Aggregation (Plug Formation) Pathway Diagram
Platelet Activation, Signaling And Aggregation Pathway antibodies	Platelet Activation, Signaling And Aggregation Pathway Diagram

Diseases associated with TPO recombinant protein

Disease Name	Pubmed Publications
Thrombocytosis Antibodies	>11 publications with TPO and Thrombocytosis
Anemia Antibodies	>8 publications with TPO and Anemia
Hemorrhage Antibodies	>3 publications with TPO and Hemorrhage
Lung Neoplasms Antibodies	>3 publications with TPO and Lung Neoplasms
Disease Models, Animal Antibodies	>3 publications with TPO and Disease Models, Animal
Neurobehavioral Manifestations Antibodies	>2 publications with TPO and Neurobehavioral Manifestations
Growth Disorders Antibodies	>2 publications with TPO and Growth Disorders
Thrombocythemia, Essential Antibodies	>2 publications with TPO and Thrombocythemia, Essential
Precancerous Conditions Antibodies	>1 publications with TPO and Precancerous Conditions
Prenatal Injuries Antibodies	>1 publications with TPO and Prenatal Injuries

Organs/Tissues associated with TPO recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>7 publications with TPO and Liver
Connective Tissue Antibodies	>1 publications with TPO and Connective Tissue