Mouse mNTRK3 Recombinant Protein – Cat# MBS141537

Neurotrophic Receptor Tyrosine Kinase 3 (mNTRK3) Mouse Recombinant Protein

Name: mNTRK3 Recombinant Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS141537
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS141537

Neurotrophic Receptor Tyrosine Kinase 3 (NTRK3) belongs to the receptor tyrosine kinases family and is a high affinity catalytic receptor of neurotrophin NT-3. NTRK3 mediates multiple effects of this neurotrophic factor, which includes neuronal… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Neurotrophic Receptor Tyrosine Kinase 3 (mNTRK3), Recombinant Protein

Full Product Name

Recombinant Mouse Neurotrophic Receptor Tyrosine Kinase 3

Product Gene Name

mNTRK3 recombinant protein

Product Synonym Names

mNTRK3; NTRK3 Mouse; Neurotrophic Receptor Tyrosine Kinase 3 Mouse Recombinant; NT-3 growth factor receptor; GP145-TrkC; Trk-C; Neurotrophic tyrosine kinase receptor type 3; TrkC tyrosine kinase; Ntrk3; TrkC; AW125844; Ntrk3_tv3

Sequence

CPANCVCSKT EINCRRPDDG NLFPLLEGQD SGNSNGNASI NITDISRNIT SIHIENWRGL HTLNAVDMEL YTGLQKLTIK NSGLRNIQPR AFAKNPHLRY INLSSNRLTT LSWQLFQTLS LRELRLEQNF FNCSCDIRWM QLWQEQGEAR LDSQSLYCIS ADGSQLPLFR MNISQCDLPE ISVSHVNLTV REGDNAVITC NGSGSPLPDV DWIVTGLQSI NTHQTNLNWT NVHAINLTLV NVTSEDNGFT LTCIAENVVG MSNASVALTV YYPPRVVSLV EPEVRLEHCI EFVVRGNPTP TLHWLYNGQP LRESKIIHMD YYQEGEVSEG CLLFNKPTHY NNGNYTLIAK NALGTANQTI NGHFLKEPFP ESTDFFDFES DASPTPPITV THKPEEDTHH HHHH

Host

Sf9, Baculovirus cells

Form/Format

Sterile filtered colorless solution.
NTRK3 protein (0.25mg/ml) contains 10% glycerol and Phosphate-Buffered Saline (pH7.4).

Purity/Purification

Greater than 90.0% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks.
Store, frozen at -20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Molecular Weight

92,760 Da

Chromosome Location

Chromosome: 7; NC_000073.6 (78179986..78577859, complement). Location: 7 D3; 7 44.01 cM

3D Structure

ModBase 3D Structure for Q6VNS1

Product Categories/Family for mNTRK3 recombinant protein

CYTOKINES AND GROWTH FACTORS

Other Notes

Small volumes of mNTRK3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for mNTRK3 purchase

MBS141537 is a recombinant protein targeting mNTRK3. Also known as Recombinant Mouse Neurotrophic Receptor Tyrosine Kinase 3. Host: Sf9, Baculovirus cells.

Additional Details

NCBI/Uniprot data below describe general gene information for mNTRK3. It may not necessarily be applicable to this product.

NCBI GI #

33413412

NCBI GeneID

18213

NCBI Accession #

NP_032772.3

UniProt Primary Accession #

Q6VNS1

UniProt Secondary Accession #

Q9Z2P9; Q9Z2Q0; A4QPD0

UniProt Related Accession #

Q6VNS1

GenBank Nucleotide #

NM_008746.5

NCBI Official Full Name

NT-3 growth factor receptor isoform a

NCBI Official Synonym Full Names

neurotrophic tyrosine kinase, receptor, type 3

NCBI Official Symbol

Ntrk3

NCBI Official Synonym Symbols

TrkC; AW125844; Ntrk3_tv3

UniProt Protein Name

NT-3 growth factor receptor

UniProt Synonym Protein Names

GP145-TrkC; Trk-C; Neurotrophic tyrosine kinase receptor type 3; TrkC tyrosine kinase

UniProt Gene Name

Ntrk3

UniProt Synonym Gene Names

TrkC; Trk-C

UniProt Entry Name

NTRK3_MOUSE

NCBI Protein Information

NT-3 growth factor receptor; trk-C; GP145-TrkC; neurotrophin-3; trkC tyrosine kinase

UniProt Comments for mNTRK3

Function: Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1

By similarity.

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subunit structure: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and KIDINS220

By similarity.

Subcellular location: Membrane; Single-pass type I membrane protein

By similarity.

Tissue specificity: Isoform 2 expression is restricted to specific areas in adult brain. Isoform 3 transcripts are readily detected early during embryogenesis and are expressed predominantly in adult brain and gonads. Ref.2

Post-translational modification: Ligand-mediated auto-phosphorylation

By similarity.

Sequence similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.Contains 2 Ig-like C2-type (immunoglobulin-like) domains.Contains 2 LRR (leucine-rich) repeats.Contains 1 LRRCT domain.Contains 1 protein kinase domain.

Research Articles on mNTRK3

1. TrkC expression in E13.5 VCG neurons requires NeuroD and that TrkC expression may be necessary for the normal migration and innervations of those neurons.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with mNTRK3 recombinant protein

Products by Pathway	Pathway Diagram
Neurotrophin Signaling Pathway antibodies	Neurotrophin Signaling Pathway Diagram
Neurotrophin Signaling Pathway antibodies	Neurotrophin Signaling Pathway Diagram
PodNet: Protein-protein Interactions In The Podocyte Pathway antibodies	PodNet: Protein-protein Interactions In The Podocyte Pathway Diagram
XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway antibodies	XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway Diagram

Diseases associated with mNTRK3 recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>251 publications with mNTRK3 and Neoplasms
Nervous System Diseases Antibodies	>148 publications with mNTRK3 and Nervous System Diseases
Death Antibodies	>136 publications with mNTRK3 and Death
Central Nervous System Diseases Antibodies	>109 publications with mNTRK3 and Central Nervous System Diseases
Brain Diseases Antibodies	>103 publications with mNTRK3 and Brain Diseases
Disease Models, Animal Antibodies	>45 publications with mNTRK3 and Disease Models, Animal
Nerve Degeneration Antibodies	>37 publications with mNTRK3 and Nerve Degeneration
Breast Neoplasms Antibodies	>34 publications with mNTRK3 and Breast Neoplasms
Cardiovascular Diseases Antibodies	>23 publications with mNTRK3 and Cardiovascular Diseases
Kidney Diseases Antibodies	>23 publications with mNTRK3 and Kidney Diseases

Organs/Tissues associated with mNTRK3 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>673 publications with mNTRK3 and Brain