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TBC1 Domain Family Member 23 (TBC1D23) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1411229

MBS1411229 is a recombinant protein targeting Tbc1d23. Also known as Recombinant Mouse TBC1 domain family member 23 (Tbc1d23). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1520 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TBC1 domain family member 23 (Tbc1d23), Recombinant Protein
Full Product Name
Recombinant Mouse TBC1 domain family member 23 (Tbc1d23)
Product Gene Name
Tbc1d23 recombinant protein
Product Synonym Gene Name
Tbc1d23
Sequence
MAEGEELLPL STSGGDSWEK DLEEALEAGG CDLETLRNII QGRPLPAELR AKVWKIALNV AGKGDSLASW DGILDLPEQN TIHKDCLEFI EQLSVPEEKA AELLLDIESV ITFYCKSRSV KYSTSLSWIH LLKPLICLQL PRSDLYNCFY AVMNKYIPRD CSLKGRPFHL FRLLIQYHEP ELCSFLDTKK ITPDSYALNW LGSLFAHYCS TEVTQAIWDG YLQQADPFFI YFLMLIILVN TKEVILAQES DSKEEVIRFL ESTPASLNLE DIEDLFSLAQ YYCSKTPASF RKDNHHLFGS TLLGIKDDEA DLSQALCLAV SVSEILQANQ LQGEGVRFFV VDCRPAEQYN AGHLATAFHL DSDLMLQNPS EFAQSVKSLL EAQKQSIESG SIAGGEHLCF MGSGREEEDM YMNMVLAHFL QKNKEYVSIA SGGFMALQQH LADINVEGPE SGYGHWIAST SGSRGSISSV DGESCNGSND RGMKSLVSKM TVALKTKSVT VREKVISFIE NSSTPVDRHV SSSDRVGKPY RGVKPVFSIG DEEEYDTDEI DSSSMSDDDR KEVVNIQTWI NKPDIKHHFP CKEVKESGHM FPSHLLVTAT HMYCLREILS RKGLAYIQSR QALNSVVKIT SKKKHPELIT FKYGNSSASG IEILAIERYL IPNAGDATRA IKQQIMKVLD ALES
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
23,074 Da
Sequence Positions
1-684, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q8K0F1
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Tbc1d23 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Tbc1d23. It may not necessarily be applicable to this product.

NCBI GI #
27754079
NCBI GeneID
67581
NCBI Accession #
NP_080530.2
UniProt Primary Accession #
Q8K0F1
UniProt Secondary Accession #
Q3TAW9; Q8VE48
UniProt Related Accession #
Q8K0F1
GenBank Nucleotide #
NM_026254.2
NCBI Official Full Name
TBC1 domain family member 23 isoform 2
NCBI Official Synonym Full Names
TBC1 domain family, member 23
NCBI Official Symbol
Tbc1d23
NCBI Official Synonym Symbols
W51689; AU015720; AU043671; AU043778; 4930451A13Rik; D030022P07Rik
UniProt Protein Name
TBC1 domain family member 23
Protein Family
TBC1 domain family
UniProt Gene Name
Tbc1d23
NCBI Protein Information
TBC1 domain family member 23

UniProt Comments for Tbc1d23

Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197). Plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes which are essential for axonal and dendritic growth (PubMed:28823707). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (PubMed:22312129).
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Research Articles on Tbc1d23

1. Homozygous Truncating Variants in TBC1D23 gene are associated with Pontocerebellar Hypoplasia and Alter Cortical Development.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with Tbc1d23 recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >3 publications with Tbc1d23 and Inflammation

Organs/Tissues associated with Tbc1d23 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1 publications with Tbc1d23 and Brain
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