Rat MRE11A Recombinant Protein – Cat# MBS1412512

Double-Strand Break Repair Protein MRE11A (MRE11A) Rat Recombinant Protein

Name: MRE11A Recombinant Protein; Rat; MyBioSource
Brand: MyBioSource
SKU: MBS1412512
Price: 1550 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1412512

This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3 to 5 exonuclease activity and endonuclease activity. The protein forms a complex with the… More details

$1550 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Double-strand break repair protein MRE11A (Mre11a), Recombinant Protein

Full Product Name

Recombinant Rat Double-strand break repair protein MRE11A (Mre11a)

Product Gene Name

Mre11a recombinant protein

Product Synonym Gene Name

Mre11a

Sequence

SPTDPLDDED TFKILVATDI HLGFMEKDAV RGNDTFVTFD EILRLALENE VDFILLGGDL FHENKPSRKT LHSCLELLRK YCMGDRPVQF EIISDQSVNF GFSKFPWVNY RDGNLNISIP VFSIHGNHDD PTGADALCAL DVLSCAGFVN HFGRSMSVEK VDISPVLLQK GSTKLALYGL GSIPDERLYR MFVNKKVTML RPKEDENSWF NLFVIHQNRS KHGSTNFIPE QFLDDFIDLV IWGHEHECKI GPTRNEQQLF YVSQPGSSVV TALSPGETVK KHVGLLRVKG RKMNMQKLPL RTVRQFFMED VVLANHPSLF NPDNPKVTQA IQSFCLEKIE EMLDSAERER LGNPQQPEKP LIRLRVDYSG GFEPFNVLRF SQKFVDRVAN PKDVIHFFRH REQKGKTGEE INFGKLIIKP ASEGTTLRVE DLVKQYFQTA EKNVQLSLLT ERGMGEAVQE FVDKEEKDAI EELVKYQLEK TQRFLKERHI DALEDKIDEE VRRFRESRQR NTNEEDDEVR EAMSRARALR SQSENAASAF SADDLSFDIT EQTADDSDDS QSAVPSRGRG RGRGRRGGRG QSTAPRGGSQ RGRDTGLGIS TRGRSSKATA STSRNMSIID AFRSTRQQPS RNVATKNYSE TIEVDESDDD DSFPTSSRAD QRWSGTAPSK RMSQSQTAKG VDFESDEDDD DDPFMSGSCP RRNRR

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

80,122 Da

Sequence Positions

2-706, full length protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for Q9JIM0

Species

Rat

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Mre11a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Mre11a purchase

MBS1412512 is a recombinant protein targeting Mre11a. Also known as Recombinant Rat Double-strand break repair protein MRE11A (Mre11a). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Mre11a. It may not necessarily be applicable to this product.

NCBI GI #

11560107

NCBI GeneID

64046

NCBI Accession #

NP_071615.1

UniProt Primary Accession #

Q9JIM0

UniProt Related Accession #

Q9JIM0

GenBank Nucleotide #

NM_022279.1

NCBI Official Full Name

double-strand break repair protein MRE11

NCBI Official Synonym Full Names

MRE11 homolog A, double strand break repair nuclease

NCBI Official Symbol

Mre11a

NCBI Official Synonym Symbols

Mre11

UniProt Protein Name

Double-strand break repair protein MRE11

UniProt Synonym Protein Names

Double-strand break repair protein MRE11A; Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog A

Protein Family

Double-strand break repair protein

UniProt Gene Name

Mre11

UniProt Synonym Gene Names

Mre11a; MRE11 homolog 1; MRE11 homolog A

NCBI Protein Information

double-strand break repair protein MRE11; double-strand break repair protein MRE11A

NCBI Summary for Mre11a

may play a role in regulation of cardiomyocyte proliferation [RGD, Feb 2006]

UniProt Comments for Mre11a

Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Mre11a recombinant protein

Reference Product	PubMed Publications
Rad50 recombinant protein	>300 publications with Mre11a and Rad50
Nbn recombinant protein	>213 publications with Mre11a and Nbn
Atm recombinant protein	>184 publications with Mre11a and Atm
Brca1 recombinant protein	>55 publications with Mre11a and Brca1
Mdc1 recombinant protein	>27 publications with Mre11a and Mdc1
Rbbp8 recombinant protein	>21 publications with Mre11a and Rbbp8
Exo1 recombinant protein	>8 publications with Mre11a and Exo1
Fancd2 recombinant protein	>8 publications with Mre11a and Fancd2
Prmt1 recombinant protein	>6 publications with Mre11a and Prmt1
Xrcc6 recombinant protein	>2 publications with Mre11a and Xrcc6

Pathways associated with Mre11a recombinant protein

Products by Pathway	Pathway Diagram
Assembly Of The RAD50-MRE11-NBS1 Complex At DNA Double-strand Breaks Pathway antibodies	Assembly Of The RAD50-MRE11-NBS1 Complex At DNA Double-strand Breaks Pathway Diagram
DNA Repair Pathway antibodies	DNA Repair Pathway Diagram
Double-Strand Break Repair Pathway antibodies	Double-Strand Break Repair Pathway Diagram
Homologous Recombination Repair Pathway antibodies	Homologous Recombination Repair Pathway Diagram
Homologous Recombination Pathway antibodies	Homologous Recombination Pathway Diagram
Homologous Recombination Pathway antibodies	Homologous Recombination Pathway Diagram
Homologous Recombination Repair Of Replication-independent Double-strand Breaks Pathway antibodies	Homologous Recombination Repair Of Replication-independent Double-strand Breaks Pathway Diagram
MRN Complex Relocalizes To Nuclear Foci Pathway antibodies	MRN Complex Relocalizes To Nuclear Foci Pathway Diagram
Non-homologous End-joining Pathway antibodies	Non-homologous End-joining Pathway Diagram
Recruitment Of Repair And Signaling Proteins To Double-strand Breaks Pathway antibodies	Recruitment Of Repair And Signaling Proteins To Double-strand Breaks Pathway Diagram

Diseases associated with Mre11a recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>90 publications with Mre11a and Neoplasms
Neurologic Manifestations Antibodies	>37 publications with Mre11a and Neurologic Manifestations
ATAXIA-TELANGIECTASIA-LIKE DISORDER Antibodies	>28 publications with Mre11a and ATAXIA-TELANGIECTASIA-LIKE DISORDER
Breast Neoplasms Antibodies	>21 publications with Mre11a and Breast Neoplasms
Colorectal Neoplasms Antibodies	>19 publications with Mre11a and Colorectal Neoplasms
Leukemia Antibodies	>15 publications with Mre11a and Leukemia
Lymphoma Antibodies	>11 publications with Mre11a and Lymphoma
Lung Neoplasms Antibodies	>8 publications with Mre11a and Lung Neoplasms
Cell Transformation, Neoplastic Antibodies	>8 publications with Mre11a and Cell Transformation, Neoplastic
Ovarian Neoplasms Antibodies	>8 publications with Mre11a and Ovarian Neoplasms

Organs/Tissues associated with Mre11a recombinant protein

Organ/Tissue Name	Pubmed Publications
Prostate Antibodies	>4 publications with Mre11a and Prostate