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Voltage-Dependent L-Type Calcium Channel Subunit Beta-2 (CACNB2) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1413391

This gene encodes a subunit of a voltage-dependent calcium channel protein which is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome which is an… More details

$1470 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Voltage-dependent L-type calcium channel subunit beta-2 (Cacnb2), Recombinant Protein
Full Product Name
Recombinant Mouse Voltage-dependent L-type calcium channel subunit beta-2 (Cacnb2)
Product Gene Name
Cacnb2 recombinant protein
Product Synonym Gene Name
Cacnb2
Sequence
MVQSDTSKSP PVAAVAQESQ MELLESAAPA GALGAQSYGK GARRKNRFKG SDGSTSSDTT SNSFVRQGSA DSYTSRPSDS DVSLEEDREA VRREAERQAQ AQLEKAKTKP VAFAVRTNVR YSAAQEDDVP VPGMAISFEA KDFLHVKEKF NNDWWIGRLV KEGCEIGFIP SPVKLENMRL QHEQRAKQGK FYSSKSGGNS SSSLGDIVPS SRKSTPPSSA IDIDATGLDA EENDIPANHR SPKPSANSVT SPHSKEKRMP FFKKTEHTPP YDVVPSMRPV VLVGPSLKGY EVTDMMQKAL FDFLKHRFEG RISITRVTAD ISLAKRSVLN NPSKHAIIER SNTRSSLAEV QSEIERIFEL ARTLQLVVLD ADTINHPAQL SKTSLAPIIV YVKISSPKVL QRLIKSRGKS QAKHLNVQMV AADKLAQCPP QESFDVILDE NQLEDACEHL ADYLEAYWKA THPPSGNLPN PLLSRTLASS TLPLSPTLAS NSQGSQGDQR PDRSAPRSAS QAEEEPCLEP VKKSQHRSSS ATHQNHRSGT GRGLSRQETF DSETQESRDS AYVEPKEDYS HEHVDRYVPH REHNHREETH SSNGHRHRES RHRSRDMGRD QDHNECIKQR SRHKSKDRYC DKEGEVISKR RNEAGEWNRD VYIRQ
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
64,714 Da
Sequence Positions
1-655, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q8CC27
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Cacnb2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Cacnb2 purchase

MBS1413391 is a recombinant protein targeting Cacnb2. Also known as Recombinant Mouse Voltage-dependent L-type calcium channel subunit beta-2 (Cacnb2). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Cacnb2. It may not necessarily be applicable to this product.

NCBI GI #
828747400
NCBI GeneID
12296
NCBI Accession #
NP_001296448.1
UniProt Primary Accession #
Q8CC27
UniProt Secondary Accession #
Q8C5J5; Q9CTQ6; A2ASJ8
UniProt Related Accession #
Q8CC27
GenBank Nucleotide #
NM_001309519.1
NCBI Official Full Name
voltage-dependent L-type calcium channel subunit beta-2 isoform 3
NCBI Official Synonym Full Names
calcium channel, voltage-dependent, beta 2 subunit
NCBI Official Symbol
Cacnb2
NCBI Official Synonym Symbols
CAB2; Cchb2; AW060387; Cavbeta2
UniProt Protein Name
Voltage-dependent L-type calcium channel subunit beta-2
UniProt Synonym Protein Names
Calcium channel voltage-dependent subunit beta 2
Protein Family
Voltage-dependent L-type calcium channel
UniProt Gene Name
Cacnb2
UniProt Synonym Gene Names
Cacnlb2; CAB2
NCBI Protein Information
voltage-dependent L-type calcium channel subunit beta-2

UniProt Comments for Cacnb2

The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.

Research Articles on Cacnb2

1. L-type Ca2+ channels in the caveolae microdomain do not affect cardiac function and are not necessary for the regulation of hypertrophic signaling in the adult mouse heart.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Cacnb2 recombinant protein

 Products by Pathway  Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Depolarization Of The Presynaptic Terminal Triggers The Opening Of Calcium Channels Pathway antibodies  Depolarization Of The Presynaptic Terminal Triggers The Opening Of Calcium Channels Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram

Diseases associated with Cacnb2 recombinant protein

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >15 publications with Cacnb2 and Heart Diseases
 Nervous System Diseases Antibodies  >10 publications with Cacnb2 and Nervous System Diseases
 Brugada Syndrome 4 Antibodies  >4 publications with Cacnb2 and Brugada Syndrome 4
 Congenital Abnormalities Antibodies  >3 publications with Cacnb2 and Congenital Abnormalities
 Hypertrophy Antibodies  >2 publications with Cacnb2 and Hypertrophy
 Inflammation Antibodies  >2 publications with Cacnb2 and Inflammation
 Immune System Diseases Antibodies  >2 publications with Cacnb2 and Immune System Diseases
 Lung Neoplasms Antibodies  >1 publications with Cacnb2 and Lung Neoplasms
 Weight Loss Antibodies  >1 publications with Cacnb2 and Weight Loss
 Atrophy Antibodies  >1 publications with Cacnb2 and Atrophy

Organs/Tissues associated with Cacnb2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >25 publications with Cacnb2 and Heart
 Brain Antibodies  >13 publications with Cacnb2 and Brain
 Embryonic Tissue Antibodies  >2 publications with Cacnb2 and Embryonic Tissue
 Adrenal Gland Antibodies  >1 publications with Cacnb2 and Adrenal Gland
 Spinal Cord Antibodies  >1 publications with Cacnb2 and Spinal Cord
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