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Transforming Growth Factor-Beta 3 (TGFB3) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS141112

Introduction: Transforming growth factor betas (TGF Betas) mediate many cell-cell interactions that occur during embryonic development. Three TGF Betas have been identified in mammals. TGF Beta 1, TGF Beta 2 and TGF Beta 3 are each synthesized as precursor… More details

$250 / 0.005 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Transforming Growth Factor-Beta 3 (TGFB3), Recombinant Protein
Full Product Name
Recombinant Human Transforming Growth Factor-Beta 3 (24-412 a.a.)
Product Gene Name
TGFB3 recombinant protein
Product Synonym Names
TGFB3 (24-412 a.a.) Human; Transforming Growth Factor-Beta 3 (24-412 a.a.) Human Recombinant; Transforming Growth Factor; Beta 3; Prepro-Transforming Growth Factor Beta-3; TGF-Beta-3; ARVD1; RNHF; Arrhythmogenic Right Ventricular Dysplasia 1; Transforming Growth Factor Beta-3; TGF-Beta3; ARVD; Transforming growth factor beta-3; TGF-beta-3
Sequence
MGSSHHH HHH SSGLVPRGSH MGSLST CTTL DFGHIKKKRV EAIRGQILSK LRLTSPPEPT VMTHVPYQVL ALYNSTRELL EEMHGEREEG CTQENTESEY YAKEIHKFDM IQGLAEHNEL AVCPKGITSK VFRFNVSSVE KNRTNLFRAE FRVLRVPNPS SKRNEQRIEL FQILRPDEHI AKQRYIGGKN LPTRGTAEWL SFDVTDTVRE WLLRRESNLG LEISIHCPCH TFQPNGDILE NIHEVMEIKF KGVDNEDDHG RGDLGRLKKQ KDHHNPHLIL MMIPPHRLDN PGQGGQRKKR ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS
Host
E Coli
Form/Format
TGFB3 protein solution (0.5mg/ml) containing 20mM Tris-HCl (pH8.0) and 10% glycerol.
Sterile Filtered colorless solution.
Purity/Purification
Greater than 85.0% as determined by SDS-PAGE.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Molecular Weight
35,708 Da
OMIM
107970
3D Structure
ModBase 3D Structure for P10600

Product Categories/Family for TGFB3 recombinant protein

Cytokines and Growth Factors

Other Notes

Small volumes of TGFB3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TGFB3 purchase

MBS141112 is a recombinant protein targeting TGFB3. Also known as Recombinant Human Transforming Growth Factor-Beta 3 (24-412 a.a.). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for TGFB3. It may not necessarily be applicable to this product.

NCBI GI #
4507465
NCBI GeneID
7043
NCBI Accession #
NP_003230.1
UniProt Primary Accession #
P10600
UniProt Secondary Accession #
Q8WV88
UniProt Related Accession #
P10600
GenBank Nucleotide #
NM_003239.3
NCBI Official Full Name
transforming growth factor beta-3 preproprotein
NCBI Official Synonym Full Names
transforming growth factor beta 3
NCBI Official Symbol
TGFB3
NCBI Official Synonym Symbols
ARVD; LDS5; RNHF; ARVD1; TGF-beta3
UniProt Protein Name
Transforming growth factor beta-3
Protein Family
Transforming growth factor
UniProt Gene Name
TGFB3
UniProt Synonym Gene Names
TGF-beta-3; LAP
UniProt Entry Name
TGFB3_HUMAN
NCBI Protein Information
transforming growth factor beta-3

UniProt Comments for TGFB3

TGFB3: Involved in embryogenesis and cell differentiation. Homodimer; disulfide-linked. Interacts with ASPN. Belongs to the TGF-beta family.

Protein type: Cell development/differentiation; Ligand, receptor tyrosine kinase; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q24

Cellular Component: extracellular matrix; extracellular region; extracellular space; plasma membrane

Molecular Function: cytokine activity; identical protein binding; protein binding; punt binding; transforming growth factor beta binding

Biological Process: alveolus development; in utero embryonic development; intercellular junction assembly and maintenance; mammary gland development; negative regulation of cell proliferation; negative regulation of DNA replication; negative regulation of neuron apoptosis; palate development; platelet degranulation; positive regulation of apoptosis; positive regulation of bone mineralization; positive regulation of collagen biosynthetic process; positive regulation of DNA replication; positive regulation of filopodium formation; positive regulation of protein secretion; positive regulation of stress fiber formation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of cell proliferation; regulation of MAPKKK cascade; response to hypoxia; response to progesterone stimulus; salivary gland morphogenesis; transforming growth factor beta receptor signaling pathway; uterine wall breakdown

Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 1; Rienhoff Syndrome
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TGFB3 recombinant protein

 Reference Product  PubMed Publications
 TGFB2 recombinant protein  >625 publications with TGFB3 and TGFB2
 SMAD2 recombinant protein  >99 publications with TGFB3 and SMAD2
 SMAD3 recombinant protein  >75 publications with TGFB3 and SMAD3
 SMAD4 recombinant protein  >43 publications with TGFB3 and SMAD4
 TGFBR3 recombinant protein  >31 publications with TGFB3 and TGFBR3
 TGFBR2 recombinant protein  >18 publications with TGFB3 and TGFBR2
 TGFBR1 recombinant protein  >17 publications with TGFB3 and TGFBR1
 SMAD6 recombinant protein  >8 publications with TGFB3 and SMAD6
 FMOD recombinant protein  >6 publications with TGFB3 and FMOD
 ACVRL1 recombinant protein  >1 publications with TGFB3 and ACVRL1

Pathways associated with TGFB3 recombinant protein

 Products by Pathway  Pathway Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram

Diseases associated with TGFB3 recombinant protein

 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >212 publications with TGFB3 and Fibrosis
 Disease Models, Animal Antibodies  >124 publications with TGFB3 and Disease Models, Animal
 Cleft Palate Antibodies  >115 publications with TGFB3 and Cleft Palate
 Cardiovascular Diseases Antibodies  >98 publications with TGFB3 and Cardiovascular Diseases
 Inflammation Antibodies  >90 publications with TGFB3 and Inflammation
 Necrosis Antibodies  >71 publications with TGFB3 and Necrosis
 Heart Diseases Antibodies  >60 publications with TGFB3 and Heart Diseases
 Lung Diseases Antibodies  >44 publications with TGFB3 and Lung Diseases
 Breast Neoplasms Antibodies  >42 publications with TGFB3 and Breast Neoplasms
 Hypertrophy Antibodies  >40 publications with TGFB3 and Hypertrophy

Organs/Tissues associated with TGFB3 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >407 publications with TGFB3 and Bone
 Connective Tissue Antibodies  >288 publications with TGFB3 and Connective Tissue
 Embryonic Tissue Antibodies  >161 publications with TGFB3 and Embryonic Tissue
 Bone Marrow Antibodies  >147 publications with TGFB3 and Bone Marrow
 Mouth Antibodies  >131 publications with TGFB3 and Mouth
 Heart Antibodies  >88 publications with TGFB3 and Heart
 Lung Antibodies  >82 publications with TGFB3 and Lung
 Eye Antibodies  >77 publications with TGFB3 and Eye
 Brain Antibodies  >77 publications with TGFB3 and Brain
 Liver Antibodies  >58 publications with TGFB3 and Liver
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