Mouse mIL1RA Active Protein – Cat# MBS141498

Interleukin-1 Receptor Antagonist (mIL1RA) Mouse Active Protein

Name: mIL1RA Active Protein; Interleukin-1 Receptor Antagonist; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS141498
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS141498

Introduction: Interleukin-1 ra is a member of the interleukin 1 cytokine family. IL1RAinhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses.… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Interleukin-1 Receptor Antagonist (mIL1RA), Active Protein

Full Product Name

Recombinant Mouse Interleukin-1 Receptor Antagonist, His Tag, Active

Product Gene Name

mIL1RA active protein

Product Synonym Names

IRAP; IL1F3; IL1RA; IL-1ra3; ICIL-1RA; IL1RN; IL1 inhibitor; IL-1ra; F630041P17Rik; IL1RA Mouse, His Active; Interleukin-1 Receptor Antagonist Mouse Recombinant, Active His Tag

Sequence

Amino acid: MGSSHHHHHH SSGLVPRGSH MGSHMRPSGK RPCKMQAFRI WDTNQKTFYL RNNQLIAGYL QGPNIKLEEK IDMVPIDLHS VFLGIHGGKL CLSCAKSGDD IKLQLEEVNI TDLSKNKEED KRFTFIRSEK GPTTSFESAA CPGWFLCTTL EADRPVSLTN TPEEPLIVTK FYFQEDQ

Host

E Coli

Form/Format

Sterile filtered colorless solution.
The IL1RA solution (1 mg/ml) contains 10% Glycerol, 20mM Tris-HCl buffer (pH 8.0) and 0.1M NaCl

Purity/Purification

>95.0% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks.
Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.

3D Structure

ModBase 3D Structure for P25085

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Measured by the ability to inhibit proliferation using D10.G4.1 mouse helper T cells. ED50 for this effect is <= 60ng/ml with Mouse IL-1 alpha.

Product Categories/Family for mIL1RA active protein

CYTOKINES AND GROWTH FACTORS

Other Notes

Small volumes of mIL1RA active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for mIL1RA purchase

MBS141498 is an active protein targeting mIL1RA. Also known as Recombinant Mouse Interleukin-1 Receptor Antagonist, His Tag, Active. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for mIL1RA. It may not necessarily be applicable to this product.

NCBI GI #

89257344

NCBI GeneID

16181

NCBI Accession #

NP_001034790.1

UniProt Primary Accession #

P25085

UniProt Related Accession #

P25085

GenBank Nucleotide #

NP_001034790.1

NCBI Official Full Name

interleukin-1 receptor antagonist protein isoform 2

NCBI Official Synonym Full Names

interleukin 1 receptor antagonist

NCBI Official Symbol

Il1rn

NCBI Official Synonym Symbols

IL-1ra; F630041P17Rik

UniProt Protein Name

Interleukin-1 receptor antagonist protein

UniProt Synonym Protein Names

IL1 inhibitor

Protein Family

Interleukin-1 receptor antagonist protein

UniProt Gene Name

Il1rn

UniProt Synonym Gene Names

Il-1ra; IL-1RN; IL-1ra; IRAP

UniProt Entry Name

IL1RA_MOUSE

NCBI Protein Information

interleukin-1 receptor antagonist protein

UniProt Comments for mIL1RA

IL1RN: Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. The intracellular form of IL1RN is predominantly expressed in epithelial cells. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Secreted; Secreted, signal peptide; Vesicle

Cellular Component: extracellular space; cell; cytoplasm; extracellular region; vesicle

Molecular Function: interleukin-1 Type I receptor antagonist activity; interleukin-1 receptor binding; interleukin-1 Type II receptor antagonist activity; interleukin-1, Type II receptor binding; cytokine activity; interleukin-1, Type I receptor binding; interleukin-1 receptor antagonist activity

Biological Process: positive regulation of JNK activity; negative regulation of glutamate secretion; negative regulation of heterotypic cell-cell adhesion; cytokine and chemokine mediated signaling pathway; response to glucocorticoid stimulus; fever; sensory perception of pain; memory; insulin secretion; acute-phase response; negative regulation of cytokine and chemokine mediated signaling pathway; lipid metabolic process; negative regulation of membrane potential; negative regulation of cell migration; negative regulation of apoptosis

Research Articles on mIL1RA

1. Combinatorial Prg4 and Il-1ra Gene Therapy Protects Against Hyperalgesia and Cartilage Degeneration in Post-Traumatic Osteoarthritis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with mIL1RA active protein

Products by Pathway	Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
IL-1 Signaling Pathway antibodies	IL-1 Signaling Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Interleukin-1 Signaling Pathway antibodies	Interleukin-1 Signaling Pathway Diagram
Signaling By Interleukins Pathway antibodies	Signaling By Interleukins Pathway Diagram

Diseases associated with mIL1RA active protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>778 publications with mIL1RA and Necrosis
Inflammation Antibodies	>697 publications with mIL1RA and Inflammation
Arthritis, Rheumatoid Antibodies	>302 publications with mIL1RA and Arthritis, Rheumatoid
Cardiovascular Diseases Antibodies	>190 publications with mIL1RA and Cardiovascular Diseases
Disease Models, Animal Antibodies	>165 publications with mIL1RA and Disease Models, Animal
Skin Diseases Antibodies	>126 publications with mIL1RA and Skin Diseases
Lung Diseases Antibodies	>111 publications with mIL1RA and Lung Diseases
Pain Antibodies	>82 publications with mIL1RA and Pain
Kidney Diseases Antibodies	>80 publications with mIL1RA and Kidney Diseases
Heart Diseases Antibodies	>76 publications with mIL1RA and Heart Diseases

Organs/Tissues associated with mIL1RA active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1072 publications with mIL1RA and Blood
Skin Antibodies	>127 publications with mIL1RA and Skin
Bone Marrow Antibodies	>67 publications with mIL1RA and Bone Marrow
Stomach Antibodies	>51 publications with mIL1RA and Stomach
Connective Tissue Antibodies	>50 publications with mIL1RA and Connective Tissue
Spleen Antibodies	>43 publications with mIL1RA and Spleen
Intestine Antibodies	>40 publications with mIL1RA and Intestine
Eye Antibodies	>38 publications with mIL1RA and Eye
Vagina Antibodies	>11 publications with mIL1RA and Vagina
Thymus Antibodies	>7 publications with mIL1RA and Thymus