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BRCA1-Associated RING Domain Protein 1 (BARD1) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1410229

This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT… More details

$1635 / 0.02 mg (E-Coli) +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BRCA1-associated RING domain protein 1 (Bard1), Recombinant Protein
Full Product Name
Recombinant Rat BRCA1-associated RING domain protein 1 (Bard1)
Product Gene Name
Bard1 recombinant protein
Product Synonym Gene Name
Bard1
Sequence
MPRRPPRVCS GNKPPPVPAM EPATDGLWAH SRAALARLEK LLRCSRCANI LREPVCLGGC EHIFCSGCIS DCVGSGCPVC HTPAWILDLK INRQLDSMIQ LYSKLQNLLH DNKGSDSKDD TSRASLFGDA ERKKNSVKMW FSPRSKKIRC VVNKVSVQTQ PQKAKDDKAQ EASVFEFVSA TPPVVVSTRA KTASRTSAKK HPKKSVAKIN REGNFRPETR DSRFDSKEKL KEEKVVSFSQ TLVMENSRVN GEIDLLASGS VVESVFSGSF AEVSLPLAEH IVSPDTVSKS EEAPEKKVCV EDRCPVGSDG NPKGCHRPPT STSKKCGSNV PSASGEIREP TLLAENVVLV DCSSLPSGRL QVDVTLRRQS NASDDSLSLS PGTPPSLLNN STHRQMMSKP STVKLSSGIP ARKRNHRGET LLHIASIKGD ISSVEYLLQN GNDPNVKDHA GWTPLHEACS HGHLKIVELL LQHNALVNTT GYHNDSPLHD AAKNGHIDIV KVLLSHGASR NAVNIFGERP VDYTDAENIR SLLLLPEKTD SFSTSQCSVQ VNTGQRKSGP LVLIGSGLSS QQQKLLSKLE TVLKAKKCAE FDNTVTHVIV PDEEAQSTLK CMLGILNGCW VLKFDWVKAC LDSQEREQEE KYEVPGGPQR SRLNREQLLP KLFDGCYFFL GGNFKHHPKE DLLKLIAAAG GRILSRKPKP DSDVTQTINT VAYHAKPDSD QRFCTQYIVY EDLFNCHPER VRQGKVWMAP STWLISCVMA FELLPLDS
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
84,548 Da
Sequence Positions
1-768, full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q9QZH2
Species
Rat
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Bard1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Bard1 purchase

MBS1410229 is a recombinant protein targeting Bard1. Also known as Recombinant Rat BRCA1-associated RING domain protein 1 (Bard1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Bard1. It may not necessarily be applicable to this product.

NCBI GI #
12018308
NCBI GeneID
64557
NCBI Accession #
NP_072144.1
UniProt Primary Accession #
Q9QZH2
UniProt Related Accession #
Q9QZH2
GenBank Nucleotide #
NM_022622.1
NCBI Official Full Name
BRCA1-associated RING domain protein 1
NCBI Official Synonym Full Names
BRCA1 associated RING domain 1
NCBI Official Symbol
Bard1
UniProt Protein Name
BRCA1-associated RING domain protein 1
UniProt Synonym Protein Names
RING-type E3 ubiquitin transferase BARD1Curated
Protein Family
BRCA1-associated RING domain protein
UniProt Gene Name
Bard1
UniProt Synonym Gene Names
BARD-1
NCBI Protein Information
BRCA1-associated RING domain protein 1

UniProt Comments for Bard1

E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.
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Research Articles on Bard1

1. Assignment of the BRCA1-associated RING domain gene (Bard1) to rat chromosome 9q34 by in situ hybridization and radiation hybrid mapping

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Bard1 recombinant protein

 Products by Pathway  Pathway Diagram
 NFE2L2 Pathway antibodies  NFE2L2 Pathway Diagram

Diseases associated with Bard1 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >114 publications with Bard1 and Neoplasms
 Breast Neoplasms Antibodies  >92 publications with Bard1 and Breast Neoplasms
 Skin Diseases Antibodies  >79 publications with Bard1 and Skin Diseases
 Ovarian Neoplasms Antibodies  >48 publications with Bard1 and Ovarian Neoplasms
 Mammary Neoplasms, Animal Antibodies  >8 publications with Bard1 and Mammary Neoplasms, Animal
 Neoplasms, Experimental Antibodies  >8 publications with Bard1 and Neoplasms, Experimental
 Anemia Antibodies  >6 publications with Bard1 and Anemia
 Adenocarcinoma Antibodies  >6 publications with Bard1 and Adenocarcinoma
 Ataxia Antibodies  >6 publications with Bard1 and Ataxia
 Disease Models, Animal Antibodies  >5 publications with Bard1 and Disease Models, Animal

Organs/Tissues associated with Bard1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >2 publications with Bard1 and Liver
 Prostate Antibodies  >2 publications with Bard1 and Prostate
 Embryonic Tissue Antibodies  >1 publications with Bard1 and Embryonic Tissue
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