Human HMGN3 Recombinant Protein – Cat# MBS141166

High Mobility Group Nucleosomal Binding Domain 3 (HMGN3) Human Recombinant Protein

Name: HMGN3 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS141166
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS141166

Introduction: High Mobility Group Nucleosomal Binding Domain 3 (HMGN3), binds thyroid hormone receptor beta, however it occurs only in the presence of thyroid hormone. Thyroid hormone receptors are hormone-dependent transcription factors which regulate… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

High Mobility Group Nucleosomal Binding Domain 3 (HMGN3), Recombinant Protein

Full Product Name

Recombinant Human High Mobility Group Nucleosomal Binding Domain 3

Product Gene Name

HMGN3 recombinant protein

Product Synonym Names

HMGN3 Human; High Mobility Group Nucleosomal Binding Domain 3 Human Recombinant; High Mobility Group Nucleosomal Binding Domain 3; TRIP7; TR-Interacting Protein 7; High Mobility Group Nucleosome-Binding Domain-Containing Protein 3; Thyroid Hormone Receptor Interacting Protein 7; Thyroid Receptor-Interacting Protein 7; Thyroid Hormone Receptor Interactor 7; PNAS-24; PNAS-25; TRIP-7; High mobility group nucleosome-binding domain-containing protein 3

Sequence

MGSSHHH HHH SSGLVPRGSH MGSMPK RKSP ENTEGKDGSK VTKQEPTRRS ARLSAKPAPP KPEPKPRKTS AKKEPGAKIS RGAKGKKEEK QEAGKEGTEN

Host

E Coli

Form/Format

HMGN3 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH7.0) and 10% glycerol.
Sterile filtered colorless solution.

Purity/Purification

Greater than 95% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Molecular Weight

8,378 Da

OMIM

604502

3D Structure

ModBase 3D Structure for Q15651

Product Categories/Family for HMGN3 recombinant protein

Recombinant & Natural Proteins

Other Notes

Small volumes of HMGN3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HMGN3 purchase

MBS141166 is a recombinant protein targeting HMGN3. Also known as Recombinant Human High Mobility Group Nucleosomal Binding Domain 3. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for HMGN3. It may not necessarily be applicable to this product.

NCBI GI #

318067959

NCBI GeneID

9324

NCBI Accession #

NP_001188291.1

UniProt Primary Accession #

Q15651

UniProt Secondary Accession #

Q5HYD3; Q7RTT0; Q969M5; Q9BZT7; B2RD37

UniProt Related Accession #

Q15651

GenBank Nucleotide #

NM_001201362.1

NCBI Official Full Name

high mobility group nucleosome-binding domain-containing protein 3 isoform c

NCBI Official Synonym Full Names

high mobility group nucleosomal binding domain 3

NCBI Official Symbol

HMGN3

NCBI Official Synonym Symbols

TRIP7; PNAS-24; PNAS-25

UniProt Protein Name

High mobility group nucleosome-binding domain-containing protein 3

UniProt Synonym Protein Names

Thyroid receptor-interacting protein 7; TR-interacting protein 7; TRIP-7

Protein Family

High mobility group nucleosome-binding domain-containing protein

UniProt Gene Name

HMGN3

UniProt Synonym Gene Names

TRIP7; TR-interacting protein 7; TRIP-7

UniProt Entry Name

HMGN3_HUMAN

NCBI Protein Information

high mobility group nucleosome-binding domain-containing protein 3

UniProt Comments for HMGN3

HMGN3: Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function. Belongs to the HMGN family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 6q14.1

Cellular Component: cytoplasm; nucleoplasm

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with HMGN3 recombinant protein

Disease Name	Pubmed Publications
Adenocarcinoma Antibodies	>1 publications with HMGN3 and Adenocarcinoma
Liver Neoplasms Antibodies	>1 publications with HMGN3 and Liver Neoplasms
Carcinoma, Hepatocellular Antibodies	>1 publications with HMGN3 and Carcinoma, Hepatocellular
Disease Models, Animal Antibodies	>1 publications with HMGN3 and Disease Models, Animal
Liver Diseases Antibodies	>1 publications with HMGN3 and Liver Diseases

Organs/Tissues associated with HMGN3 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>8 publications with HMGN3 and Brain
Blood Antibodies	>2 publications with HMGN3 and Blood
Eye Antibodies	>2 publications with HMGN3 and Eye
Pancreas Antibodies	>2 publications with HMGN3 and Pancreas
Thyroid Antibodies	>2 publications with HMGN3 and Thyroid
Muscle Antibodies	>1 publications with HMGN3 and Muscle
Liver Antibodies	>1 publications with HMGN3 and Liver
Ovary Antibodies	>1 publications with HMGN3 and Ovary
Uterus Antibodies	>1 publications with HMGN3 and Uterus
Skin Antibodies	>1 publications with HMGN3 and Skin