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Legumain (LGMN) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS140986

Introduction: Legumain, also known as LGMN is a lysosomal cysteine protease which is found in all mouse tissues, however it was mainly abundant in the kidney as well as placenta. LGMN plays an essential role in the endosomal/lysosomal degradation system as… More details

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Product Overview

Online Datasheet in PDF
Product Name
Legumain (LGMN), Recombinant Protein
Full Product Name
Recombinant Mouse Legumain
Product Gene Name
LGMN recombinant protein
Product Synonym Gene Name
mLGMN
Product Synonym Names
LGMN Mouse; Legumain Mouse Recombinant; Legumain; Asparaginyl endopeptidase; Protease; cysteine 1
Sequence
VPVGVDDPED GGKHWVVIVA GSNGWYNYRH QADACHAYQI IHRNGIPDEQ IIVMMYDDIA NSEENPTPGV VINRPNGTDV YKGVLKDYTG EDVTPENFLA VLRGDAEAVK GKGSGKVLKS GPRDHVFIYF TDHGATGILV FPNDDLHVKD LNKTIRYMYE HKMYQKMVFY IEACESGSMM NHLPDDINVY ATTAANPKES SYACYYDEER GTYLGDWYSV NWMEDSDVED LTKETLHKQY HLVKSHTNTS HVMQYGNKSI STMKVMQFQG MKHRASSPIS LPPVTHLDLT PSPDVPLTIL KRKLLRTNDV KESQNLIGQI QQFLDARHVI EKSVHKIVSL LAGFGETAER HLSERTMLTA HDCYQEAVTH FRTHCFNWHS VTYEHALRYL YVLANLCEAP YPIDRIEMAM DKVCLSHYLE HHHHHH
Host
Sf9 Baculovirus Cells
Form/Format
LGMN protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Sterile filtered colorless solution.
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Molecular Weight
49,373 Da
3D Structure
ModBase 3D Structure for O89017

Product Categories/Family for LGMN recombinant protein

Enzymes

Other Notes

Small volumes of LGMN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LGMN purchase

MBS140986 is a recombinant protein targeting LGMN. Also known as Recombinant Mouse Legumain. Host: Sf9 Baculovirus Cells.

Additional Details

NCBI/Uniprot data below describe general gene information for LGMN. It may not necessarily be applicable to this product.

NCBI GI #
7242187
NCBI GeneID
19141
NCBI Accession #
NP_035305.1
UniProt Primary Accession #
O89017
UniProt Related Accession #
O89017
GenBank Nucleotide #
NM_011175.2
NCBI Official Full Name
legumain
NCBI Official Synonym Full Names
legumain
NCBI Official Symbol
Lgmn
NCBI Official Synonym Symbols
AEP; Prsc1; AI746452; AU022324
UniProt Protein Name
Legumain
UniProt Synonym Protein Names
Asparaginyl endopeptidase; Protease, cysteine 1
Protein Family
Legumain
UniProt Gene Name
Lgmn
UniProt Synonym Gene Names
Prsc1
UniProt Entry Name
LGMN_MOUSE
NCBI Protein Information
legumain

UniProt Comments for LGMN

LGMN: Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Belongs to the peptidase C13 family.

Protein type: EC 3.4.22.34; Protease

Cellular Component: apical part of cell; late endosome; lysosome

Molecular Function: cysteine-type endopeptidase activity; peptidase activity

Biological Process: negative regulation of multicellular organism growth; negative regulation of neuron apoptosis; proteolysis; proteolysis involved in cellular protein catabolic process; receptor catabolic process; renal system process; response to acidity; vacuolar protein processing
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with LGMN recombinant protein

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 MHC Class II Antigen Presentation Pathway antibodies  MHC Class II Antigen Presentation Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Fat-soluble Vitamins Pathway antibodies  Metabolism Of Fat-soluble Vitamins Pathway Diagram

Diseases associated with LGMN recombinant protein

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >1 publications with LGMN and Breast Neoplasms
 Liver Neoplasms Antibodies  >1 publications with LGMN and Liver Neoplasms
 Prenatal Injuries Antibodies  >1 publications with LGMN and Prenatal Injuries
 Carcinoma, Hepatocellular Antibodies  >1 publications with LGMN and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >1 publications with LGMN and Liver Diseases
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with LGMN and Prenatal Exposure Delayed Effects
 Inflammation Antibodies  >1 publications with LGMN and Inflammation

Organs/Tissues associated with LGMN recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with LGMN and Blood
 Embryonic Tissue Antibodies  >3 publications with LGMN and Embryonic Tissue
 Liver Antibodies  >1 publications with LGMN and Liver
 Brain Antibodies  >1 publications with LGMN and Brain
 Kidney Antibodies  >1 publications with LGMN and Kidney
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