Human NNT1 Active Protein – Cat# MBS140950

Neurotrophin-1 (NNT1) Human Active Protein

Name: NNT1 Active Protein; Neurotrophin-1; Human; MyBioSource
Brand: MyBioSource
SKU: MBS140950
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS140950

Description: Neurotrophin-1 Human Recombinant (28-225) produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 199 amino acids and having a molecular mass of 22kDa. The NNT-1 is purified by proprietary chromatographic techniques. More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Neurotrophin-1 (NNT1), Active Protein

Full Product Name

Recombinant Human Neurotrophin-1

Product Gene Name

NNT1 active protein

Product Synonym Names

NNT1 Human; Neurotrophin-1 Human Recombinant; Cardiotrophin-Like Cytokine Factor 1; Novel Neurotrophin-1; BSF3; CLC; CRLF1 Associated Cytokine-Like Factor 1; B-Cell Stimulating Factor 3; B-Cell-Stimulating Factor 3; BSF-3; NNT-1; NNT1; Neurotrophin-1/B-Cell Stimulating Factor-3; Cold-Induced Sweating Syndrome 2; B-Cell Stimulatory Factor 3; CISS2; NR6; CLCF1

Sequence

MLNRTGDPGP GPSIQKTYDL TRYLEHQLRS LAGTYLNYLG PPFNEPDFNP PRLGAETLPR ATVDLEVWRS LNDKLRLTQN YEAYSHLLCY LRGLNRQAAT AELRRSLAHF CTSLQGLLGS IAGVMAALGY PLPQPLPGTE PTWTPGPAHS DFLQKMDDFW LLKELQTWLW RSAKDFNRLK KKMQPPAAAV TLHLGAHGF

Host

E Coli

Form/Format

NNT-1 protein was lyophilized from a 0.2 um filtered solution in Acetonitrile and TFA.

Purity/Purification

Greater than 95.0% as determined by SDS-PAGE.

Preparation and Storage

Lyophilized Neurotrophin-1 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution NNT1 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

OMIM

607672

3D Structure

ModBase 3D Structure for Q9UBD9

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

The ED₅₀, as measured in a cell proliferation assay using human TF-1 cells transfected with human CNTF Ralpha, is less than 15ng/ml.

Solubility

It is recommended to reconstitute the lyophilized NNT1 in sterile 18M-cm H2O not less than 0.5mg/ml, which can then be further diluted to other aqueous solutions.

Physical Apperance

Sterile Filtered White lyophilized (freeze-dried) powder.

Product Categories/Family for NNT1 active protein

Cytokines and Growth Factors

Other Notes

Small volumes of NNT1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NNT1 purchase

MBS140950 is an active protein targeting NNT1. Also known as Recombinant Human Neurotrophin-1. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for NNT1. It may not necessarily be applicable to this product.

NCBI GI #

261245022

NCBI GeneID

23529

NCBI Accession #

NP_001159684.1

UniProt Primary Accession #

Q9UBD9

UniProt Secondary Accession #

Q6NZA4; B4DNT4

UniProt Related Accession #

Q9UBD9

GenBank Nucleotide #

NM_001166212.1

NCBI Official Full Name

cardiotrophin-like cytokine factor 1 isoform 2

NCBI Official Synonym Full Names

cardiotrophin-like cytokine factor 1

NCBI Official Symbol

CLCF1

NCBI Official Synonym Symbols

CLC; NR6; BSF3; NNT1; BSF-3; CISS2; NNT-1

UniProt Protein Name

Cardiotrophin-like cytokine factor 1

UniProt Synonym Protein Names

B-cell-stimulating factor 3; BSF-3; Novel neurotrophin-1; NNT-1

Protein Family

Protein N-methyltransferase

UniProt Gene Name

CLCF1

UniProt Synonym Gene Names

BSF3; CLC; NNT1; BSF-3; NNT-1

UniProt Entry Name

CLCF1_HUMAN

NCBI Protein Information

cardiotrophin-like cytokine factor 1

UniProt Comments for NNT1

CLCF1: Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor. Defects in CLCF1 are the cause of cold-induced sweating syndrome type 2 (CISS2). Cold-induced sweating syndrome (CISS) is an autosomal recessive disorder characterized by profuse sweating induced by cool surroundings (temperatures of 7 to 18 degrees Celsius). Additional abnormalities include a high- arched palate, nasal voice, depressed nasal bridge, inability to fully extend the elbows and kyphoscoliosis. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q13.3

Cellular Component: extracellular region

Molecular Function: ciliary neurotrophic factor receptor binding; cytokine activity; growth factor activity; protein binding; protein heterodimerization activity; receptor binding

Biological Process: B cell differentiation; cell surface receptor linked signal transduction; JAK-STAT cascade; negative regulation of neuron apoptosis; positive regulation of astrocyte differentiation; positive regulation of B cell proliferation; positive regulation of cell proliferation; positive regulation of immunoglobulin production; positive regulation of isotype switching to IgE isotypes; positive regulation of tyrosine phosphorylation of Stat3 protein

Disease: Cold-induced Sweating Syndrome 2

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with NNT1 active protein

Products by Pathway	Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
IL-6-type Cytokine Receptor Ligand Interactions Pathway antibodies	IL-6-type Cytokine Receptor Ligand Interactions Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Interleukin-6 Family Signaling Pathway antibodies	Interleukin-6 Family Signaling Pathway Diagram
Signaling By Interleukins Pathway antibodies	Signaling By Interleukins Pathway Diagram

Diseases associated with NNT1 active protein

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>2 publications with NNT1 and Cardiovascular Diseases
Seizures Antibodies	>2 publications with NNT1 and Seizures
Inflammation Antibodies	>2 publications with NNT1 and Inflammation
Lung Diseases Antibodies	>1 publications with NNT1 and Lung Diseases
Fibrosis Antibodies	>1 publications with NNT1 and Fibrosis
Lung Neoplasms Antibodies	>1 publications with NNT1 and Lung Neoplasms
Kidney Diseases Antibodies	>1 publications with NNT1 and Kidney Diseases
Necrosis Antibodies	>1 publications with NNT1 and Necrosis

Organs/Tissues associated with NNT1 active protein

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>5 publications with NNT1 and Nerve
Brain Antibodies	>3 publications with NNT1 and Brain
Skin Antibodies	>3 publications with NNT1 and Skin
Liver Antibodies	>1 publications with NNT1 and Liver
Bone Marrow Antibodies	>1 publications with NNT1 and Bone Marrow
Bone Antibodies	>1 publications with NNT1 and Bone
Lung Antibodies	>1 publications with NNT1 and Lung
Kidney Antibodies	>1 publications with NNT1 and Kidney