Human CD47 Recombinant Protein – Cat# MBS141263

CD47 Human Recombinant Protein

Name: CD47 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS141263
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS141263

Description: CD47 Human Recombinant produced in Sf9 Insect cell is a single, non-glycosylated polypeptide chain containing 362 amino acids (19-141aa.a) and having a molecular mass of 40.9kDa (Migrates at 40-57kDa on SDS-PAGE under reducing conditions). CD47… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD47, Recombinant Protein

Full Product Name

Recombinant Human CD47, IgG-His Tag

Product Gene Name

CD47 recombinant protein

Product Synonym Names

CD47 Human Recombinant, IgG-His Tag; CD47 Molecule; Antigenic Surface Determinant Protein OA3; CD47 Antigen (Rh-Related Antigen; Integrin-Associated Signal Transducer); Antigen Identified by Monoclonal; Antibody 1D8; Integrin Associated Protein; Integrin-Associated Protein; Rh-Related; Antigen; CD47 Glycoprotein; MER6; IAP; Integrin-Associated Signal Transducer; Leukocyte Surface Antigen CD47; CD47 Antigen; Protein MER6; OA3; CD47 Human, IgG-His

Sequence

QLLFNKTKSV EFTFCNDTVV IPCFVTNMEA QNTTEVYVKW KFKGRDIYTF DGALNKSTVP TDFSSAKIEV SQLLKGDASL KMDKSDAVSH TGNYTCEVTE LTREGETIIE LKYRVVSWFS PNELEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGKHHHH HH.

Host

Sf9, Insect cells

Form/Format

Sterile filtered colorless solution.
Protein solution (0.5mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol.

Purity/Purification

Greater than 95.0% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.

Molecular Weight

31,743 Da

3D Structure

ModBase 3D Structure for Q08722

Product Categories/Family for CD47 recombinant protein

Recombinant & Natural Proteins

Other Notes

Small volumes of CD47 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD47 purchase

MBS141263 is a recombinant protein targeting CD47. Also known as Recombinant Human CD47, IgG-His Tag. Host: Sf9, Insect cells.

Additional Details

NCBI/Uniprot data below describe general gene information for CD47. It may not necessarily be applicable to this product.

NCBI GI #

1171879

NCBI GeneID

961

NCBI Accession #

Q08722.1

UniProt Primary Accession #

Q08722

UniProt Secondary Accession #

Q53Y71; Q96A60; A8K198; D3DN59

UniProt Related Accession #

Q08722

NCBI Official Full Name

Leukocyte surface antigen CD47

NCBI Official Synonym Full Names

CD47 molecule

NCBI Official Symbol

CD47

NCBI Official Synonym Symbols

IAP; OA3; MER6

UniProt Protein Name

Leukocyte surface antigen CD47

UniProt Synonym Protein Names

Antigenic surface determinant protein OA3; Integrin-associated protein; IAP; Protein MER6; CD_antigen: CD47

Protein Family

Leukocyte surface antigen

UniProt Gene Name

CD47

UniProt Synonym Gene Names

MER6; IAP

NCBI Protein Information

leukocyte surface antigen CD47

NCBI Summary for CD47

This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]

UniProt Comments for CD47

Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.

Research Articles on CD47

1. High CD47 expression is associated with the increase in the ability of surviving breast cancer cells to evade innate and adaptive immunity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CD47 recombinant protein

Reference Product	PubMed Publications
THBS1 recombinant protein	>141 publications with CD47 and THBS1
SIRPA recombinant protein	>72 publications with CD47 and SIRPA
RHAG recombinant protein	>22 publications with CD47 and RHAG
PTPN11 recombinant protein	>7 publications with CD47 and PTPN11
SIRPB1 recombinant protein	>5 publications with CD47 and SIRPB1
SIRPG recombinant protein	>3 publications with CD47 and SIRPG
THBS2 recombinant protein	>1 publications with CD47 and THBS2
ITGB3 recombinant protein	>1 publications with CD47 and ITGB3
ITGAV recombinant protein	>1 publications with CD47 and ITGAV

Pathways associated with CD47 recombinant protein

Products by Pathway	Pathway Diagram
Cell Surface Interactions At The Vascular Wall Pathway antibodies	Cell Surface Interactions At The Vascular Wall Pathway Diagram
Cell-Cell Communication Pathway antibodies	Cell-Cell Communication Pathway Diagram
ECM-receptor Interaction Pathway antibodies	ECM-receptor Interaction Pathway Diagram
ECM-receptor Interaction Pathway antibodies	ECM-receptor Interaction Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Integrin Cell Surface Interactions Pathway antibodies	Integrin Cell Surface Interactions Pathway Diagram
Integrins In Angiogenesis Pathway antibodies	Integrins In Angiogenesis Pathway Diagram
Signal Regulatory Protein (SIRP) Family Interactions Pathway antibodies	Signal Regulatory Protein (SIRP) Family Interactions Pathway Diagram
Spinal Cord Injury Pathway antibodies	Spinal Cord Injury Pathway Diagram

Diseases associated with CD47 recombinant protein

Disease Name	Pubmed Publications
Immune System Diseases Antibodies	>84 publications with CD47 and Immune System Diseases
Inflammation Antibodies	>81 publications with CD47 and Inflammation
Disease Models, Animal Antibodies	>46 publications with CD47 and Disease Models, Animal
Anemia Antibodies	>43 publications with CD47 and Anemia
Necrosis Antibodies	>42 publications with CD47 and Necrosis
Nervous System Diseases Antibodies	>33 publications with CD47 and Nervous System Diseases
Brain Diseases Antibodies	>28 publications with CD47 and Brain Diseases
Neoplasms, Experimental Antibodies	>23 publications with CD47 and Neoplasms, Experimental
Respiratory Tract Diseases Antibodies	>14 publications with CD47 and Respiratory Tract Diseases
Breast Neoplasms Antibodies	>10 publications with CD47 and Breast Neoplasms

Organs/Tissues associated with CD47 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>434 publications with CD47 and Blood
Vascular Antibodies	>105 publications with CD47 and Vascular
Bone Antibodies	>75 publications with CD47 and Bone
Bone Marrow Antibodies	>62 publications with CD47 and Bone Marrow
Brain Antibodies	>57 publications with CD47 and Brain
Muscle Antibodies	>54 publications with CD47 and Muscle
Lung Antibodies	>28 publications with CD47 and Lung
Liver Antibodies	>28 publications with CD47 and Liver
Spleen Antibodies	>27 publications with CD47 and Spleen
Skin Antibodies	>26 publications with CD47 and Skin