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P-Selectin Glycoprotein Ligand 1 (SELPLG) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1412382

SELPLG is the high affinity counter-receptor for P-selectin on myeloid cells and stimulated T lymphocytes. As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin. The organization of the… More details

$1445 / 0.5 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
P-selectin glycoprotein ligand 1 (SELPLG), Recombinant Protein
Full Product Name
Recombinant Human P-selectin glycoprotein ligand 1 (SELPLG), partial
Product Gene Name
SELPLG recombinant protein
Product Synonym Gene Name
SELPLG
Sequence
LQL WDTWADEAEK ALGPLLARDR RQATEYEYLD YDFLPETEPP EMLRNSTDTT PLTGPGTPES TTVEPAARRS TGLDAGGAVT ELTTELANMG NLSTDSAAME IQTTQPAATE AQTTQPVPTE AQTTPLAATE AQTTRLTATE AQTTPLAATE AQTTPPAATE AQTTQPTGLE AQTTAPAAME AQTTAPAAME AQTTPPAAME AQTTQTTAME AQTTAPEATE AQTTQPTATE AQTTPLAAME ALSTEPSATE ALSMEPTTKR GLFIPFSVSS VTHKGIPMAA SNLSVNYPVG APDHISVKQC
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
44,648 Da
Sequence Positions
18-320
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
600738
3D Structure
ModBase 3D Structure for Q14242
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of SELPLG recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SELPLG purchase

MBS1412382 is a recombinant protein targeting SELPLG. Also known as Recombinant Human P-selectin glycoprotein ligand 1 (SELPLG), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for SELPLG. It may not necessarily be applicable to this product.

NCBI GI #
331284238
NCBI GeneID
6404
NCBI Accession #
NP_001193538.1
UniProt Primary Accession #
Q14242
UniProt Secondary Accession #
Q12775; Q6GTW7; Q8N7J7; A8K2Y0; B4DQC3; B7Z5C7; J3KMX6
UniProt Related Accession #
Q14242
GenBank Nucleotide #
NM_001206609.1
NCBI Official Full Name
P-selectin glycoprotein ligand 1 isoform 1
NCBI Official Synonym Full Names
selectin P ligand
NCBI Official Symbol
SELPLG
NCBI Official Synonym Symbols
CLA; CD162; PSGL1; PSGL-1
UniProt Protein Name
P-selectin glycoprotein ligand 1
UniProt Synonym Protein Names
Selectin P ligand; CD_antigen: CD162
Protein Family
P-selectin glycoprotein ligand
UniProt Gene Name
SELPLG
UniProt Synonym Gene Names
PSGL-1
NCBI Protein Information
P-selectin glycoprotein ligand 1

NCBI Summary for SELPLG

This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]
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UniProt Comments for SELPLG

A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.

Research Articles on SELPLG

1. Studies indicate that P-selectin glycoprotein ligand-1 (PSGL-1) PSGL-1 can negatively regulate T cell function.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SELPLG recombinant protein

 Reference Product  PubMed Publications
 SELP recombinant protein  >5 publications with SELPLG and SELP
 SYK recombinant protein  >1 publications with SELPLG and SYK

Pathways associated with SELPLG recombinant protein

 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Staphylococcus Aureus Infection Pathway antibodies  Staphylococcus Aureus Infection Pathway Diagram
 Staphylococcus Aureus Infection Pathway antibodies  Staphylococcus Aureus Infection Pathway Diagram
 Amb2 Integrin Signaling Pathway antibodies  Amb2 Integrin Signaling Pathway Diagram

Diseases associated with SELPLG recombinant protein

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >6 publications with SELPLG and Cardiovascular Diseases
 Atherosclerosis Antibodies  >4 publications with SELPLG and Atherosclerosis
 Neoplasms Antibodies  >2 publications with SELPLG and Neoplasms
 Congenital Abnormalities Antibodies  >1 publications with SELPLG and Congenital Abnormalities
 Hypertension Antibodies  >1 publications with SELPLG and Hypertension
 Drug Toxicity Antibodies  >1 publications with SELPLG and Drug Toxicity
 Diabetes Mellitus, Type 2 Antibodies  >1 publications with SELPLG and Diabetes Mellitus, Type 2
 Myocardial Infarction Antibodies  >1 publications with SELPLG and Myocardial Infarction
 Inflammation Antibodies  >1 publications with SELPLG and Inflammation
 Necrosis Antibodies  >1 publications with SELPLG and Necrosis

Organs/Tissues associated with SELPLG recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >10 publications with SELPLG and Blood
 Bone Antibodies  >2 publications with SELPLG and Bone
 Bone Marrow Antibodies  >2 publications with SELPLG and Bone Marrow
 Placenta Antibodies  >2 publications with SELPLG and Placenta
 Embryonic Tissue Antibodies  >2 publications with SELPLG and Embryonic Tissue
 Heart Antibodies  >1 publications with SELPLG and Heart
 Lung Antibodies  >1 publications with SELPLG and Lung
 Spleen Antibodies  >1 publications with SELPLG and Spleen
 Brain Antibodies  >1 publications with SELPLG and Brain
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