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Biglycan (BGN) Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS141288

Description: BGN produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 340 amino acids (38-368 a.a.) and having a molecular mass of 38.3kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa). BGN is expressed with… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Biglycan (BGN), Active Protein
Full Product Name
Recombinant Human Biglycan, Sf9
Product Gene Name
BGN active protein
Product Synonym Names
Biglycan Human Recombinant, Sf9; BGN; DSPG1; MRLS; PG-S1; PGI; SEMDX; SLRR1A; Biglycan; Bone/cartilage proteoglycan I; Biglycan Proteoglycan; MRLS; BGN Human, Sf9
Sequence
ADPDEEASGA DTSGVLDPDS VTPTYSAMCP FGCHCHLRVV QCSDLGLKSV PKEISPDTTL LDLQNNDISE LRKDDFKGLQ HLYALVLVNN KISKIHEKAF SPLRKLQKLY ISKNHLVEIP PNLPSSLVEL RIHDNRIRKV PKGVFSGLRN MNCIEMGGNP LENSGFEPGA FDGLKLNYLR ISEAKLTGIP KDLPETLNEL HLDHNKIQAI ELEDLLRYSK LYRLGLGHNQ IRMIENGSLS FLPTLRELHL DNNKLARVPS GLPDLKLLQV VYLHSNNITK VGVNDFCPMG FGVKRAYYNG ISLFNNPVPY WEVQPATFRC VTDRLAIQFG NYKKHHHHHH .
Host
Sf9, Insect cells
Form/Format
Sterile filtered colorless solution.
Solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Molecular Weight
41,654 Da
3D Structure
ModBase 3D Structure for P21810
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
The ED50 for this effect is <= 20 ug/ml. The specific activity is measured by inhibiting the cell growth using 3T3 L1 mouse embryonic fibroblast adipose-like cells.

Product Categories/Family for BGN active protein

Recombinant & Natural Proteins

Other Notes

Small volumes of BGN active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BGN purchase

MBS141288 is an active protein targeting BGN. Also known as Recombinant Human Biglycan, Sf9. Host: Sf9, Insect cells.

Additional Details

NCBI/Uniprot data below describe general gene information for BGN. It may not necessarily be applicable to this product.

NCBI GI #
266762
NCBI GeneID
633
NCBI Accession #
P21810.2
UniProt Primary Accession #
P21810
UniProt Secondary Accession #
P13247; D3DWU3
UniProt Related Accession #
P21810
NCBI Official Full Name
Biglycan
NCBI Official Synonym Full Names
biglycan
NCBI Official Symbol
BGN
NCBI Official Synonym Symbols
PGI; MRLS; DSPG1; PG-S1; SEMDX; SLRR1A
UniProt Protein Name
Biglycan
UniProt Synonym Protein Names
Bone/cartilage proteoglycan I; PG-S1
Protein Family
Biglycan
UniProt Gene Name
BGN
UniProt Synonym Gene Names
SLRR1A
NCBI Protein Information
biglycan

NCBI Summary for BGN

This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and collagen fibril assembly in multiple tissues. This protein may also regulate inflammation and innate immunity. Additionally, the encoded protein may contribute to atherosclerosis and aortic valve stenosis in human patients. This gene and the related gene decorin are thought to be the result of a gene duplication. [provided by RefSeq, Nov 2015]
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UniProt Comments for BGN

May be involved in collagen fiber assembly.

Research Articles on BGN

1. The differential immunoexpression of perlecan and biglycan in these types of ameloblastomas suggests their participation in the developmental process of these tumors.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BGN active protein

 Reference Product  PubMed Publications
 COL1A1 active protein  >6 publications with BGN and COL1A1
 BMP4 active protein  >5 publications with BGN and BMP4
 COL1A2 active protein  >3 publications with BGN and COL1A2

Pathways associated with BGN active protein

 Products by Pathway  Pathway Diagram
 A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway antibodies  A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway Diagram
 CS/DS Degradation Pathway antibodies  CS/DS Degradation Pathway Diagram
 Chondroitin Sulfate Biosynthesis Pathway antibodies  Chondroitin Sulfate Biosynthesis Pathway Diagram
 Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies  Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
 Defective B3GALT6 Causes EDSP2 And SEMDJL1 Pathway antibodies  Defective B3GALT6 Causes EDSP2 And SEMDJL1 Pathway Diagram
 Defective B3GAT3 Causes JDSSDHD Pathway antibodies  Defective B3GAT3 Causes JDSSDHD Pathway Diagram
 Defective B4GALT7 Causes EDS, Progeroid Type Pathway antibodies  Defective B4GALT7 Causes EDS, Progeroid Type Pathway Diagram
 Defective CHST14 Causes EDS, Musculocontractural Type Pathway antibodies  Defective CHST14 Causes EDS, Musculocontractural Type Pathway Diagram
 Defective CHST3 Causes SEDCJD Pathway antibodies  Defective CHST3 Causes SEDCJD Pathway Diagram
 Defective CHSY1 Causes TPBS Pathway antibodies  Defective CHSY1 Causes TPBS Pathway Diagram

Diseases associated with BGN active protein

 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >36 publications with BGN and Fibrosis
 Inflammation Antibodies  >33 publications with BGN and Inflammation
 Kidney Diseases Antibodies  >23 publications with BGN and Kidney Diseases
 Necrosis Antibodies  >23 publications with BGN and Necrosis
 Carcinoma Antibodies  >14 publications with BGN and Carcinoma
 Adenocarcinoma Antibodies  >10 publications with BGN and Adenocarcinoma
 Arthritis, Rheumatoid Antibodies  >10 publications with BGN and Arthritis, Rheumatoid
 Hypertension Antibodies  >7 publications with BGN and Hypertension
 Breast Neoplasms Antibodies  >6 publications with BGN and Breast Neoplasms
 Liver Diseases Antibodies  >6 publications with BGN and Liver Diseases

Organs/Tissues associated with BGN active protein

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >141 publications with BGN and Bone
 Connective Tissue Antibodies  >93 publications with BGN and Connective Tissue
 Vascular Antibodies  >80 publications with BGN and Vascular
 Muscle Antibodies  >78 publications with BGN and Muscle
 Blood Antibodies  >65 publications with BGN and Blood
 Mouth Antibodies  >43 publications with BGN and Mouth
 Kidney Antibodies  >40 publications with BGN and Kidney
 Skin Antibodies  >40 publications with BGN and Skin
 Heart Antibodies  >31 publications with BGN and Heart
 Lung Antibodies  >30 publications with BGN and Lung
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