Human IL10RA Active Protein – Cat# MBS141532

Interleukin 10 Receptor Alpha (IL10RA) Human Active Protein

Name: IL10RA Active Protein; Interleukin 10 Receptor Alpha; Human; MyBioSource
Brand: MyBioSource
SKU: MBS141532
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS141532

Interleukin 10 receptor, alpha subunit or CDW210A, is a part of the IL-10 receptor. This protein is encoded by the IL10RA gene in humans. IL10RA is a receptor for IL-10 (interleukin 10), it is part of the interferon receptors family. This protein is… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Interleukin 10 Receptor Alpha (IL10RA), Active Protein

Full Product Name

Recombinant Human Interleukin 10 Receptor Alpha, BioActive

Product Gene Name

IL10RA active protein

Product Synonym Names

IL10RA Active; IL10RA Human Active; Interleukin 10 Receptor Alpha Human Recombinant; BioActive; Interleukin 10 Receptor; Alpha; IL10R; Interleukin-10 Receptor Subunit 1; IL-10 Receptor Subunit Alpha; IL-10R Subunit Alpha; IL-10R Subunit 1; CDW210A; IL-10R1; IL-10RA; Interleukin-10 Receptor Subunit Alpha; Interleukin-10 Receptor Alpha Chain; CD210 Antigen; HIL-10R; CD210a; CD210; IBD28; IL10RA

Sequence

HGTELPSPPS VWFEAEFFHH ILHWTPIPNQ SESTCYEVAL LRYGIESWNS ISNCSQTLSY DLTAVTLDLY HSNGYRARVR AVDGSRHSNW TVTNTRFSVD EVTLTVGSVN LEIHNGFILG KIQLPRPKMA PANDTYESIF SHFREYEIAI RKVPGNFTFT HKKVKHENFS CVQVKPSVAS RSNKGMWSKE ECISLTRQYF TVTNHHHHHH

Host

Sf9, Baculovirus cells

Form/Format

Sterile filtered colorless solution
The IL10RA solution (0.2mg/ml) contains 20% Glycerol and Phosphate-Buffered Saline (pH7.4).

Purity/Purification

Greater than 90.0% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks.
Store, frozen at -20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.

Molecular Weight

63,003 Da

Chromosome Location

Chromosome: 11; NC_000011.9 (117857106..117872198). Location: 11q23

OMIM

146933

3D Structure

ModBase 3D Structure for Q13651

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Determined by its ability to inhibit proliferation using MC/9 mouse mast cells. ED50 for this effect is <= 300ng/ml with Human IL-10.

Product Categories/Family for IL10RA active protein

CYTOKINES AND GROWTH FACTORS

Other Notes

Small volumes of IL10RA active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL10RA purchase

MBS141532 is an active protein targeting IL10RA. Also known as Recombinant Human Interleukin 10 Receptor Alpha, BioActive. Host: Sf9, Baculovirus cells.

Additional Details

NCBI/Uniprot data below describe general gene information for IL10RA. It may not necessarily be applicable to this product.

NCBI GI #

222136575

NCBI GeneID

3587

NCBI Accession #

NP_001549.2

UniProt Primary Accession #

Q13651

UniProt Secondary Accession #

A8K6I0; B0YJ27

UniProt Related Accession #

Q13651

GenBank Nucleotide #

NM_001558.3

NCBI Official Full Name

interleukin-10 receptor subunit alpha

NCBI Official Synonym Full Names

interleukin 10 receptor, alpha

NCBI Official Symbol

IL10RA

NCBI Official Synonym Symbols

CD210; IL10R; CD210a; CDW210A; HIL-10R; IL-10R1

UniProt Protein Name

Interleukin-10 receptor subunit alpha

UniProt Synonym Protein Names

CDw210a; Interleukin-10 receptor subunit 1

Protein Family

Interleukin-10 receptor

UniProt Gene Name

IL10RA

UniProt Synonym Gene Names

IL10R; IL-10 receptor subunit alpha; IL-10R subunit alpha; IL-10RA; IL-10R subunit 1; IL-10R1

UniProt Entry Name

I10R1_HUMAN

NCBI Protein Information

interleukin-10 receptor subunit alpha; IL-10RA; IL-10R subunit 1; IL-10R subunit alpha; IL-10 receptor subunit alpha; interleukin-10 receptor subunit 1; interleukin-10 receptor alpha chain

NCBI Summary for IL10RA

The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]

UniProt Comments for IL10RA

IL10RA: a receptor for interleukin 10 structurally related to interferon receptors. Mediates the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: plasma membrane; integral to membrane

Molecular Function: signal transducer activity; protein binding; interleukin-10 binding; interleukin-10 receptor activity; receptor activity

Biological Process: cytokine and chemokine mediated signaling pathway; response to lipopolysaccharide

Disease: Inflammatory Bowel Disease 28, Autosomal Recessive

Research Articles on IL10RA

1. The dynamic genome-wide transcriptional responses were nearly identical at early time points following stimulation (when STAT3 is active in response to both IL-6 and IL-10) but divergent at later times (when STAT3 is active only in response to IL-10).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL10RA active protein

Reference Product	PubMed Publications
IL10 active protein	>19 publications with IL10RA and IL10
IL10RB active protein	>10 publications with IL10RA and IL10RB
JAK1 active protein	>1 publications with IL10RA and JAK1

Pathways associated with IL10RA active protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Epstein-Barr Virus Infection Pathway antibodies	Epstein-Barr Virus Infection Pathway Diagram
Epstein-Barr Virus Infection Pathway antibodies	Epstein-Barr Virus Infection Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Toxoplasmosis Pathway antibodies	Toxoplasmosis Pathway Diagram
Toxoplasmosis Pathway antibodies	Toxoplasmosis Pathway Diagram
Tuberculosis Pathway antibodies	Tuberculosis Pathway Diagram
Tuberculosis Pathway antibodies	Tuberculosis Pathway Diagram

Diseases associated with IL10RA active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>10 publications with IL10RA and Inflammation
Cardiovascular Diseases Antibodies	>4 publications with IL10RA and Cardiovascular Diseases
Neoplasms Antibodies	>4 publications with IL10RA and Neoplasms
Necrosis Antibodies	>4 publications with IL10RA and Necrosis
Brain Diseases Antibodies	>2 publications with IL10RA and Brain Diseases
Liver Diseases Antibodies	>2 publications with IL10RA and Liver Diseases
Skin Diseases Antibodies	>2 publications with IL10RA and Skin Diseases
Disease Models, Animal Antibodies	>1 publications with IL10RA and Disease Models, Animal
Lung Diseases Antibodies	>1 publications with IL10RA and Lung Diseases
Kidney Diseases Antibodies	>1 publications with IL10RA and Kidney Diseases

Organs/Tissues associated with IL10RA active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>15 publications with IL10RA and Blood
Brain Antibodies	>3 publications with IL10RA and Brain
Bone Antibodies	>3 publications with IL10RA and Bone
Skin Antibodies	>2 publications with IL10RA and Skin
Vascular Antibodies	>2 publications with IL10RA and Vascular
Tonsil Antibodies	>1 publications with IL10RA and Tonsil
Pharynx Antibodies	>1 publications with IL10RA and Pharynx
Lung Antibodies	>1 publications with IL10RA and Lung
Spleen Antibodies	>1 publications with IL10RA and Spleen
Thymus Antibodies	>1 publications with IL10RA and Thymus