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Kallistatin (SERPINA4) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS141100

Introduction: Kallistatin (SERPINA4) inhibits human amidolytic and kininogenase activities of tissue kallikrein. This inhibition is attained by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and production of a… More details

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Product Overview

Online Datasheet in PDF
Product Name
Kallistatin (SERPINA4), Recombinant Protein
Full Product Name
Recombinant Human Kallistatin
Product Synonym Names
SERPINA4 Human; Kallistatin Human Recombinant; Serpin Peptidase Inhibitor; Clade A (Alpha-1 Antiproteinase; Antitrypsin) Member 4; PI4; KST; Serine (Or Cysteine) Proteinase Inhibitor; Clade A (Alpha-1 Antiproteinase; Antitrypsin); Member 4; Peptidase Inhibitor 4; Kallikrein Inhibitor; Serpin A4; PI-4; Protease Inhibitor 4 (Kallistatin); Kallistatin; KLST; KAL; SERPINA4
Sequence
QLHVEHDGES CSNSSHQQIL ETGEGSPSLK IAPANADFAF RFYYLIASET PGKNIFFSPL SISAAYAMLS LGACSHSRSQ ILEGLGFNLT ELSESDVHRG FQHLLHTLNL PGHGLETRVG SALFLSHNLK FLAKFLNDTM AVYEAKLFHT NFYDTVGTIQ LINDHVKKET RGKIVDLVSE LKKDVLMVLV NYIYFKALWE KPFISSRTTP KDFYVDENTT VRVPMMLQDQ EHHWYLHDRY LPCSVLRMDY KGDATVFFIL PNQGKMREIE EVLTPEMLMR WNNLLRKRNF YKKLELHLPK FSISGSYVLD QILPRLGFTD LFSKWADLSG ITKQQKLEAS KSFHKATLDV DEAGTEAAAA TSFAIKFFSA QTNRHILRFN RPFLVVIFST STQSVLFLGK VVDPTKP HHH HHHHHHH.
Host
HEK 293
Form/Format
SERPINA4 was filtered (0.4 um) and lyophilized from 0.5mg/ml solution in phosphate buffered saline pH 7.4 and 5% (w/v) Trehalose.
Filtered White lyophilized (freeze-dried) powder.
Purity/Purification
Purity as determined by densitometric image analysis is greater than 95%.
Preparation and Storage
Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.
Molecular Weight
48,542 Da
OMIM
147935
3D Structure
ModBase 3D Structure for P29622
Solubility
It is recommended to add 200 ul deionized water to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. SERPINA4 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

Other Notes

Small volumes of SERPINA4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SERPINA4 purchase

MBS141100 is a recombinant protein targeting SERPINA4. Also known as Recombinant Human Kallistatin. Host: HEK 293.

Additional Details

NCBI/Uniprot data below describe general gene information for SERPINA4. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
kallistatin isoform 1
NCBI Official Synonym Full Names
serpin family A member 4
NCBI Official Symbol
SERPINA4
NCBI Official Synonym Symbols
KAL; KST; PI4; KLST; PI-4; kallistatin
UniProt Protein Name
Kallistatin
UniProt Synonym Protein Names
Kallikrein inhibitor; Peptidase inhibitor 4; PI-4; Serpin A4
Protein Family
UniProt Gene Name
SERPINA4
UniProt Synonym Gene Names
KST; PI4; PI-4
UniProt Entry Name
KAIN_HUMAN
NCBI Protein Information
kallistatin

UniProt Comments for SERPINA4

SERPINA4: Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein. Belongs to the serpin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q32.13

Cellular Component: extracellular region; extracellular space

Biological Process: platelet degranulation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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