Canine k9IL1A Active Protein – Cat# MBS141524

Interleukin-1 Alpha (k9IL1A) Canine Active Protein

Name: k9IL1A Active Protein; Interleukin-1 Alpha; Canine; MyBioSource
Brand: MyBioSource
SKU: MBS141524
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS141524

The cytokine IL-1 alpha or hematopoietin 1 is a member to the interleukin 1 family, encoded by the IL1A gene in humans. Essentially Il-1 is in charge of inflammation and the rising of fever and sepsis. In order to disturb the mentioned processes and treatment… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Interleukin-1 alpha (k9IL1A), Active Protein

Full Product Name

Recombinant Canine Interleukin-1 alpha

Product Gene Name

k9IL1A active protein

Product Synonym Names

k9IL1A; IL1A Canine; Interleukin-1 alpha Canine Recombinant; interleukin 1 alpha; IL1A; interleukin-1 alpha precursor;BAF; Hematopoietin-1; IL1 alpha; IL1F1hematopoietin-1; LAF; LEM; preinterleukin 1 alpha; pro-interleukin-1-alpha

Sequence

ADPSVAYNFH NNEKYNYIRI IKSQFILNDN LNQSIVRQTG GNYLMTAALQ NLDDAVKFDM GAYTSEDSKL PVTLRISKTR LFVSAQNEDE PVLLKEMPET PKTIRDETNL LFFWERHGSK HYFKSVAQPK LFIATQERKL VHMARGQPSI TDFRLLETQP HHHHHH

Host

Sf9, Baculovirus cells

Form/Format

Sterile filtered colorless solution.
IL1A protein solution (0.25mg/ml) containing Phosphate-Buffered Saline (pH7.4) and 10% glycerol.

Purity/Purification

Greater than 90.0% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks.
Store, frozen at -20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Molecular Weight

30,522 Da

3D Structure

ModBase 3D Structure for O46612

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Measured in a cell proliferation assay using D10.G4.1 mouse helper T cell. The ED50 range <= 2ng/ml.

Product Categories/Family for k9IL1A active protein

CYTOKINES AND GROWTH FACTORS

Other Notes

Small volumes of k9IL1A active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for k9IL1A purchase

MBS141524 is an active protein targeting k9IL1A. Also known as Recombinant Canine Interleukin-1 alpha. Host: Sf9, Baculovirus cells.

Additional Details

NCBI/Uniprot data below describe general gene information for k9IL1A. It may not necessarily be applicable to this product.

NCBI GI #

148236731

NCBI GeneID

403782

NCBI Accession #

NP_001003157.2

UniProt Primary Accession #

O46612

UniProt Secondary Accession #

Q006K7

UniProt Related Accession #

O46612

GenBank Nucleotide #

NM_001003157.2

NCBI Official Full Name

interleukin-1 alpha

NCBI Official Synonym Full Names

interleukin 1 alpha

NCBI Official Symbol

IL1A

UniProt Protein Name

Interleukin-1 alpha

Protein Family

Interleukin

UniProt Gene Name

IL1A

UniProt Synonym Gene Names

IL-1 alpha

NCBI Protein Information

interleukin-1 alpha

UniProt Comments for k9IL1A

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells ().

Research Articles on k9IL1A

1. in silico complete mRNA structures of the IL-1alpha and IL-1beta mRNAs in dogs.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with k9IL1A active protein

Reference Product	PubMed Publications
IL1B active protein	>250 publications with k9IL1A and IL1B
IL1R1 active protein	>16 publications with k9IL1A and IL1R1
MYD88 active protein	>5 publications with k9IL1A and MYD88
IL1R2 active protein	>3 publications with k9IL1A and IL1R2
TRAF6 active protein	>2 publications with k9IL1A and TRAF6
IRAK1 active protein	>1 publications with k9IL1A and IRAK1
IRAK3 active protein	>1 publications with k9IL1A and IRAK3
IL1RAP active protein	>1 publications with k9IL1A and IL1RAP

Pathways associated with k9IL1A active protein

Products by Pathway	Pathway Diagram
AGE-RAGE Signaling Pathway In Diabetic Complications antibodies	AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
AGE-RAGE Signaling Pathway In Diabetic Complications antibodies	AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokines And Inflammatory Response Pathway antibodies	Cytokines And Inflammatory Response Pathway Diagram
FAS Pathway And Stress Induction Of HSP Regulation antibodies	FAS Pathway And Stress Induction Of HSP Regulation Diagram
Graft-versus-host Disease Pathway antibodies	Graft-versus-host Disease Pathway Diagram
Graft-versus-host Disease Pathway antibodies	Graft-versus-host Disease Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram

Diseases associated with k9IL1A active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>136 publications with k9IL1A and Inflammation
Necrosis Antibodies	>80 publications with k9IL1A and Necrosis
Skin Diseases Antibodies	>39 publications with k9IL1A and Skin Diseases
Pain Antibodies	>13 publications with k9IL1A and Pain
Heart Diseases Antibodies	>13 publications with k9IL1A and Heart Diseases
Liver Diseases Antibodies	>11 publications with k9IL1A and Liver Diseases
Fibrosis Antibodies	>11 publications with k9IL1A and Fibrosis
Kidney Diseases Antibodies	>10 publications with k9IL1A and Kidney Diseases
Myocardial Ischemia Antibodies	>9 publications with k9IL1A and Myocardial Ischemia
Hypertension Antibodies	>7 publications with k9IL1A and Hypertension