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Single-Strand Selective Monofunctional Uracil DNA Glycosylase (SMUG1) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1413892

MBS1413892 is a recombinant protein targeting Smug1. Also known as Recombinant Mouse Single-strand selective monofunctional uracil DNA glycosylase (Smug1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$965 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Single-strand selective monofunctional uracil DNA glycosylase (Smug1), Recombinant Protein
Full Product Name
Recombinant Mouse Single-strand selective monofunctional uracil DNA glycosylase (Smug1)
Product Gene Name
Smug1 recombinant protein
Product Synonym Gene Name
Smug1
Sequence
MAASQTFPLG PTHEPASALM EPLPCTRSLA EGFLEEELRL NAELSQLQFP EPVGVIYNPV DYAWEPHRNY VTRYCQGPKE VLFLGMNPGP FGMAQTGVPF GEVNVVRDWL GVGGPVLTPP QEHPKRPVLG LECPQSEVSG ARFWGFFRTL CGQPQVFFRH CFVHNLCPLL FLAPSGRNLT PAELPAKQRE QLLSICDAAL CRQVQLLGVR LVVGVGRLAE QRARRALAGL TPEVQVEGLL HPSPRSAQAN KGWEAAARER LQELGLLPLL TDEGSARPT
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
30,654 Da
Sequence Positions
1-279, full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q6P5C5
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Smug1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Smug1. It may not necessarily be applicable to this product.

NCBI GI #
40254179
NCBI GeneID
71726
NCBI Accession #
NP_082161.2
UniProt Primary Accession #
Q6P5C5
UniProt Secondary Accession #
Q9DBV1
UniProt Related Accession #
Q6P5C5
GenBank Nucleotide #
NM_027885.3
NCBI Official Full Name
single-strand selective monofunctional uracil DNA glycosylase
NCBI Official Synonym Full Names
single-strand selective monofunctional uracil DNA glycosylase
NCBI Official Symbol
Smug1
NCBI Official Synonym Symbols
C85220; 1200013B09Rik; A930006H09Rik
UniProt Protein Name
Single-strand selective monofunctional uracil DNA glycosylase
Protein Family
Single-strand selective monofunctional uracil DNA glycosylase
UniProt Gene Name
Smug1
NCBI Protein Information
single-strand selective monofunctional uracil DNA glycosylase

UniProt Comments for Smug1

Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration.
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Research Articles on Smug1

1. Nonetheless, using a highly MSH2-dependent mechanism, Ung(-/-) Smug1(-/-) mice can still produce detectable levels of switched isotypes, especially IgG1

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Smug1 recombinant protein

 Reference Product  PubMed Publications
 Ung recombinant protein  >31 publications with Smug1 and Ung
 Tdg recombinant protein  >20 publications with Smug1 and Tdg
 Mbd4 recombinant protein  >10 publications with Smug1 and Mbd4
 Xrcc1 recombinant protein  >9 publications with Smug1 and Xrcc1
 Ogg1 recombinant protein  >4 publications with Smug1 and Ogg1
 Neil1 recombinant protein  >3 publications with Smug1 and Neil1
 Nthl1 recombinant protein  >3 publications with Smug1 and Nthl1
 Neil2 recombinant protein  >2 publications with Smug1 and Neil2

Pathways associated with Smug1 recombinant protein

 Products by Pathway  Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base-Excision Repair, AP Site Formation Pathway antibodies  Base-Excision Repair, AP Site Formation Pathway Diagram
 Base-free Sugar-phosphate Removal Via The Single-nucleotide Replacement Pathway antibodies  Base-free Sugar-phosphate Removal Via The Single-nucleotide Replacement Pathway Diagram
 Cleavage Of The Damaged Pyrimidine Pathway antibodies  Cleavage Of The Damaged Pyrimidine Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Depyrimidination Pathway antibodies  Depyrimidination Pathway Diagram
 Displacement Of DNA Glycosylase By APE1 Pathway antibodies  Displacement Of DNA Glycosylase By APE1 Pathway Diagram
 Recognition And Association Of DNA Glycosylase With Site Containing An Affected Pyrimidine Pathway antibodies  Recognition And Association Of DNA Glycosylase With Site Containing An Affected Pyrimidine Pathway Diagram

Diseases associated with Smug1 recombinant protein

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >5 publications with Smug1 and Carcinoma
 Neoplasms, Experimental Antibodies  >2 publications with Smug1 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >2 publications with Smug1 and Breast Neoplasms
 Carcinoma, Squamous Cell Antibodies  >2 publications with Smug1 and Carcinoma, Squamous Cell
 Colonic Neoplasms Antibodies  >2 publications with Smug1 and Colonic Neoplasms
 Translocation, Genetic Antibodies  >1 publications with Smug1 and Translocation, Genetic
 Inflammation Antibodies  >1 publications with Smug1 and Inflammation
 Disease Models, Animal Antibodies  >1 publications with Smug1 and Disease Models, Animal
 Lymphoma Antibodies  >1 publications with Smug1 and Lymphoma
 Nervous System Diseases Antibodies  >1 publications with Smug1 and Nervous System Diseases

Organs/Tissues associated with Smug1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1 publications with Smug1 and Brain
 Lung Antibodies  >1 publications with Smug1 and Lung
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