Human LGMN Recombinant Protein – Cat# MBS141063

Legumain (LGMN) Human Recombinant Protein

Name: LGMN Recombinant Protein; Legumain; Human; MyBioSource
Brand: MyBioSource
SKU: MBS141063
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS141063

Introduction: Legumain, also known as LGMN, is a cysteine endopeptidase which demonstrates strict specificity for hydrolysis of asparaginyl bonds. Furthermore, LGMN can also cleave aspartyl bonds slowly, in particular under acidic conditions. LGMN plays an… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Legumain (LGMN), Recombinant Protein

Full Product Name

Recombinant Human Legumain

Product Gene Name

LGMN recombinant protein

Product Synonym Names

Legumain, PRSC1, Protease, Cysteine, 1 (Legumain), Asparaginyl Endopeptidase, Protease, Cysteine 1, EC 3.4.22.34, Cysteine Protease 1, LGMN1, AEP.

Sequence

VPIDDPEDGG KHWVVIVAGS NGWYNYRHQA DACHAYQIIH RNGIPDEQIV VMMYDDIAYS EDNPTPGIVI NRPNGTDVYQ GVPKDYTGED VTPQNFLAVL RGDAEAVKGI GSGKVLKSGP QDHVFIYFTD HGSTGILVFP NEDLHVKDLN ETIHYMYKHK MYRKMVFYIE ACESGSMMNH LPDNINVYAT TAANPRESSY ACYYDEKRST YLGDWYSVNW MEDSDVEDLT KETLHKQYHL VKSHTNTSHV MQYGNKTIST MKVMQFQGMK RKASSPVPLP PVTHLDLTPS PDVPLTIMKR KLMNTNDLEE SRQLTEEIQR HLDARHLIEK SVRKIVSLLA ASEAEVEQLL SERAPLTGHS CYPEALLHFR THCFNWHSPT YEYALRHLYV LVNLCEKPYP LHRIKLSMDH VCLGHYH HHH HH.

Host

Sf9, Baculovirus Cells

Form/Format

LGMN protein solution (1mg/ml) contains Phosphate buffered saline (pH7.4) and 10% glycerol.
Sterile filtered colorless solution.

Purity/Purification

Greater than 95.0% as determined by SDS-PAGE.

Preparation and Storage

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.

Molecular Weight

42,008 Da

OMIM

602620

3D Structure

ModBase 3D Structure for Q99538

Physical Appearance

Sterile filtered colorless solution.

Product Categories/Family for LGMN recombinant protein

Enzymes

Other Notes

Small volumes of LGMN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LGMN purchase

MBS141063 is a recombinant protein targeting LGMN. Also known as Recombinant Human Legumain. Host: Sf9, Baculovirus Cells.

Additional Details

NCBI/Uniprot data below describe general gene information for LGMN. It may not necessarily be applicable to this product.

NCBI GI #

56682964

NCBI GeneID

5641

NCBI Accession #

NP_001008530.1

UniProt Primary Accession #

Q99538

UniProt Secondary Accession #

O00123; Q86TV2; Q86TV3; Q9BTY1

UniProt Related Accession #

Q99538

GenBank Nucleotide #

NM_001008530.2

NCBI Official Full Name

legumain preproprotein

NCBI Official Synonym Full Names

legumain

NCBI Official Symbol

LGMN

NCBI Official Synonym Symbols

AEP; LGMN1; PRSC1

UniProt Protein Name

Legumain

UniProt Synonym Protein Names

Asparaginyl endopeptidase; Protease, cysteine 1

Protein Family

Legumain

UniProt Gene Name

LGMN

UniProt Synonym Gene Names

PRSC1

UniProt Entry Name

LGMN_HUMAN

NCBI Protein Information

legumain

UniProt Comments for LGMN

LGMN: Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Belongs to the peptidase C13 family.

Protein type: EC 3.4.22.34; Protease

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: lysosomal lumen; lysosome

Molecular Function: cysteine-type endopeptidase activity; peptidase activity

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; negative regulation of neuron apoptosis; proteolysis; proteolysis involved in cellular protein catabolic process; receptor catabolic process; renal system process; toll-like receptor signaling pathway; vacuolar protein processing; vitamin D metabolic process

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with LGMN recombinant protein

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Antigen Processing And Presentation Pathway antibodies	Antigen Processing And Presentation Pathway Diagram
Antigen Processing And Presentation Pathway antibodies	Antigen Processing And Presentation Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram
MHC Class II Antigen Presentation Pathway antibodies	MHC Class II Antigen Presentation Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Fat-soluble Vitamins Pathway antibodies	Metabolism Of Fat-soluble Vitamins Pathway Diagram

Diseases associated with LGMN recombinant protein

Disease Name	Pubmed Publications
Breast Neoplasms Antibodies	>1 publications with LGMN and Breast Neoplasms
Liver Neoplasms Antibodies	>1 publications with LGMN and Liver Neoplasms
Prenatal Injuries Antibodies	>1 publications with LGMN and Prenatal Injuries
Carcinoma, Hepatocellular Antibodies	>1 publications with LGMN and Carcinoma, Hepatocellular
Liver Diseases Antibodies	>1 publications with LGMN and Liver Diseases
Prenatal Exposure Delayed Effects Antibodies	>1 publications with LGMN and Prenatal Exposure Delayed Effects
Inflammation Antibodies	>1 publications with LGMN and Inflammation

Organs/Tissues associated with LGMN recombinant protein

Organ/Tissue Name	Pubmed Publications
Embryonic Tissue Antibodies	>3 publications with LGMN and Embryonic Tissue
Blood Antibodies	>3 publications with LGMN and Blood
Uterus Antibodies	>2 publications with LGMN and Uterus
Nerve Antibodies	>1 publications with LGMN and Nerve
Umbilical Cord Antibodies	>1 publications with LGMN and Umbilical Cord
Pancreas Antibodies	>1 publications with LGMN and Pancreas
Liver Antibodies	>1 publications with LGMN and Liver
Kidney Antibodies	>1 publications with LGMN and Kidney
Brain Antibodies	>1 publications with LGMN and Brain