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Hypermethylated in Cancer 1 Protein (HIC1) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1410822

MBS1410822 is a recombinant protein targeting Hic1. Also known as Recombinant Mouse Hypermethylated in cancer 1 protein (Hic1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1595 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Hypermethylated in cancer 1 protein (Hic1), Recombinant Protein
Full Product Name
Recombinant Mouse Hypermethylated in cancer 1 protein (Hic1)
Product Gene Name
Hic1 recombinant protein
Product Synonym Gene Name
Hic1
Sequence
MTFPEADILL KSGECAGQTM LDTMEAPGHS RQLLLQLNNQ RTKGFLCDVI IVVQNALFRA HKNVLAASSA YLKSLVVHDN LLNLDHDMVS PAVFRLVLDF IYTGRLTDSV EAAAAAAVAP GAEPSLGAVL AAASYLQIPD LVALCKKRLK RHGKYCHLRG GGSGGGGYAP YGRPGRGLRA ATPVIQACYS SPAGPPPPPA AEPPSGPDAA VNTHCAELYA SGPGPAASLC APERRCSPLC GLDLSKKSPP GSSVPERPLS ERELPPRPDS PPGAGPAVYK EPSLALPPLP PLPFQKLEEA VPTPDPFRGS GGSPGPEPPG RPDGSSLLYR WMKHEPGLGS YGDELVRDRG SPGERLEERG GDPAASPGGP PLGLVPPPRY PGSLDGPGTG ADGDDYKSSS EETGSSEDPS PPGGHLEGYP CPHLAYGEPE SFGDNLYVCI PCGKGFPSSE QLNAHVEAHV EEEEALYGRA EAAEVAAGAA GLGPPFGGGG DKVTGAPGGL GELLRPYRCA SCDKSYKDPA TLRQHEKTHW LTRPYPCTIC GKKFTQRGTM TRHMRSHLGL KPFACDACGM RFTRQYRLTE HMRIHSGEKP YECQVCGGKF AQQRNLISHM KMHAVGGAAG AAGALAGLGG LPGVPGPDGK GKLDFPEGVF AVARLTAEQL SLKQQDKAAA AELLAQTTHF LHDPKVALES LYPLAKFTAE LGLSPDKAAE VLSQGAHLAA GPDSRTIDRF SPT
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
76,828 Da
Sequence Positions
1-733, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q9R1Y5
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Hic1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Hic1. It may not necessarily be applicable to this product.

NCBI GI #
148228529
NCBI GeneID
15248
NCBI Accession #
NP_001091673.1
UniProt Primary Accession #
Q9R1Y5
UniProt Secondary Accession #
Q9R1Y6; Q9R2B0; B1ARH0
UniProt Related Accession #
Q9R1Y5
GenBank Nucleotide #
NM_001098203.1
NCBI Official Full Name
hypermethylated in cancer 1 protein isoform 2
NCBI Official Synonym Full Names
hypermethylated in cancer 1
NCBI Official Symbol
Hic1
NCBI Official Synonym Symbols
HIC-1; AA408311
UniProt Protein Name
Hypermethylated in cancer 1 protein
Protein Family
Hypermethylated in cancer 1 protein
UniProt Gene Name
Hic1
UniProt Synonym Gene Names
Hic-1
NCBI Protein Information
hypermethylated in cancer 1 protein

UniProt Comments for Hic1

Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex. Probably represses transcription from ACKR3, FGFBP1 and EFNA1.
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Research Articles on Hic1

1. HIC1 loss promotes prostate cancer metastasis by triggering epithelial-mesenchymal transition.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with Hic1 recombinant protein

 Disease Name  Pubmed Publications
 Gastrointestinal Neoplasms Antibodies  >32 publications with Hic1 and Gastrointestinal Neoplasms
 Breast Neoplasms Antibodies  >24 publications with Hic1 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >13 publications with Hic1 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >9 publications with Hic1 and Lung Neoplasms
 Neoplasm Metastasis Antibodies  >9 publications with Hic1 and Neoplasm Metastasis
 Medulloblastoma Antibodies  >9 publications with Hic1 and Medulloblastoma
 Polyps Antibodies  >8 publications with Hic1 and Polyps
 Ovarian Neoplasms Antibodies  >7 publications with Hic1 and Ovarian Neoplasms
 Central Nervous System Neoplasms Antibodies  >7 publications with Hic1 and Central Nervous System Neoplasms
 Lymphoma Antibodies  >7 publications with Hic1 and Lymphoma

Organs/Tissues associated with Hic1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >13 publications with Hic1 and Brain
 Lung Antibodies  >9 publications with Hic1 and Lung
 Embryonic Tissue Antibodies  >6 publications with Hic1 and Embryonic Tissue
 Intestine Antibodies  >5 publications with Hic1 and Intestine
 Liver Antibodies  >5 publications with Hic1 and Liver
 Bladder Antibodies  >2 publications with Hic1 and Bladder
 Pancreas Antibodies  >2 publications with Hic1 and Pancreas
 Eye Antibodies  >2 publications with Hic1 and Eye
 Heart Antibodies  >1 publications with Hic1 and Heart
 Mammary Gland Antibodies  >1 publications with Hic1 and Mammary Gland
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