Y Box Binding Protein 1 (YBX1) Human Recombinant Protein

YB-1: a nuclear protein that binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors CCAAT-containing Y-box of HLA class II genes. Component of cytoplasmic messenger ribonucleoprotein particles (mRNPs). Interacts with AKT1, SFRS9, THOC4, MSH2, XRCC5, WRN and NCL. Can bind to DNA as a homomeric form, (EFI-A)n or as a heteromeric form in association with EFI-B. Homodimer in the presence of ATP. Involved in cisplatin resistance. Seems to be a negative regulatory factor. May play a role in both transcriptional and translational regulation of spermatogenesis. Found at very low levels at day 10 and levels increase at day 15 and persist throughout adulthood.

Protein type: RNA processing; RNA splicing; RNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 1p34

Cellular Component: cytoplasm; intracellular membrane-bound organelle; nuclear membrane; nucleoplasm; nucleus; ribonucleoprotein complex; stress granule; U12-dependent spliceosome

Molecular Function: DNA binding; double-stranded DNA binding; GTPase binding; protein binding; RNA binding; transcription factor activity

Biological Process: nuclear mRNA splicing, via spliceosome; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter