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Fibroblast Growth Factor-8 (FGF8) Mouse Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS140958

Introduction: FGF8 is part of the fibroblast growth factor family. FGF family members have wide mitogenic and cell survival activities, and participate in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue… More details

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Product Overview

Online Datasheet in PDF
Product Name
Fibroblast Growth Factor-8 (FGF8), Active Protein
Full Product Name
Recombinant Mouse Fibroblast Growth Factor-8, 194 a.a.
Product Gene Name
FGF8 active protein
Product Synonym Gene Name
mFGF8
Product Synonym Names
FGF 8 Mouse, 194 a.a.; Fibroblast Growth Factor-8 Mouse Recombinant, 194 a.a.; FGF8B; FGF-8B; FGF8-B; KAL6; HBGF-8; HBGF8; AIGF; HBGF-8; MGC149376; fibroblast growth factor 8
Sequence
MQVTVQSSPN FTQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANK RINAMAEDGD PFAKLIVETD TFGSRVRVRG AETGLYICMN KKGKLIAKSN GKGKDCVFTE IVLENNYTAL QNAKYEGWYM AFTRKGRPRK GSKTRQHQRE VHFMKRLPRG HHTTEQSLRF EFLNYPPFTR SLRGSQRTWA PEPR
Form/Format
Lyophilized from a concentrated (1mg/ml) solution containing 5mM Na3PO4 and 50 mM NaCl, pH 7.5.
Sterile Filtered White lyophilized (freeze-dried) powder.
Purity/Purification
Greater than 97.0% as determined by analysis by SDS-PAGE.
Preparation and Storage
Lyophilized FGF 8 although stable at room temperature for 3 weeks, should be stored desiccated below -18?C. Upon reconstitution FGF 8 should be stored at 4?C between 2-7 days and for future use below -18?C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Molecular Weight
23,522 Da
3D Structure
ModBase 3D Structure for P37237
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Source
Escherichia Coli
Biological Activity
The ED50, as determined by its ability to induce proliferation of mouse 3T3 fibroblasts, is 5-7ng/ml, corresponding to a specific activity of 2 x 105units/mg
Solubility
It is recommended to reconstitute the lyophilized FGF 8 in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Product Categories/Family for FGF8 active protein

Cytokines and Growth Factors

Other Notes

Small volumes of FGF8 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FGF8 purchase

MBS140958 is an active protein targeting FGF8. Also known as Recombinant Mouse Fibroblast Growth Factor-8, 194 a.a..

Additional Details

NCBI/Uniprot data below describe general gene information for FGF8. It may not necessarily be applicable to this product.

NCBI GI #
261599076
NCBI GeneID
14179
NCBI Accession #
NP_001159834.1
UniProt Primary Accession #
P37237
UniProt Related Accession #
P37237
GenBank Nucleotide #
NM_001166362.1
NCBI Official Full Name
fibroblast growth factor 8 isoform 3
NCBI Official Synonym Full Names
fibroblast growth factor 8
NCBI Official Symbol
Fgf8
NCBI Official Synonym Symbols
Aigf; Fgf-8
UniProt Protein Name
Fibroblast growth factor 8
UniProt Synonym Protein Names
Androgen-induced growth factor; AIGF; Heparin-binding growth factor 8; HBGF-8
Protein Family
Fibroblast growth factor
UniProt Gene Name
Fgf8
UniProt Synonym Gene Names
Aigf; FGF-8; AIGF; HBGF-8
UniProt Entry Name
FGF8_MOUSE
NCBI Protein Information
fibroblast growth factor 8

UniProt Comments for FGF8

FGF8: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Defects in FGF8 are the cause of Kallmann syndrome type 6 (KAL6). Kallmann syndrome is a disorder that associates hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone- synthesizing neurons. In some patients other developmental anomalies can be present, which include renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. In some cases anosmia may be absent or inconspicuous. Defects in FGF8 are a cause of idiopathic hypogonadotropic hypogonadism (IHH). IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. Belongs to the heparin-binding growth factors family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Secreted; Secreted, signal peptide

Cellular Component: external side of plasma membrane

Molecular Function: chemoattractant activity

Biological Process: adrenocorticotropin hormone secreting cell differentiation; apoptosis; blood vessel remodeling; BMP signaling pathway; cell fate commitment; cell proliferation in forebrain; central nervous system neuron development; determination of left/right symmetry; dorsal/ventral axon guidance; embryonic development ending in birth or egg hatching; embryonic heart tube development; embryonic hindlimb morphogenesis; fibroblast growth factor receptor signaling pathway; forebrain dorsal/ventral pattern formation; forebrain morphogenesis; forebrain neuron development; generation of neurons; gonad development; heart development; heart looping; heart morphogenesis; induction of an organ; inner ear morphogenesis; kidney development; limb morphogenesis; lung development; male genitalia development; MAPKKK cascade; mesodermal cell migration; midbrain-hindbrain boundary development; motor axon guidance; negative regulation of apoptosis; negative regulation of cardiac muscle development; negative regulation of neuron apoptosis; neural plate morphogenesis; otic vesicle formation; pallium development; patterning of blood vessels; pharyngeal system development; positive regulation of cell proliferation; positive regulation of mitosis; positive regulation of organ growth; regulation of odontogenesis of dentine-containing teeth; response to oxidative stress; subpallium development; telencephalon development; thyroid gland development; thyroid stimulating hormone secreting cell differentiation; ureteric bud branching; Wnt receptor signaling pathway through beta-catenin
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FGF8 active protein

 Reference Product  PubMed Publications
 Bmp4 active protein  >137 publications with FGF8 and Bmp4
 Fgfr1 active protein  >126 publications with FGF8 and Fgfr1
 Otx2 active protein  >99 publications with FGF8 and Otx2
 Wnt1 active protein  >81 publications with FGF8 and Wnt1
 Gbx2 active protein  >65 publications with FGF8 and Gbx2
 Fgfr2 active protein  >50 publications with FGF8 and Fgfr2
 Msx1 active protein  >46 publications with FGF8 and Msx1
 Fgfr3 active protein  >37 publications with FGF8 and Fgfr3
 Fgfr4 active protein  >20 publications with FGF8 and Fgfr4
 Fgf15 active protein  >16 publications with FGF8 and Fgf15

Pathways associated with FGF8 active protein

 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Dopminergic Neurogenesis Pathway antibodies  Dopminergic Neurogenesis Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram

Diseases associated with FGF8 active protein

 Disease Name  Pubmed Publications
 Musculoskeletal Abnormalities Antibodies  >117 publications with FGF8 and Musculoskeletal Abnormalities
 Embryo Loss Antibodies  >97 publications with FGF8 and Embryo Loss
 Craniofacial Abnormalities Antibodies  >89 publications with FGF8 and Craniofacial Abnormalities
 Abnormalities, Multiple Antibodies  >63 publications with FGF8 and Abnormalities, Multiple
 Nervous System Diseases Antibodies  >63 publications with FGF8 and Nervous System Diseases
 Genital Diseases, Male Antibodies  >50 publications with FGF8 and Genital Diseases, Male
 Disease Models, Animal Antibodies  >48 publications with FGF8 and Disease Models, Animal
 Kallmann Syndrome Antibodies  >47 publications with FGF8 and Kallmann Syndrome
 Cardiovascular Abnormalities Antibodies  >39 publications with FGF8 and Cardiovascular Abnormalities
 Heart Defects, Congenital Antibodies  >35 publications with FGF8 and Heart Defects, Congenital

Organs/Tissues associated with FGF8 active protein

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >386 publications with FGF8 and Embryonic Tissue
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