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Lymphotactin (XCL1) Mouse Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS141467

Introduction: XCL1 is a small cytokine belongs to the XC chemokine family that is also known as lymphotactin. XCL1 is found in high levels in spleen, thymus, intestine and peripheral blood leukocytes, and at lower levels in lung, prostate gland and ovary.… More details

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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Lymphotactin (XCL1), Active Protein
Full Product Name
Recombinant Mouse Lymphotactin (XCL1)
Product Gene Name
XCL1 active protein
Product Synonym Names
XCL1; Cytokine SCM-1; ATAC; Lymphotaxin; SCM-1-alpha; Small inducible cytokine C1; XC chemokine ligand 1; LTN; LPTN; SCM1; SCM-1; SCYC1; SCM-1a; Lymphotactin Mouse; mLymphotactin; Lymphotactin (XCL1) Mouse Recombinant
Sequence
Amino acid: VGTEVLEESS CVNLQTQRLP VQKIKTYIIW EGAMRAVIFV TKRGLKICAD PEAKWVKAAI KTVDGRASTR KNMAETVPTG AQRSTSTAIT LTG.
Host
E Coli
Form/Format
Sterile Filtered White lyophilized (freeze-dried) powder
Lyophilized from a 0.2um filtered concentrated solution in PBS, pH 7.4.
Purity/Purification
>97.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE
Preparation and Storage
Lyophilized XCL1 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C.
Upon reconstitution Lymphotactin should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.
Please prevent freeze-thaw cycles.
3D Structure
ModBase 3D Structure for P47993
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility
It is recommended to reconstitute the lyophilized Lymphotactin in sterile 18Momega-cm H2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.
Biological Activity
The ED50 as determined by a chemotaxis bioassay using human XCR1 transfected murine BaF3 cells is < 100ng/ml, corresponding to a specific activity of > 1.0 × 104 IU/mg.

Product Categories/Family for XCL1 active protein

CHEMOKINES

Other Notes

Small volumes of XCL1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for XCL1 purchase

MBS141467 is an active protein targeting XCL1. Also known as Recombinant Mouse Lymphotactin (XCL1). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for XCL1. It may not necessarily be applicable to this product.

NCBI GI #
1346472
NCBI GeneID
16963
NCBI Accession #
P47993.1
UniProt Primary Accession #
P47993
UniProt Related Accession #
P47993
NCBI Official Full Name
Lymphotactin
NCBI Official Synonym Full Names
chemokine (C motif) ligand 1
NCBI Official Symbol
Xcl1
NCBI Official Synonym Symbols
LTN; ATAC; Lptn; SCM-1; Scyc1; SCM-1a; AI661682
UniProt Protein Name
Lymphotactin
UniProt Synonym Protein Names
C motif chemokine 1; Cytokine SCM-1; Lymphotaxin; Small-inducible cytokine C1
Protein Family
Lymphotactin
UniProt Gene Name
Xcl1
UniProt Synonym Gene Names
Lptn; Ltn; Scyc1
UniProt Entry Name
XCL1_MOUSE
NCBI Protein Information
lymphotactin

UniProt Comments for XCL1

XCL1: Chemotactic activity for lymphocytes but not for monocytes or neutrophils. Belongs to the intercrine gamma family.

Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Cellular Component: extracellular space; cell; extracellular region; intracellular; cytosol

Molecular Function: protein homodimerization activity; chemokine activity; chemokine receptor binding; cytokine activity

Biological Process: positive regulation of T cell mediated cytotoxicity; response to virus; negative regulation of transcription factor activity; positive regulation of T cell cytokine production; positive regulation of leukocyte chemotaxis; positive regulation of immune response to tumor cell; negative regulation of T cell cytokine production; chemotaxis; positive regulation of interleukin-10 production; negative regulation of interleukin-2 production; cell-cell signaling; release of sequestered calcium ion into cytosol; negative regulation of interferon-gamma production; regulation of inflammatory response; positive regulation of innate immune response; immune response; positive regulation of release of sequestered calcium ion into cytosol; negative regulation of transcription, DNA-dependent
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Research Articles on XCL1

1. A highly active form of XCL1 is a promising vaccine adjuvant for cross-presenting DCs to induce antigen-specific effector and memory CD8(+) T cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with XCL1 active protein

 Reference Product  PubMed Publications
 Xcr1 active protein  >28 publications with XCL1 and Xcr1
 Cxcr3 active protein  >9 publications with XCL1 and Cxcr3
 Ccr1 active protein  >5 publications with XCL1 and Ccr1
 Ccr7 active protein  >2 publications with XCL1 and Ccr7
 Ccl9 active protein  >2 publications with XCL1 and Ccl9
 Ccl6 active protein  >1 publications with XCL1 and Ccl6

Pathways associated with XCL1 active protein

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram

Diseases associated with XCL1 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >27 publications with XCL1 and Inflammation
 Necrosis Antibodies  >17 publications with XCL1 and Necrosis
 Disease Models, Animal Antibodies  >16 publications with XCL1 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >14 publications with XCL1 and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >6 publications with XCL1 and Nervous System Diseases
 Colonic Neoplasms Antibodies  >4 publications with XCL1 and Colonic Neoplasms
 Eye Diseases Antibodies  >4 publications with XCL1 and Eye Diseases
 Kidney Diseases Antibodies  >3 publications with XCL1 and Kidney Diseases
 Lymphoma Antibodies  >3 publications with XCL1 and Lymphoma
 Ovarian Neoplasms Antibodies  >3 publications with XCL1 and Ovarian Neoplasms

Organs/Tissues associated with XCL1 active protein

 Organ/Tissue Name  Pubmed Publications
 Spleen Antibodies  >18 publications with XCL1 and Spleen
 Thymus Antibodies  >8 publications with XCL1 and Thymus
 Embryonic Tissue Antibodies  >2 publications with XCL1 and Embryonic Tissue
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