Mouse Anti-MAPKSP1 Monoclonal Antibody – Cat# MBS141205

MAPK Scaffold Protein 1 (MAPKSP1) Antibody – Mouse Monoclonal

Name: MAPKSP1 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS141205
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS141205

MAPKSP1 is a scaffold protein which operates in the extracellular signal-regulated kinase (ERK) cascade. MAPKSP1 protein is restricted to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MAPK Scaffold Protein 1 (MAPKSP1), Monoclonal Antibody

Full Product Name

Mouse Anti Human MAPK Scaffold Protein 1

Product Gene Name

anti-MAPKSP1 antibody

Product Synonym Names

MAPK Scaffold Protein 1, Mouse Anti Human; MAPBP; MP1; MAPK Scaffold Protein 1; Interacting Protein 1; MEK binding partner 1; Mitogen-Activated Protein Kinase kinase 1; MAPKSP1 antibody

Clonality

Monoclonal

Isotype

IgG2b heavy chain and k light chain.

Clone Number

PAT1F10AT.

Host

Mouse

Species Reactivity

Human

Form/Format

Sterile filtered colorless solution.
1mg/ml containing PBS, pH-7.4, 10% Glycerol and 0.02% Sodium Azide.

Purity/Purification

Purified from mouse ascitic fluids by Protein-A affinity chromatography.

Preparation and Storage

For 12 months store at -20 degree C. For 1 month store at 4 degree C.
Prevent freeze thaw cycles.

Molecular Weight

12,941 Da

Immunogen

Anti-human MAPKSP1 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human MAPKSP1 protein 1-124 amino acids purified from E. coli.

Product Categories/Family for anti-MAPKSP1 antibody

Monoclonal/Polyclonal Antibodies

Application Notes for anti-MAPKSP1 antibody

The antibody has been tested by ELISA, Western blot analysis, Flow cytometry and ICC/IF to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.

Other Notes

Small volumes of anti-MAPKSP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MAPKSP1 purchase

MBS141205 is an antibody targeting MAPKSP1. Also known as Mouse Anti Human MAPK Scaffold Protein 1. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for MAPKSP1. It may not necessarily be applicable to this product.

NCBI GI #

20072808

NCBI GeneID

8649

NCBI Accession #

AAH26245.1

UniProt Secondary Accession #

Q9H364; B2R4A1; J3KMX4

UniProt Related Accession #

Q9UHA4

NCBI Official Full Name

MAPK scaffold protein 1

NCBI Official Synonym Full Names

late endosomal/lysosomal adaptor, MAPK and MTOR activator 3

NCBI Official Symbol

LAMTOR3

NCBI Official Synonym Symbols

MP1; MAPBP; MAPKSP1; PRO0633; MAP2K1IP1; Ragulator3

UniProt Protein Name

Ragulator complex protein LAMTOR3

UniProt Synonym Protein Names

Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3; MEK-binding partner 1; Mp1; Mitogen-activated protein kinase kinase 1-interacting protein 1; Mitogen-activated protein kinase scaffold protein 1

UniProt Gene Name

LAMTOR3

UniProt Synonym Gene Names

MAP2K1IP1; MAPKSP1; Mp1

NCBI Protein Information

ragulator complex protein LAMTOR3

NCBI Summary for MAPKSP1

This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011]

UniProt Comments for MAPKSP1

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.

Research Articles on MAPKSP1

1. Studied role of MEK partner-1 (LAMTOR3) in driving MEK/ERK pathway in EGFRviii-expressing glioma cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MAPKSP1 antibody

Reference Product	PubMed Publications
MAPK1 antibody	>3 publications with MAPKSP1 and MAPK1
MAPK3 antibody	>2 publications with MAPKSP1 and MAPK3
MAP2K1 antibody	>2 publications with MAPKSP1 and MAP2K1
C11orf59 antibody	>1 publications with MAPKSP1 and C11orf59
ROBLD3 antibody	>1 publications with MAPKSP1 and ROBLD3

Pathways associated with anti-MAPKSP1 antibody

Products by Pathway	Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram

Organs/Tissues associated with anti-MAPKSP1 antibody

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>2 publications with MAPKSP1 and Skin
Blood Antibodies	>1 publications with MAPKSP1 and Blood
Stomach Antibodies	>1 publications with MAPKSP1 and Stomach
Muscle Antibodies	>1 publications with MAPKSP1 and Muscle
Embryonic Tissue Antibodies	>1 publications with MAPKSP1 and Embryonic Tissue