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E3 Ubiquitin-Protein Ligase RNF135 (RNF135) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1411302

This protein contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in… More details

$1185 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
E3 ubiquitin-protein ligase RNF135 (RNF135), Recombinant Protein
Full Product Name
Recombinant Human E3 ubiquitin-protein ligase RNF135 (RNF135)
Product Gene Name
RNF135 recombinant protein
Product Synonym Gene Name
RNF135
Sequence
MAGLGLGSAV PVWLAEDDLG CIICQGLLDW PATLPCGHSF CRHCLEALWG ARDARRWACP TCRQGAAQQP HLRKNTLLQD LADKYRRAAR EIQAGSDPAH CPCPGSSSLS SAAARPRRRP ELQRVAVEKS ITEVAQELTE LVEHLVDIVR SLQNQRPLSE SGPDNELSIL GKAFSSGVDL SMASPKLVTS DTAAGKIRDI LHDLEEIQEK LQESVTWKEA PEAQMQGELL EAPSSSSCPL PDQSHPALRR ASRFAQWAIH PTFNLKSLSC SLEVSKDSRT VTVSHRPQPY RWSCERFSTS QVLCSQALSS GKHYWEVDTR NCSHWAVGVA SWEMSRDQVL GRTMDSCCVE WKGTSQLSAW HMVKETVLGS DRPGVVGIWL NLEEGKLAFY SVDNQEKLLY ECTISASSPL YPAFWLYGLH PGNYLIIKQV KV
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
30,989 Da
Sequence Positions
1-432, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
611358
3D Structure
ModBase 3D Structure for Q8IUD6
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of RNF135 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RNF135 purchase

MBS1411302 is a recombinant protein targeting RNF135. Also known as Recombinant Human E3 ubiquitin-protein ligase RNF135 (RNF135). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for RNF135. It may not necessarily be applicable to this product.

NCBI GI #
297139721
NCBI GeneID
84282
NCBI Accession #
NP_001171921.1
UniProt Primary Accession #
Q8IUD6
UniProt Secondary Accession #
Q9BSE9; A0AVM5; B2R7G9; B6ZLM5; F5GX60
UniProt Related Accession #
Q8IUD6
GenBank Nucleotide #
NM_001184992.1
NCBI Official Full Name
E3 ubiquitin-protein ligase RNF135 isoform 3
NCBI Official Synonym Full Names
ring finger protein 135
NCBI Official Symbol
RNF135
NCBI Official Synonym Symbols
L13; MMFD; REUL; Riplet
UniProt Protein Name
E3 ubiquitin-protein ligase RNF135
UniProt Synonym Protein Names
RIG-I E3 ubiquitin ligase; REUL; RING finger protein 135; RING-type E3 ubiquitin transferase RNF135Curated; Riplet
Protein Family
E3 ubiquitin-protein ligase
UniProt Gene Name
RNF135
UniProt Synonym Gene Names
REUL
NCBI Protein Information
E3 ubiquitin-protein ligase RNF135

NCBI Summary for RNF135

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
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UniProt Comments for RNF135

Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses. Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta production.

Research Articles on RNF135

1. In-depth analysis of population-differentiated regions indicated that the coding gene, RNF135, represented a trans-regulation hotspot via cis-regulation by the population-specific variants in the region of selective sweep.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with RNF135 recombinant protein

 Reference Product  PubMed Publications
 TRIM25 recombinant protein  >2 publications with RNF135 and TRIM25
 DDX58 recombinant protein  >2 publications with RNF135 and DDX58
 MAVS recombinant protein  >1 publications with RNF135 and MAVS

Pathways associated with RNF135 recombinant protein

 Products by Pathway  Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 NF-kB Activation Through FADD/RIP-1 Pathway Mediated By Caspase-8 And -10 antibodies  NF-kB Activation Through FADD/RIP-1 Pathway Mediated By Caspase-8 And -10 Diagram
 Negative Regulators Of RIG-I/MDA5 Signaling Pathway antibodies  Negative Regulators Of RIG-I/MDA5 Signaling Pathway Diagram
 RIG-I/MDA5 Mediated Induction Of IFN-alpha/beta Pathways antibodies  RIG-I/MDA5 Mediated Induction Of IFN-alpha/beta Pathways Diagram
 TRAF3-dependent IRF Activation Pathway antibodies  TRAF3-dependent IRF Activation Pathway Diagram
 TRAF6 Mediated IRF7 Activation Pathway antibodies  TRAF6 Mediated IRF7 Activation Pathway Diagram
 TRAF6 Mediated NF-kB Activation Pathway antibodies  TRAF6 Mediated NF-kB Activation Pathway Diagram

Diseases associated with RNF135 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3 publications with RNF135 and Neoplasms
 Genetic Predisposition to Disease Antibodies  >1 publications with RNF135 and Genetic Predisposition to Disease
 Craniofacial Abnormalities Antibodies  >1 publications with RNF135 and Craniofacial Abnormalities
 Mental Disorders Antibodies  >1 publications with RNF135 and Mental Disorders
 Neurobehavioral Manifestations Antibodies  >1 publications with RNF135 and Neurobehavioral Manifestations
 Learning Disorders Antibodies  >1 publications with RNF135 and Learning Disorders
 Growth Disorders Antibodies  >1 publications with RNF135 and Growth Disorders

Organs/Tissues associated with RNF135 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1 publications with RNF135 and Brain
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