Human CDC34 Recombinant Protein – Cat# MBS141413

Cell Division Cycle 34 (CDC34) Human Recombinant Protein

Name: CDC34 Recombinant Protein; Cell Division Cycle 34; Human; MyBioSource
Brand: MyBioSource
SKU: MBS141413
Price: 580 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS141413

Introduction: CDC34 takes part in the control of cell cycle and DNA replication. Cdc34 in association with different E3 complexes, including SCF, targets many different substrates for ubiquitination and degradation during cell division, signal transduction,… More details

$580 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Cell Division Cycle 34 (CDC34), Recombinant Protein

Full Product Name

Recombinant Human Cell Division Cycle 34

Product Gene Name

CDC34 recombinant protein

Product Synonym Names

UB2R1; CDC-34; Ubiquitin-conjugating enzyme E2 R1; Ubiquitin-protein ligase R1; Ubiquitin-conjugating enzyme E2-32 kDa complementing; E2-CDC34; CDC34; EC 6.3.2.19; UBC3; UBE2R1; CDC34 Human; Cell Division Cycle 34 Human Recombinant

Sequence

Amino acid: MARPLVPSSQ KALLLELKGL QEEPVEGFRV TLVDEGDLYN WEVAIFGPPN TYYEGGYFKA RLKFPIDYPY SPPAFRFLTK MWHPNIYETG DVCISILHPP VDDPQSGELP SERWNPTQNV RTILLSVISL LNEPNTFSPA NVDASVMYRK WKESKGKDRE YTDIIRKQVL GTKVDAERDG VKVPTTLAEY CVKTKAPAPD EGSDLFYDDY YEDGEVEEEA DSCFGDDEDD SGTEES.

Host

E Coli

Form/Format

Sterile filtered colorless solution.
CDC34 is supplied as a 0.2 um filtered solution conteining 50mM HEPES, pH 7.0, 10 % Glycerol, 125mM NaCl, , 5 % Trehalose and 1 mM DTT.

Purity/Purification

>95.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks.
Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.

OMIM

116948

3D Structure

ModBase 3D Structure for P49427

Product Categories/Family for CDC34 recombinant protein

ENZYMES

Other Notes

Small volumes of CDC34 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDC34 purchase

MBS141413 is a recombinant protein targeting CDC34. Also known as Recombinant Human Cell Division Cycle 34. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CDC34. It may not necessarily be applicable to this product.

NCBI GI #

16357477

NCBI GeneID

997

NCBI Accession #

NP_004350.1

UniProt Primary Accession #

P49427

UniProt Related Accession #

P49427

GenBank Nucleotide #

NP_004350.1

NCBI Official Full Name

ubiquitin-conjugating enzyme E2 R1

NCBI Official Synonym Full Names

cell division cycle 34, ubiqiutin conjugating enzyme

NCBI Official Symbol

CDC34

NCBI Official Synonym Symbols

UBC3; UBCH3; UBE2R1; E2-CDC34

UniProt Protein Name

Ubiquitin-conjugating enzyme E2 R1

UniProt Synonym Protein Names

Ubiquitin-conjugating enzyme E2-32 kDa complementing; Ubiquitin-conjugating enzyme E2-CDC34; Ubiquitin-protein ligase R1

Protein Family

Ubiquitin-conjugating enzyme

UniProt Gene Name

CDC34

UniProt Synonym Gene Names

UBCH3; UBE2R1

UniProt Entry Name

UB2R1_HUMAN

NCBI Protein Information

ubiquitin-conjugating enzyme E2 R1

NCBI Summary for CDC34

The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. [provided by RefSeq, Jul 2008]

UniProt Comments for CDC34

CDC34: a member of the ubiquitin-conjugating enzyme family. Is a part of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for ubiquitin-mediated degradation of cell cycle G1 regulators. Required for the initiation of DNA replication.

Protein type: Ligase; Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.19

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein binding; small conjugating protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; ATP binding; ligase activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; DNA replication initiation; positive regulation of neuron apoptosis; protein modification process; protein ubiquitination; G1/S transition of mitotic cell cycle

Research Articles on CDC34

1. study finds that mutation of the catalytically active cysteine to serine (C93S) results in the reduced ubiquitination, increased stability, and attenuated degradation rate of CDC34; Through semi-quantitative proteomics, identified the CDC34-interacting proteins and discovered that the wild-type and mutant proteins have many differentially interacted proteins

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CDC34 recombinant protein

Reference Product	PubMed Publications
CUL1 recombinant protein	>22 publications with CDC34 and CUL1
RBX1 recombinant protein	>15 publications with CDC34 and RBX1
CDKN1B recombinant protein	>9 publications with CDC34 and CDKN1B
UBC recombinant protein	>9 publications with CDC34 and UBC
BTRC recombinant protein	>4 publications with CDC34 and BTRC
FBXW7 recombinant protein	>3 publications with CDC34 and FBXW7
SKP2 recombinant protein	>3 publications with CDC34 and SKP2
ATF5 recombinant protein	>2 publications with CDC34 and ATF5

Pathways associated with CDC34 recombinant protein

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies	Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies	Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
Herpes Simplex Infection Pathway antibodies	Herpes Simplex Infection Pathway Diagram
Herpes Simplex Infection Pathway antibodies	Herpes Simplex Infection Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
TNF-alpha/NF-kB Signaling Pathway antibodies	TNF-alpha/NF-kB Signaling Pathway Diagram
Ubiquitin Mediated Proteolysis Pathway antibodies	Ubiquitin Mediated Proteolysis Pathway Diagram
Ubiquitin Mediated Proteolysis Pathway antibodies	Ubiquitin Mediated Proteolysis Pathway Diagram

Diseases associated with CDC34 recombinant protein

Disease Name	Pubmed Publications
Liver Diseases Antibodies	>2 publications with CDC34 and Liver Diseases
Carcinoma Antibodies	>2 publications with CDC34 and Carcinoma
Nervous System Diseases Antibodies	>2 publications with CDC34 and Nervous System Diseases
Necrosis Antibodies	>2 publications with CDC34 and Necrosis
Neoplasms, Experimental Antibodies	>1 publications with CDC34 and Neoplasms, Experimental
Cell Transformation, Neoplastic Antibodies	>1 publications with CDC34 and Cell Transformation, Neoplastic
Hepatitis Antibodies	>1 publications with CDC34 and Hepatitis
Weight Loss Antibodies	>1 publications with CDC34 and Weight Loss
Inflammation Antibodies	>1 publications with CDC34 and Inflammation
Kidney Diseases Antibodies	>1 publications with CDC34 and Kidney Diseases

Organs/Tissues associated with CDC34 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>4 publications with CDC34 and Brain
Blood Antibodies	>3 publications with CDC34 and Blood
Liver Antibodies	>2 publications with CDC34 and Liver
Embryonic Tissue Antibodies	>2 publications with CDC34 and Embryonic Tissue
Prostate Antibodies	>2 publications with CDC34 and Prostate
Muscle Antibodies	>2 publications with CDC34 and Muscle
Adipose Tissue Antibodies	>1 publications with CDC34 and Adipose Tissue
Nerve Antibodies	>1 publications with CDC34 and Nerve
Connective Tissue Antibodies	>1 publications with CDC34 and Connective Tissue
Kidney Antibodies	>1 publications with CDC34 and Kidney