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Cyclin-Dependent Kinase Inhibitor 2a, Isoform 3 (CDKN2A) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1409562

This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors… More details

$825 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Cyclin-dependent kinase inhibitor 2A, isoform 3 (Cdkn2a), Recombinant Protein
Full Product Name
Recombinant Mouse Cyclin-dependent kinase inhibitor 2A, isoform 3 (Cdkn2a)
Product Gene Name
Cdkn2a recombinant protein
Product Synonym Gene Name
Cdkn2a
Sequence
MGRRFLVTVR IQRAGRPLQE RVFLVKFVRS RRPRTASCAL AFVNMLLRLE RILRRGPHRN PGPGDDDGQR SRSSSSAQLR CRFELRGPHY LLPPGARRSA GRLPGHAGGA ARVRGSAGCA RCLGSPAARL GPRAGTSRHR AIFAFRWVLF VFRWVVFVYR WERRPDRRA
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
17,941 Da
Sequence Positions
1-169, full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q64364
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Cdkn2a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Cdkn2a purchase

MBS1409562 is a recombinant protein targeting Cdkn2a. Also known as Recombinant Mouse Cyclin-dependent kinase inhibitor 2A, isoform 3 (Cdkn2a). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Cdkn2a. It may not necessarily be applicable to this product.

NCBI GI #
6753390
NCBI GeneID
12578
NCBI Accession #
NP_034007.1
UniProt Primary Accession #
Q64364
UniProt Secondary Accession #
Q4U255; Q9QXC7; Q9R051
UniProt Related Accession #
P51480; Q64364
GenBank Nucleotide #
NM_009877.2
NCBI Official Full Name
cyclin-dependent kinase inhibitor 2A p19ARF
NCBI Official Synonym Full Names
cyclin-dependent kinase inhibitor 2A
NCBI Official Symbol
Cdkn2a
NCBI Official Synonym Symbols
Arf; p16; MTS1; Pctr1; p19ARF; p16INK4a; p19<ARF>; ARF-INK4a; INK4a-ARF; Ink4a/Arf; p16(INK4a)
UniProt Protein Name
Tumor suppressor ARF
UniProt Synonym Protein Names
Alternative reading frame; ARF; Cyclin-dependent kinase inhibitor 2A; p19ARF
Protein Family
Cyclin-dependent kinase inhibitor
UniProt Gene Name
Cdkn2a
UniProt Synonym Gene Names
ARF
NCBI Protein Information
cyclin-dependent kinase inhibitor 2A

UniProt Comments for Cdkn2a

Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination (). Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development. Isoform smARF may be involved in regulation of autophagy and caspase-independent cell death; the short-lived mitochondrial isoform is stabilized by C1QBP.
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Research Articles on Cdkn2a

1. Data indicate the critical role of ARF in the modulation of tumor microenvironment.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Cdkn2a recombinant protein

 Reference Product  PubMed Publications
 Trp53 recombinant protein  >2031 publications with Cdkn2a and Trp53
 Cdk4 recombinant protein  >715 publications with Cdkn2a and Cdk4
 Myc recombinant protein  >436 publications with Cdkn2a and Myc
 Mdm2 recombinant protein  >334 publications with Cdkn2a and Mdm2
 Rassf1 recombinant protein  >215 publications with Cdkn2a and Rassf1
 Bmi1 recombinant protein  >120 publications with Cdkn2a and Bmi1
 Bcl2 recombinant protein  >85 publications with Cdkn2a and Bcl2
 Pdgfrb recombinant protein  >21 publications with Cdkn2a and Pdgfrb
 Mdm4 recombinant protein  >15 publications with Cdkn2a and Mdm4
 Hras1 recombinant protein  >1 publications with Cdkn2a and Hras1

Pathways associated with Cdkn2a recombinant protein

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Signaling Pathway antibodies  Cell Cycle Signaling Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 G1 To S Cell Cycle Control Pathway antibodies  G1 To S Cell Cycle Control Pathway Diagram

Diseases associated with Cdkn2a recombinant protein

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >1389 publications with Cdkn2a and Adenocarcinoma
 Carcinoma, Squamous Cell Antibodies  >1319 publications with Cdkn2a and Carcinoma, Squamous Cell
 Urogenital Neoplasms Antibodies  >1317 publications with Cdkn2a and Urogenital Neoplasms
 Melanoma Antibodies  >1077 publications with Cdkn2a and Melanoma
 Lymphoma Antibodies  >755 publications with Cdkn2a and Lymphoma
 Lung Neoplasms Antibodies  >710 publications with Cdkn2a and Lung Neoplasms
 Glioma Antibodies  >533 publications with Cdkn2a and Glioma
 Pancreatic Neoplasms Antibodies  >499 publications with Cdkn2a and Pancreatic Neoplasms
 Breast Neoplasms Antibodies  >476 publications with Cdkn2a and Breast Neoplasms
 Brain Neoplasms Antibodies  >462 publications with Cdkn2a and Brain Neoplasms

Organs/Tissues associated with Cdkn2a recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >869 publications with Cdkn2a and Lung
 Mixed Antibodies  >108 publications with Cdkn2a and Mixed
 Embryonic Tissue Antibodies  >102 publications with Cdkn2a and Embryonic Tissue
 Connective Tissue Antibodies  >66 publications with Cdkn2a and Connective Tissue
 Joint Antibodies  >66 publications with Cdkn2a and Joint
 Mammary Gland Antibodies  >54 publications with Cdkn2a and Mammary Gland
 Spleen Antibodies  >39 publications with Cdkn2a and Spleen
 Uncharacterized Tissue Antibodies  >1 publications with Cdkn2a and Uncharacterized Tissue
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