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Mesoderm Development Candidate 2 (MESDC2) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS140965

Introduction: Mesoderm development candidate 2 (MESDC2) is required for formation of the primitive streak and mesoderm during embryogenesis. MESDC2 binds to the Wnt co-receptors LRP5 and LRP6 in the endoplasmic reticulum and is required for their proper… More details

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Product Overview

Online Datasheet in PDF
Product Name
Mesoderm Development Candidate 2 (MESDC2), Recombinant Protein
Full Product Name
Recombinant Mouse Mesoderm Development Candidate 2
Product Synonym Gene Name
mMESDC2
Product Synonym Names
MESDC2 Mouse; Mesoderm Development Candidate 2 Mouse Recombinant; LDLR chaperone MESD; Mesoderm development candidate 2; Mesoderm development protein; Mesdc2; Mesd
Sequence
MGSSHHH HHH SSGLVPRGSH MGSADT PGEA TPPPRKKKDI RDYNDADMAR LLEQWEKDDD IEEGDLPEHK RPSAPIDFSK LDPGKPESIL KMTKKGKTLM MFVTVSGNPT EKETEEITSL WQGSLFNANY DVQRFIVGSD RAIFMLRDGS YAWEIKDFLV SQDRCAEVTL EGQMYPGKGG GSKEKNKTKP EKAKKKEGDP KPRASKEDNR AGSRREDL
Host
E Coli
Form/Format
MESDC2 protein solution (1mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Sterile Filtered colorless solution.
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Molecular Weight
25,207 Da
3D Structure
ModBase 3D Structure for Q9ERE7

Other Notes

Small volumes of MESDC2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MESDC2 purchase

MBS140965 is a recombinant protein targeting MESDC2. Also known as Recombinant Mouse Mesoderm Development Candidate 2. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for MESDC2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
LDLR chaperone MESD
NCBI Official Synonym Full Names
mesoderm development candidate 2
NCBI Official Symbol
Mesdc2
NCBI Official Synonym Symbols
msd; mesd; AW537813; mKIAA0081; 2210015O11Rik
UniProt Protein Name
LDLR chaperone MESD
UniProt Synonym Protein Names
Mesoderm development candidate 2; Mesoderm development protein
Protein Family
UniProt Gene Name
Mesdc2
UniProt Synonym Gene Names
Mesd
UniProt Entry Name
MESD_MOUSE
NCBI Protein Information
LDLR chaperone MESD

UniProt Comments for MESDC2

MESDC2: Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Monomer. Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane. Belongs to the MESD family.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: plasma membrane

Molecular Function: low-density lipoprotein receptor binding

Biological Process: protein folding
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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