Mouse mGPT2 Recombinant Protein – Cat# MBS141354

Glutamic-Pyruvate Transaminase 2 (mGPT2) Mouse Recombinant Protein

Name: mGPT2 Recombinant Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS141354
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS141354

Introduction: Glutamic-Pyruvate Transaminase 2 (GPT2) catalyzes the reversible transamination among alanine and 2-oxoglutarate to create pyruvate and glutamate. GPT2 expressed mainly in muscle, fat and kidney and participates in the intermediary metabolism of… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Glutamic-Pyruvate Transaminase 2 (mGPT2), Recombinant Protein

Full Product Name

Recombinant Mouse Glutamic-Pyruvate Transaminase 2

Product Gene Name

mGPT2 recombinant protein

Product Synonym Names

Glutamic-Pyruvate Transaminase 2 Mouse Recombinant; ALT2; AAT2; Alanine aminotransferase 2; Glutamate pyruvate transaminase 2; Glutamic--alanine transaminase 2; Glutamic--pyruvic transaminase 2; GPT2 Mouse

Sequence

MGSSHHHHHH SSGLVPRGSH MQRAAVLVRR GSCPRASGPW GRSHSSAAAE ASAALKVRPE RSPRDRILTL ESMNPQVKAV EYAVRGPIVL KAGEIEMELQ RGIKKPFTEV IRANIGDAHA MGQQPITFLR QVMALCTYPN LLNSPSFPED AKKRARRILQ ACGGNSLGSY SASQGVNCIR EDVAAFITRR DGVPADPDNI YLTTGASDGI STILKLLVSG GGKSRTGVMI PIPQYPLYSA VISELDAVQV NYYLDEENCW ALNVDELRRA LRQAKDHCDP KVLCIINPGN PTGQVQSRKC IEDVIHFAWE EKLFLLADEV YQDNVYSPDC RFHSFKKVLY QMGHEYSSNV ELASFHSTSK GYMGECGYRG GYMEVINLHP EIKGQLVKLL SVRLCPPVSG QAAMDIVVNP PEPGEESFEQ FSREKEFVLG NLAKKAKLTE DLFNQVPGIQ CNPLQGAMYA FPRILIPAKA VEAAQSHKMA PDMFYCMKLL EETGICVVPG SGFGQREGTY HFRMTILPPV DKLKTVLHKV KDFHLKFLEQ

Host

E Coli

Form/Format

Sterile Filtered Colorless Solution
Solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 7.5), 20% glycerol, and 2mM DTT.

Purity/Purification

>85% as determined by SDS-PAGE

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze/thaw cycles.

OMIM

138210

3D Structure

ModBase 3D Structure for Q8TD30

Product Categories/Family for mGPT2 recombinant protein

Enzymes

Other Notes

Small volumes of mGPT2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for mGPT2 purchase

MBS141354 is a recombinant protein targeting mGPT2. Also known as Recombinant Mouse Glutamic-Pyruvate Transaminase 2. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for mGPT2. It may not necessarily be applicable to this product.

NCBI GI #

74730602

NCBI GeneID

84706

NCBI Accession #

Q8TD30.1

UniProt Primary Accession #

Q8TD30

UniProt Related Accession #

Q8TD30

NCBI Official Full Name

Alanine aminotransferase 2

NCBI Official Synonym Full Names

glutamic--pyruvic transaminase 2

NCBI Official Symbol

GPT2

NCBI Official Synonym Symbols

ALT2; GPT 2; MRT49

UniProt Protein Name

Alanine aminotransferase 2

UniProt Synonym Protein Names

Glutamate pyruvate transaminase 2; GPT 2; Glutamic--alanine transaminase 2; Glutamic--pyruvic transaminase 2

UniProt Gene Name

GPT2

UniProt Synonym Gene Names

AAT2; ALT2; ALT2; GPT 2

UniProt Entry Name

ALAT2_HUMAN

NCBI Protein Information

alanine aminotransferase 2

NCBI Summary for mGPT2

This gene encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Alanine transaminases play roles in gluconeogenesis and amino acid metabolism in many tissues including skeletal muscle, kidney, and liver. Activating transcription factor 4 upregulates this gene under metabolic stress conditions in hepatocyte cell lines. A loss of function mutation in this gene has been associated with developmental encephalopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

UniProt Comments for mGPT2

GPT2: Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; EC 2.6.1.2; Amino Acid Metabolism - alanine, aspartate and glutamate; Transferase

Chromosomal Location of Human Ortholog: 16q12.1

Cellular Component: mitochondrial matrix

Molecular Function: alanine transaminase activity; pyridoxal phosphate binding

Biological Process: amino acid biosynthetic process; L-alanine metabolic process; 2-oxoglutarate metabolic process; L-alanine catabolic process

Disease: Mental Retardation, Autosomal Recessive 49

Research Articles on mGPT2

1. We here describe novel compound heterozygous missense variants, NM_133443:c.[400C>T] and NM_133443:[1435G>A], in the glutamic-pyruvic transaminase 2 (GPT2) gene in a large consanguineous family with two affected siblings diagnosed with microcephaly intellectual disability and developmental delay (IDD).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with mGPT2 recombinant protein

Reference Product	PubMed Publications
LDHB recombinant protein	>1 publications with mGPT2 and LDHB

Pathways associated with mGPT2 recombinant protein

Products by Pathway	Pathway Diagram
2-Oxocarboxylic Acid Metabolism Pathway antibodies	2-Oxocarboxylic Acid Metabolism Pathway Diagram
2-Oxocarboxylic Acid Metabolism Pathway antibodies	2-Oxocarboxylic Acid Metabolism Pathway Diagram
Alanine, Aspartate And Glutamate Metabolism Pathway antibodies	Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
Alanine, Aspartate And Glutamate Metabolism Pathway antibodies	Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
Amino Acid Synthesis And Interconversion (transamination) Pathway antibodies	Amino Acid Synthesis And Interconversion (transamination) Pathway Diagram
Biosynthesis Of Amino Acids Pathway antibodies	Biosynthesis Of Amino Acids Pathway Diagram
Biosynthesis Of Amino Acids Pathway antibodies	Biosynthesis Of Amino Acids Pathway Diagram
Carbon Metabolism Pathway antibodies	Carbon Metabolism Pathway Diagram
Carbon Metabolism Pathway antibodies	Carbon Metabolism Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram

Diseases associated with mGPT2 recombinant protein

Disease Name	Pubmed Publications
Fatty Liver Antibodies	>3 publications with mGPT2 and Fatty Liver
Disease Models, Animal Antibodies	>1 publications with mGPT2 and Disease Models, Animal
Fetal Growth Retardation Antibodies	>1 publications with mGPT2 and Fetal Growth Retardation
Liver Diseases Antibodies	>1 publications with mGPT2 and Liver Diseases

Organs/Tissues associated with mGPT2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>12 publications with mGPT2 and Blood
Liver Antibodies	>5 publications with mGPT2 and Liver
Adipose Tissue Antibodies	>2 publications with mGPT2 and Adipose Tissue
Muscle Antibodies	>2 publications with mGPT2 and Muscle
Heart Antibodies	>1 publications with mGPT2 and Heart
Placenta Antibodies	>1 publications with mGPT2 and Placenta
Lung Antibodies	>1 publications with mGPT2 and Lung
Thyroid Antibodies	>1 publications with mGPT2 and Thyroid
Intestine Antibodies	>1 publications with mGPT2 and Intestine
Kidney Antibodies	>1 publications with mGPT2 and Kidney