Annexin A5 (ANXA5) Mouse Recombinant Protein

ANXA5: a calcium/phospholipid-binding protein and an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. The binding of labeled ANXA5 to phosphatidylserine is used as a marker of apoptosis. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.

Protein type: Apoptosis; Calcium-binding; Inhibitor; Lipid-binding

Cellular Component: cell projection; cell soma; cytoplasm; cytosol; dendrite; endoplasmic reticulum; external side of plasma membrane; extracellular space; focal adhesion; intracellular; membrane; nerve terminal; nucleus; perikaryon; plasma membrane; sarcolemma; synaptic vesicle; Z disc

Molecular Function: calcium-dependent phospholipid binding; calcium-transporting ATPase activity; peptide hormone binding; protein binding; receptor tyrosine kinase binding

Biological Process: negative regulation of blood coagulation; positive regulation of apoptosis; protein homooligomerization; response to calcium ion; response to organic substance