ELOB Recombinant Protein – Cat# MBS141302

Elongin B (ELOB) Recombinant Protein

Name: ELOB Recombinant Protein; Elongin B; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS141302
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS141302

Introduction: Elongin B (Elob) is a subunit of the transcription factor B (SIII) complex. SIII complex is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. The SIII… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Elongin B (ELOB), Recombinant Protein

Full Product Name

Elongin B Mouse Recombinant

Product Gene Name

ELOB recombinant protein

Product Synonym Names

Transcription elongation factor B polypeptide 2; TCEB2; RNA polymerase IItranscription factor SIII subunit B; SIII p18; EloB; Elongin 18 kDa subunit

Sequence

MGSSHHHHHH SSGLVPRGSH MGSMDVFLMI RRHKTTIFTD AKESSTVFEL KRIVEGILKR PPEEQRLYKD DQLLDDGKTL GECGFTSQTA RPQAPATVGL AFRADDTFEA LRIEPFSSPP ELPDVMKPQD SGGSANEQAV Q

Host

E Coli

Form/Format

Sterile filtered colorless solution. The protein (1mg/ml) contains PBS pH-7.4 containing 1mM DTT and 10% Glycerol.

Purity/Purification

Greater than 95.0% as determined by SDS-PAGE.

Preparation and Storage

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

3D Structure

ModBase 3D Structure for Q15370

Product Categories/Family for ELOB recombinant protein

Recombinant & Natural Proteins

Other Notes

Small volumes of ELOB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ELOB purchase

MBS141302 is a recombinant protein targeting ELOB. Also known as Elongin B Mouse Recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for ELOB. It may not necessarily be applicable to this product.

UniProt Primary Accession #

Q15370

UniProt Secondary Accession #

B7WPD3

UniProt Related Accession #

Q15370

GenBank Nucleotide #

NM_007108.3

Protein Family

Transcription elongation factor B polypeptide

NCBI Summary for ELOB

This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, Aug 2008]

UniProt Comments for ELOB

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7638163). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells ().

Research Articles on ELOB

1. Study shows that TCEB2 is involved in the development of acquired resistance to bevacizumab in ovarian cancer cells via the mechanisms of suppression of VEGF-A expression by promoting HIF-1alpha degradation and induction of interleukin-8 (IL-8) expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with ELOB recombinant protein

Disease Name	Pubmed Publications
Carcinoma Antibodies	>4 publications with ELOB and Carcinoma
Breast Neoplasms Antibodies	>1 publications with ELOB and Breast Neoplasms
Kidney Diseases Antibodies	>1 publications with ELOB and Kidney Diseases

Organs/Tissues associated with ELOB recombinant protein

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>2 publications with ELOB and Kidney
Adrenal Gland Antibodies	>1 publications with ELOB and Adrenal Gland
Brain Antibodies	>1 publications with ELOB and Brain