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Cyclophilin-B (PPIB) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS141099

Introduction: Cyclophilin B (also known as PPIB, peptidylpropyl isomerase B) is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Cyclophilin-B (PPIB), Recombinant Protein
Full Product Name
Recombinant Human Cyclophilin-B, His Tag
Product Gene Name
PPIB recombinant protein
Product Synonym Names
Cyclophilin B Human, His; Cyclophilin-B Human Recombinant, His Tag; Peptidylprolyl isomerase B; PPIase; Rotamase; S-cyclophilin; PPIB; cyclophilin-like protein; peptidyl-prolyl cis-trans isomerase B; Cyclophilin B; SCYLP; CYPB; CYP-S1; MGC2224; MGC14109
Sequence
MKHHHHH HAS DEKKKGPKVT VKVYFDLRIG DEDVGRVIFG LFGKTVPKTV DNFVALATGE KGFGYKNSKF HRVIKDFMIQ GGDFTRGDGT GGKSIYGERF PDENFKLKHY GPGWVSMANA GKDTNGSQFF ITTVKTAWLD GKHVVFGKVL EGMEVVRKVE STKTDSRDKP LKDVIIADCG KIEVEKPFAI AKE.
Host
E Coli
Form/Format
Cyclophilin-B was filtered (0.4 um) and lyophilized in 20mM Tris buffer and 50mM NaCl, pH 7.5.
Filtered White lyophilized (freeze-dried) powder.
Purity/Purification
Purity as determined by densitometric image analysis is greater than 95%.
Preparation and Storage
Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.
Molecular Weight
23,743 Da
OMIM
123841
3D Structure
ModBase 3D Structure for P23284
Solubility
It is recommended to add 200 ul of deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Cyclophilin-B is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

Product Categories/Family for PPIB recombinant protein

Enzymes

Other Notes

Small volumes of PPIB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PPIB purchase

MBS141099 is a recombinant protein targeting PPIB. Also known as Recombinant Human Cyclophilin-B, His Tag. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PPIB. It may not necessarily be applicable to this product.

NCBI GI #
4758950
NCBI GeneID
5479
NCBI Accession #
NP_000933.1
UniProt Primary Accession #
P23284
UniProt Secondary Accession #
Q6IBH5; Q9BVK5; A8K534
UniProt Related Accession #
P23284
GenBank Nucleotide #
NM_000942.4
NCBI Official Full Name
peptidyl-prolyl cis-trans isomerase B
NCBI Official Synonym Full Names
peptidylprolyl isomerase B
NCBI Official Symbol
PPIB
NCBI Official Synonym Symbols
OI9; CYPB; SCYLP; CYP-S1; HEL-S-39
UniProt Protein Name
Peptidyl-prolyl cis-trans isomerase B
UniProt Synonym Protein Names
CYP-S1; Cyclophilin B; Rotamase B; S-cyclophilin; SCYLP
Protein Family
Probable peptidyl-prolyl cis-trans isomerase
UniProt Gene Name
PPIB
UniProt Synonym Gene Names
CYPB; PPIase B; SCYLP
UniProt Entry Name
PPIB_HUMAN
NCBI Protein Information
peptidyl-prolyl cis-trans isomerase B

UniProt Comments for PPIB

PPIB: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Defects in PPIB are the cause of osteogenesis imperfecta type 9 (OI9). OI9 is a connective tissue disorder characterized by bone fragility, low bone mass and bowing of limbs due to multiple fractures. Short limb dwarfism and blue sclerae are observed in some but not all patients. Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.

Protein type: Chaperone; Cyclophilin; EC 5.2.1.8; Isomerase; RNA-binding; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 15q21-q22

Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen; focal adhesion; membrane; nucleus; perinuclear region of cytoplasm

Molecular Function: collagen binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; protein complex binding; unfolded protein binding

Biological Process: positive regulation of multicellular organism growth; protein peptidyl-prolyl isomerization; protein stabilization

Disease: Osteogenesis Imperfecta, Type Ix
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PPIB recombinant protein

 Reference Product  PubMed Publications
 CRTAP recombinant protein  >23 publications with PPIB and CRTAP
 LEPRE1 recombinant protein  >21 publications with PPIB and LEPRE1
 SERPINH1 recombinant protein  >9 publications with PPIB and SERPINH1
 PDIA3 recombinant protein  >1 publications with PPIB and PDIA3

Pathways associated with PPIB recombinant protein

 Products by Pathway  Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Prolactin Signaling Pathway antibodies  Prolactin Signaling Pathway Diagram
 Syndecan-1-mediated Signaling Events Pathway antibodies  Syndecan-1-mediated Signaling Events Pathway Diagram

Diseases associated with PPIB recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >7 publications with PPIB and Nervous System Diseases
 Brain Diseases Antibodies  >5 publications with PPIB and Brain Diseases
 Inflammation Antibodies  >3 publications with PPIB and Inflammation
 Breast Neoplasms Antibodies  >2 publications with PPIB and Breast Neoplasms
 Carcinoma, Hepatocellular Antibodies  >2 publications with PPIB and Carcinoma, Hepatocellular
 Cardiovascular Diseases Antibodies  >1 publications with PPIB and Cardiovascular Diseases
 Liver Neoplasms Antibodies  >1 publications with PPIB and Liver Neoplasms
 Disease Models, Animal Antibodies  >1 publications with PPIB and Disease Models, Animal
 Kidney Diseases Antibodies  >1 publications with PPIB and Kidney Diseases
 Heart Diseases Antibodies  >1 publications with PPIB and Heart Diseases

Organs/Tissues associated with PPIB recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >22 publications with PPIB and Bone
 Blood Antibodies  >13 publications with PPIB and Blood
 Skin Antibodies  >12 publications with PPIB and Skin
 Connective Tissue Antibodies  >6 publications with PPIB and Connective Tissue
 Liver Antibodies  >4 publications with PPIB and Liver
 Brain Antibodies  >4 publications with PPIB and Brain
 Muscle Antibodies  >4 publications with PPIB and Muscle
 Heart Antibodies  >3 publications with PPIB and Heart
 Kidney Antibodies  >3 publications with PPIB and Kidney
 Pancreas Antibodies  >2 publications with PPIB and Pancreas
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