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Lysine Methyltransferase 5a (KMT5A) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS141255

Description: KMT5A produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 165 amino acids (195-352 a.a.) and having a molecular mass of 18.9kDa (Migrates at 18-28 kDa on SDS-PAGE under reducing conditions). KMT5A is expressed… More details

$250 / 0.002 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Lysine Methyltransferase 5A (KMT5A), Recombinant Protein
Full Product Name
Recombinant Human Lysine Methyltransferase 5A
Product Gene Name
KMT5A recombinant protein
Product Synonym Names
Lysine Methyltransferase 5A Human Recombinant; KMT5A; PR-Set7; SET07; SET8; SETD8; H4-K20-HMTase KMT5A; KMT5A Human
Sequence
MKAELQSEER KRIDELIESG KEEGMKIDLI DGKGRGVIAT KQFSRGDFVV EYHGDLIEIT DAKKREALYA QDPSTGCYMY YFQYLSKTYC VDATRETNRL GRLINHSKCG NCQTKLHDID GVPHLILIAS RDIAAGEELL YDYGDRSKAS IEAHPWLKHH HHHHH.
Host
Sf9, Baculovirus cells
Form/Format
Sterile filtered colorless solution.
Protein solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 5mM DTT, 0.2M NaCl, 1mM EDTA and 50% glycerol.
Purity/Purification
Greater than 85.0% as determined by SDS-PAGE.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Molecular Weight
39,223 Da
3D Structure
ModBase 3D Structure for Q9NQR1

Product Categories/Family for KMT5A recombinant protein

Enzymes

Other Notes

Small volumes of KMT5A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KMT5A purchase

MBS141255 is a recombinant protein targeting KMT5A. Also known as Recombinant Human Lysine Methyltransferase 5A. Host: Sf9, Baculovirus cells.

Additional Details

NCBI/Uniprot data below describe general gene information for KMT5A. It may not necessarily be applicable to this product.

NCBI GI #
25091219
NCBI GeneID
387893
NCBI Accession #
Q9NQR1.3
UniProt Primary Accession #
Q9NQR1
UniProt Secondary Accession #
Q86W83; Q8TD09; A8K9D0
UniProt Related Accession #
Q9NQR1
NCBI Official Full Name
N-lysine methyltransferase KMT5A
NCBI Official Synonym Full Names
lysine methyltransferase 5A
NCBI Official Symbol
KMT5A
NCBI Official Synonym Symbols
SET8; SET07; SETD8; PR-Set7
UniProt Protein Name
N-lysine methyltransferase KMT5A
UniProt Synonym Protein Names
H4-K20-HMTase KMT5A; Histone-lysine N-methyltransferase KMT5A (EC:2.1.1.43); Lysine N-methyltransferase 5A; Lysine-specific methylase 5A
Protein Family
N-lysine methyltransferase
UniProt Gene Name
KMT5A
UniProt Synonym Gene Names
PRSET7; SET07; SET8; SETD8; PR-Set7; PR/SET07
NCBI Protein Information
N-lysine methyltransferase KMT5A

NCBI Summary for KMT5A

The protein encoded by this gene is a protein-lysine N-methyltransferase that can monomethylate Lys-20 of histone H4 to effect transcriptional repression of some genes. The encoded protein is required for cell proliferation and plays a role in chromatin condensation. [provided by RefSeq, May 2016]

UniProt Comments for KMT5A

Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.
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Research Articles on KMT5A

1. that oncogenic SETD8 was regulated by miR-382 and involved glioma progression

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with KMT5A recombinant protein

 Reference Product  PubMed Publications
 PCNA recombinant protein  >11 publications with KMT5A and PCNA
 DTL recombinant protein  >8 publications with KMT5A and DTL
 TP53 recombinant protein  >7 publications with KMT5A and TP53

Pathways associated with KMT5A recombinant protein

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Condensation Of Prophase Chromosomes Pathway antibodies  Condensation Of Prophase Chromosomes Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Prophase Pathway antibodies  Mitotic Prophase Pathway Diagram
 P53 Pathway antibodies  P53 Pathway Diagram

Diseases associated with KMT5A recombinant protein

 Disease Name  Pubmed Publications
 Skin Diseases Antibodies  >5 publications with KMT5A and Skin Diseases
 Fetal Growth Retardation Antibodies  >1 publications with KMT5A and Fetal Growth Retardation
 Liver Neoplasms Antibodies  >1 publications with KMT5A and Liver Neoplasms
 Liver Diseases Antibodies  >1 publications with KMT5A and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with KMT5A and Carcinoma, Hepatocellular

Organs/Tissues associated with KMT5A recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with KMT5A and Blood
 Skin Antibodies  >4 publications with KMT5A and Skin
 Liver Antibodies  >3 publications with KMT5A and Liver
 Brain Antibodies  >3 publications with KMT5A and Brain
 Lung Antibodies  >3 publications with KMT5A and Lung
 Kidney Antibodies  >2 publications with KMT5A and Kidney
 Intestine Antibodies  >2 publications with KMT5A and Intestine
 Nerve Antibodies  >1 publications with KMT5A and Nerve
 Embryonic Tissue Antibodies  >1 publications with KMT5A and Embryonic Tissue
 Prostate Antibodies  >1 publications with KMT5A and Prostate
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